Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$125K - $150K *

Lead the charge in transforming construction management through digital delivery. Collaborate with leadership to set strategic direction, enhance project efficiency, and drive innovation across teams...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$72K - $90K *

Engage in maintaining and repairing top-tier diesel vehicles, ensuring optimal performance and safety. Utilize your expertise in diagnostics and preventive maintenance to support a dynamic team in a f...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$170K - $195K *

Join a team that's dedicated to optimizing global power generation operations. You'll support fleet management, enhance O&M standards, and drive continuous improvement initiatives across a diverse por...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $124K *

Join a team that's dedicated to enhancing Fire Life Safety programs for the FAA. Leverage your expertise in fire protection engineering to support compliance, develop standards, and conduct assessment...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$131K - $237K *

Shape secure, scalable cloud solutions across AWS, Azure, OCI, and GCP. Collaborate with teams to automate deployments, enhance cloud operations, and mentor engineers while supporting mission-critical...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Technical Services

$61K - $122K *

Join a team dedicated to advancing cancer diagnostics by overseeing EHR HL7 interfaces, providing technical support, and leading integration projects. Collaborate with stakeholders to ensure seamless...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$82K - $149K *

Champion a team of call center agents, ensuring high-quality service delivery and compliance. Provide clinical oversight for at-risk cases while driving operational excellence and fostering a supporti...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $120K *

Join a team that enhances patient care by optimizing medication use, ensuring precision in dispensing, and providing drug education. You'll work collaboratively with healthcare professionals while sup...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the charge in operational and scientific excellence within bioanalytical production, driving process improvements and team development to ensure high-quality, compliant study execution in a dynam...

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Champion financial integrity by leading a team in managing accounting policies, ensuring accurate financial reporting, and overseeing complex loan accounting operations for foreign programs within the...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$98K - $115K *

Transform customer support by managing AI operations and content quality. Drive improvements in AI agent performance, oversee Help Center accuracy, and ensure seamless content delivery for enhanced cu...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$135K - $155K *

Advance your career as a hospital sales specialist, driving product adoption and building relationships within healthcare systems. Achieve sales goals while navigating complex environments and collabo...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$140K - $150K *

Unlock potential by leading software implementation projects, applying Agile methodologies, and ensuring client satisfaction through effective communication and collaboration with cross-functional tea...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Lead the charge in engineering excellence by directing a multi-disciplinary team to optimize network performance, ensure high availability, and drive continuous improvement across hybrid-cloud and dat...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Drive impactful digital solutions by championing consumer feedback and leading cross-functional teams to enhance patient experiences and streamline care delivery across all platforms...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Champion strategic marketing initiatives to enhance neurosurgery programs, driving patient engagement and optimizing referral networks through data-driven insights and collaboration with clinical lead...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$87K - $293K *

Transform utilities finance operations by leveraging SAP FI-CA expertise to enhance customer accounting processes, lead project teams, and drive innovative solutions for receivables and cash managemen...

2 days ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Transform enterprise service delivery by leading cross-center operations, enhancing efficiency, and ensuring high-quality IT services across multiple locations. Drive initiatives that improve performa...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $120K *

Unlock potential by providing expert XBRL project support, ensuring compliance and accuracy in financial reporting for diverse clients while collaborating across teams to enhance project delivery and...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$124K - $166K *

Transform operations by leading a team to enhance Field Scheduling and Mobility systems, ensuring seamless support and collaboration across business units while driving process improvements and techni...

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$170K - $200K *

Shape the future of medical affairs by leading a high-performing team of Medical Science Liaisons, driving scientific engagement, and ensuring strategic alignment with healthcare needs while fostering...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Grow your career with us by leading strategic sales initiatives, building relationships with key accounts, and driving business growth in the employer-sponsored health sector. Adapt and thrive in a dy...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Accelerate progress at a leading telecom program by driving automation in engineering activities. Collaborate with cross-functional teams to deliver innovative solutions while managing scope, timeline...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Staffing

$108K - $180K *

Join a team that's dedicated to enhancing non-clinical product performance through data-driven insights. Lead KPI optimization and collaborate with stakeholders to improve user experiences across vari...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Join a dynamic team to drive sales growth in the US SME market, owning the full sales cycle and translating complex fintech solutions into clear business value for diverse clients. Collaborate across...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.