Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$85K - $90K *

Unlock potential by leading a dynamic Customer Success team to enhance client satisfaction, drive product adoption, and identify upselling opportunities, ensuring customers achieve their business goal...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K *

Empower your sales career by driving growth in the SaaS/Security sector. Build relationships with key decision-makers, exceed quotas, and collaborate across teams to deliver exceptional value and solu...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $140K *

Transform the future of software development by architecting and enhancing back-end solutions across diverse applications, mentoring engineers, and driving Agile processes to deliver high-quality soft...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$75K - $95K *

Join a team that's dedicated to delivering impactful user events across North America and Europe. You'll manage logistics, coordinate teams, and ensure engaging experiences that drive product adoption...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$200K - $232K *

Lead the charge in shaping innovative educational products for universities, enhancing faculty engagement and institutional adoption through AI-driven solutions and comprehensive support, while drivin...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$108K - $155K *

Elevate your career by leading complex public sector deployments, ensuring seamless execution of Zero Trust solutions while collaborating with cross-functional teams to achieve impactful business outc...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Transform core GRC platform capabilities into intelligent, agentic experiences. Own the product strategy, engage with stakeholders, and redefine user workflows while enhancing automation and flexibili...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $100K *

Advance your career by providing telehealth psychotherapy to older adults. Enjoy flexible scheduling, a supportive team, and a full caseload tailored to your availability. Focus on meaningful work wit...

Missouri, USRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Explore a pivotal role in delivering high-value cost management services for a large-scale data center program, ensuring accuracy and consistency across multiple phases while leading client interactio...

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$9K - $185K *

Lead the optimization of large-scale SQL Server databases, enhancing performance and efficiency. Drive data mining capabilities by resolving bottlenecks and implementing innovative solutions that dire...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Transform patient care by leading the Cardiovascular Telemetry department, ensuring high-quality nursing practices, resource management, and exceptional clinical outcomes while fostering a supportive...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Help us shape the future of partner marketing by crafting compelling narratives that drive adoption and engagement for our Buyer Intent product line, collaborating with cross-functional teams to deliv...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Unlock new business opportunities by driving sales growth in emerging healthcare markets. This role focuses on building relationships with non-national health plans and technology partners, achieving...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $140K *

Join a dynamic team as a Tenable Administrator, managing endpoint security platforms. Leverage your expertise in Linux and vulnerability management to enhance security protocols and support our Intell...

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$198K - $267K *

Unlock potential by leading the development of complex software systems for cutting-edge unmanned aircraft. Collaborate with a team of engineers to create real-time embedded solutions that enhance ope...

Reposted 3 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$106K - $177K *

Shape customer success by managing enterprise accounts, driving satisfaction and retention through strategic guidance, proactive support, and relationship building. Collaborate with sales teams to max...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Transform customer success at a strategic level by leading a diverse team of CSMs, driving initiatives to enhance satisfaction, retention, and growth while collaborating across departments to align wi...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$61K - $102K *

Transform customer relationships by managing a high-volume portfolio, driving renewals, upsell, and cross-sell opportunities while ensuring exceptional engagement and retention across North America...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$79K - $98K *

Empower customer success by fostering relationships and driving value through strategic engagement and support. Collaborate cross-functionally to enhance customer satisfaction and retention while iden...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$291K - $312K *

Shape the future of primary care by delivering compassionate, evidence-based treatment through innovative digital platforms, collaborating with a diverse team to enhance patient outcomes and foster in...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$181K - $232K *

Lead product innovation and streamline customer migration to flagship platform, leveraging advanced technical skills to design scalable, secure applications and enhance user experiences through effect...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$100K - $120K *

Shape the future of startups by driving high-impact initiatives across multiple portfolio companies. Engage directly with founders to tackle critical challenges, scale operations, and explore new busi...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$172K - $203K *

Tackle complex reliability challenges in consumer hardware by building data-driven models and systems. Collaborate cross-functionally to enhance product quality and performance, leveraging advanced an...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $130K *

Empower teams by translating complex data into actionable insights, guiding strategic financial modeling, and enhancing decision-making processes for portfolio companies through collaborative relation...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$119K - $186K *

Lead transformative process improvements by leveraging customer insights to enhance operational excellence across Health Systems & Government Services, ensuring scalable, customer-centered execution a...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.