Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$150K - $180K *

Drive transformational growth by managing critical customer relationships and partnerships. Leverage AI insights to shape enterprise strategies, influence executive decisions, and mentor sales profess...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$85K - $95K *

Develop and deliver engaging training programs to enhance user adoption and operational excellence. Collaborate with diverse teams to create effective learning solutions, ensuring content aligns with...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$185K - $275K *

Transform the future of IT programs by leading a dynamic team in planning, budgeting, and compliance. Drive performance and innovation while ensuring alignment with organizational goals in a fully rem...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $120K *

Lead the charge in ensuring safety compliance on large-scale construction projects. Oversee safety personnel, promote a safety culture, and manage documentation while collaborating with teams to mitig...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$95K - $115K *

Lead the charge in managing engineering and manufacturing projects, collaborating across teams to ensure timely execution, budget adherence, and high-quality outcomes that drive business growth and in...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$116K - $164K *

Engineer comprehensive land development projects for EV and AV charging stations. Oversee design, permitting, and construction phases while managing budgets and client communications. Collaborate with...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K *

Advance your career by auditing outpatient and specialty claims, ensuring coding accuracy and compliance. Leverage your clinical and coding expertise to enhance audit processes and contribute to quali...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$180K - $220K *

Lead the charge in transforming healthcare revenue cycles by optimizing financial operations, ensuring compliance, and enhancing patient experiences. Drive strategic initiatives and foster collaborati...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$175K - $210K *

Transform the accounting landscape by leading a multi-disciplinary team, enhancing operational efficiency, and driving innovation through AI and automation while ensuring compliance and integrity in f...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Drive impactful decision-making and support for EHRM initiatives, enhancing operational efficiency and stakeholder engagement through strategic analysis, project management, and effective communicatio...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Shape the future of healthcare IT by managing complex integration programs, driving Lean-Agile adoption, and ensuring successful delivery of enterprise reporting and analytics initiatives across multi...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Healthcare

$162K - $195K *

Join a team that's dedicated to launching innovative cardiac therapies. Drive sales performance, build strategic relationships, and serve as a key resource in your territory, focusing on patient needs...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $195K *

Drive sales performance by launching a novel cardiac myosin inhibitor, building strategic relationships with healthcare providers, and coordinating a local integrated field team to meet patient needs...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $123K *

Join a team that's dedicated to enhancing Payment Integrity Audit programs by collaborating with stakeholders, managing inventory, and driving process improvements in a fast-paced environment focused...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$85K - $110K *

Elevate quality assurance in clinical DRG audits by mentoring auditors, ensuring accuracy, and recommending process improvements. Collaborate with peers to enhance performance and uphold compliance st...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$93K - $163K *

Drive effective marketing strategies for cybersecurity offerings, collaborating with cross-functional teams to enhance product management and deliver impactful go-to-market initiatives, while ensuring...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead collaborative HR strategies to foster an inclusive workplace, drive talent management, and align organizational effectiveness with business goals across the campus...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Shape the future of logistics by managing operations, ensuring customer satisfaction, and leading teams. Drive profitability through effective P&L analysis while fostering a culture of safety and comp...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Transportation

$85K - $95K *

Transform HR operations by leading Global HR Shared Services for the NAM region, driving efficiency, process improvement, and digital transformation while ensuring alignment with global HR strategies...

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$73K - $101K *

Unlock potential by leading installation, maintenance, and repair of low voltage power distribution systems. Collaborate with teams to ensure safety and efficiency while delivering exceptional service...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$115K - $131K *

Join our Urgent Care team to deliver exceptional healthcare experiences in a fast-paced environment. Utilize your diagnostic skills and clinical expertise to ensure timely, effective care for our comm...

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Elevate your career by driving sales in the employer benefits space. Shape growth, manage relationships, and collaborate across teams to deliver impactful solutions for SMB clients in the Rocky Mounta...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$85K - $90K *

Unlock potential by leading a dynamic Customer Success team to enhance client satisfaction, drive product adoption, and identify upselling opportunities, ensuring customers achieve their business goal...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K *

Empower your sales career by driving growth in the SaaS/Security sector. Build relationships with key decision-makers, exceed quotas, and collaborate across teams to deliver exceptional value and solu...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$112K - $140K *

Transform the future of software development by architecting and enhancing back-end solutions across diverse applications, mentoring engineers, and driving Agile processes to deliver high-quality soft...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.