Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$180K - $225K *

Lead the charge in shaping the future of consumer products for anglers. Drive growth by setting a visionary roadmap, developing a high-performing team, and delivering exceptional user experiences that...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $102K *

Optimize network infrastructure by configuring and supporting Cisco systems, managing performance, and troubleshooting issues to ensure uptime. Collaborate with IT teams to drive security measures and...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$207K - $244K *

Shape the future of payment methods by owning the strategy and roadmap for customer bank accounts, cards, and digital wallets, ensuring seamless integration and optimal performance across platforms...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$72K - $90K *

Join a supportive team to provide telehealth psychotherapy for older adults. Enjoy flexible scheduling, a full caseload, and minimal paperwork while making a meaningful impact in patients' lives. Your...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Elevate your career by leading a dynamic BDR team, driving pipeline generation, and optimizing sales processes. Collaborate with marketing and sales to enhance engagement strategies while fostering ta...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $110K *

Transform construction management through collaboration with franchisees and cross-functional teams. Oversee site feasibility, planning, and execution of new shop projects to ensure timely, cost-effec...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$100K - $130K *

Join our team to conduct ISO/IATF 16949 audits across North America, ensuring compliance and quality. Engage with clients at all management levels, providing detailed reports and guidance while mainta...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$110K - $145K *

Elevate medical communications by developing high-quality, strategic content across therapeutic areas. Collaborate with teams and clients to ensure accuracy and adherence to guidelines while supervisi...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$95K - $125K *

Accelerate progress at the forefront of AI development by building and maintaining reusable context assets. Collaborate with teams to integrate advanced capabilities into applications, ensuring qualit...

3 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$158K - $197K *

Join a team that's dedicated to enhancing client solutions through technical expertise. Lead projects, collaborate with teams, and ensure best practices in business process management while guiding te...

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$215K - $250K *

Build your career with a pioneering role to shape grantmaking, partner programs, and organizational independence. Lead initiatives, engage stakeholders, and measure success while establishing a founda...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $200K *

Transform your career by leading key client relationships, understanding business goals, and driving innovative manufacturing solutions to market. Leverage your expertise to boost sales and collaborat...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$63K - $98K *

Lead the charge in ensuring seamless onboarding for new customers, coordinating efforts across teams to deliver a professional transition from sales to support, while fostering strong relationships an...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $125K *

Empower growth by driving strategic account management and sales initiatives. Collaborate with diverse teams to deliver innovative manufacturing solutions, ensuring client success and exceeding revenu...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$164K - $241K *

Lead a global TPRM program, enhancing vendor security risk management through AI-driven workflows and assessments. Manage a team, ensure compliance, and drive risk decisions while collaborating with c...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$86K - $138K *

Optimize financial analysis and reporting by conducting in-depth research, preparing forecasts, and collaborating across departments to enhance business outcomes and drive strategic decision-making...

RemoteRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $110K *

Join us to drive cross-functional GTM initiatives, enhance operational efficiency, and support executive decision-making. You'll collaborate with teams to align strategies and improve processes, ensur...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$125K - $137K *

Optimize thermal systems engineering by leading design and performance of skidded equipment for diverse markets. Collaborate across teams to enhance manufacturability and ensure reliable, documented e...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$128K - $191K *

Join a team that's driving growth in the CBRNe Safety & Security sector. You'll identify new business opportunities, develop strategies, and manage the sales cycle while collaborating with cross-funct...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Elevate your career by leading strategic initiatives that drive provider growth. Collaborate with C-suite leaders to design scalable operations and align cross-functional teams, while mentoring a dedi...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Healthcare

$100K *

Champion exceptional veterinary care by joining a dynamic team focused on exotic and avian medicine. Leverage your skills in a supportive environment that fosters growth, collaboration, and client rel...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $123K *

Transform your career by joining a dynamic team focused on innovative full stack development, integrating AI capabilities, and delivering robust solutions for diverse business needs. Collaborate with...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Champion innovative research in clinical assessments, leading product development and strategy across multiple domains. Collaborate with cross-functional teams to translate scientific evidence into im...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$280K - $330K *

Empower a dynamic engineering team by leading technical architecture, enhancing system reliability, and driving scalable solutions that support rapid growth in a fast-paced fintech environment. Foster...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $180K *

Drive growth and satisfaction by managing client relationships in Life Sciences. Oversee the sales process, collaborate with experts, and leverage insights to uncover new opportunities while ensuring...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.