Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$135K - $160K *

Lead the development of AI-driven systems for onboarding and compliance, enhancing customer journeys for major financial institutions. Collaborate with cross-functional teams to optimize processes and...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $85K *

Drive your career forward by managing operations that boost sales, profitability, and customer satisfaction. Lead a dynamic team, oversee financial management, and develop strategic plans to enhance m...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$106K - $284K *

Elevate your career by leading a dynamic engineering team to build scalable, cloud-native solutions within the Salesforce ecosystem, driving innovation across key business areas like Marketing, Sales...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Lead the charge in optimizing our rendering system, enhancing performance and user experience across cutting-edge video technologies. Collaborate with a dynamic team to push the boundaries of audio an...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$116K - $171K *

Join a team that's dedicated to delivering exceptional technical support to strategic customers. Leverage your expertise to resolve complex issues, enhance customer experiences, and drive improvements...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Transportation

$153K - $226K *

Advance your career by owning and evolving our Workday platform, focusing on payroll and Core HCM. Collaborate with cross-functional teams to design scalable systems that enhance operational efficienc...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Drive impactful data science initiatives by leading a high-performing team, fostering collaboration, and ensuring effective delivery of analytics solutions that create measurable business value and pr...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$145K - $193K *

Architect and enhance robust software solutions for player registration, identity verification, and compliance. Collaborate across teams to optimize performance, scalability, and security while mentor...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$140K - $185K *

Inspire the evolution of a brand by leading innovative design for campaigns and web experiences. Collaborate across teams to develop scalable brand systems, mentor creatives, and direct impactful stor...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Lead a team of licensed engineers and architects, overseeing project management, design evaluations, and personnel development to ensure compliance and successful execution of capital improvement init...

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$87K - $110K *

Unlock your potential as you lead innovative research projects, collaborate with diverse teams, and drive data-driven solutions that enhance opportunities and improve lives across various policy areas...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Join a dynamic team to engage members through warm sales calls and in-branch consultations, identifying their financial needs and promoting life insurance products while delivering exceptional custome...

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$190K - $220K *

Champion robust data integration while collaborating with cross-functional teams to design and optimize data pipelines, directly influencing our rapidly scaling marketing intelligence platform's succe...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Lead strategic sales initiatives across the Mid-West Territory, driving business growth through effective account management and relationship building. Collaborate cross-functionally to achieve sales...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$95K - $115K *

Join a team that's passionate about family medicine, delivering compassionate care through in-depth patient assessments and individualized treatment plans while collaborating effectively in a dynamic...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform patient access and capacity management by leading strategic initiatives, optimizing workflows, and enhancing provider scheduling across multiple service lines to improve operational efficien...

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$159K - $230K *

Join a team that's redefining AI and Infrastructure by leading complex, multi-disciplinary projects. Collaborate with diverse stakeholders to drive innovation and ensure seamless execution across glob...

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$109K - $150K *

Empower employee relations by providing expert guidance, conducting investigations, and developing policies. Collaborate with HR and legal teams to enhance workplace culture and ensure compliance with...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Advance your career with a dynamic family medicine practice focusing on patient care, independent management, and comprehensive health assessments in a supportive environment with growth potential...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead technical discovery and deliver tailored demos to showcase solutions, partnering with sales teams to drive client success and enhance the buying journey for educational institutions...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$97K - $120K *

Engage in dynamic creative execution across multiple platforms, transforming concepts into compelling campaigns. Collaborate with teams to deliver impactful messaging while leveraging insights for con...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$117K - $195K *

Elevate your career by leading custom ServiceNow development and integrations. Collaborate with cross-functional teams to enhance ITSM solutions, ensuring seamless interoperability and driving technic...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$165K - $195K *

Lead the charge in providing expert legal guidance on complex immigration matters. Manage client relationships, develop strategies, and mentor junior attorneys while ensuring compliance and driving re...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$272K - $408K *

Transform the Product Security landscape by leading a skilled team, driving strategy, and embedding security across engineering processes while fostering innovation and collaboration in a fast-paced e...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$180K *

Drive innovative surgical solutions by leading capital sales in the Central Plains. Engage with clinicians and C-Suite stakeholders to enhance patient care through advanced technologies, ensuring succ...

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.