Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$80K - $100K *

Unlock your potential by driving sales in the water restoration sector. Engage with customers, assess property needs, and provide tailored solutions while enjoying flexible schedules and unlimited ear...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$108K - $130K *

Lead product security and compliance initiatives, ensuring clients meet regulatory standards across diverse sectors. Drive client engagement, deliver assessments, and enhance cybersecurity resilience...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $90K *

Join a team that's dedicated to providing compassionate hospice care, collaborating with an interdisciplinary team to enhance the quality of life for patients and families facing terminal diagnoses th...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to designing impactful airport engineering projects. Collaborate on construction plans and technical specifications while enhancing your skills in a fast-paced environment...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Technical Services

$180K - $220K *

Advance global procurement initiatives by leading sourcing strategies for MRO and automotive parts. Drive operational excellence, enhance supplier relationships, and ensure compliance while achieving...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Transportation

$69K - $109K *

Advance your career by managing procurement strategies, supplier negotiations, and contract execution. Collaborate with teams to optimize supply chain performance and ensure compliance with industry s...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$105K - $147K *

Join us to accelerate progress at the forefront of software development for defense systems, engaging in the design, testing, and maintenance of robust solutions that support mission-critical operatio...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Accelerate progress at the forefront of security innovation by collaborating with leadership to enhance Continuous Threat Exposure Management, streamline remediation processes, and validate security c...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive national leadership in ambulatory care pharmacy services, enhancing medication safety and operational efficiency while overseeing training and compliance across diverse markets...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Shape the future of customer interactions by leading AI-driven solutions and system integrations. Collaborate with teams to design impactful journeys and optimize operational efficiency in a dynamic...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Shape the future of digital healthcare by managing the Epic/MyChart roadmap, optimizing patient engagement, and driving strategic enhancements to improve consumer access and experience in a complex en...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $125K *

Drive growth in the Data Center market by leading sales strategies, developing key relationships, and executing innovative initiatives to achieve market leadership in the West region. Shape the future...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Elevate talent development by diagnosing needs and leading high-impact learning initiatives. Collaborate with cross-functional teams to create engaging learning experiences that drive performance and...

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$89K - $129K *

Oversee quality assurance and field inspections for solar PV and energy storage projects, ensuring compliance and safety. Serve as the on-site representative for escalations, audits, and disaster reco...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$70K - $205K *

Transform digital experiences by building modern web applications with React and TypeScript. Collaborate across teams to deliver high-quality software while ensuring maintainability, performance, and...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$72K - $130K *

Optimize data integration by designing and delivering scalable ETL solutions. Collaborate with cross-functional teams to enhance healthcare technology through robust software applications and complex...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$60K - $107K *

Transform inpatient care management by assessing member needs and ensuring optimal health service utilization. Collaborate with healthcare professionals to enhance care progression and facilitate effe...

Kansas City, MORemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $120K *

Champion the operation of a Clinical and Pathology Laboratory, driving strategic improvements and ensuring compliance while leading a skilled team to deliver high-quality laboratory services and educa...

2 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $145K *

Explore the forefront of hematology/oncology as you engage with healthcare professionals, providing critical scientific insights and fostering relationships to support ADCT's innovative products and p...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive impactful agricultural economic research by managing complex projects, analyzing public policies on food access and nutrition, and leading a team of economists to enhance food security and marke...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$173K - $290K *

Lead the measurement strategy for platform impact, defining metrics and evaluations that drive actionable insights. Collaborate with engineering to operationalize data infrastructure, ensuring quality...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$170K - $187K *

Lead and manage clinical trials, ensuring compliance with protocols and regulations. Collaborate with cross-functional teams to achieve study milestones, maintain data quality, and resolve operational...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Drive impactful field marketing strategies across EMEA, collaborating with sales and stakeholders to execute integrated campaigns that enhance brand visibility and generate demand, while optimizing pe...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$104K - $136K *

Deliver impactful IAM solutions by managing program roadmaps, coordinating cross-functional teams, and leveraging AI tools to enhance identity and access management processes. Drive collaboration and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$97K - $131K *

Lead a dynamic sales strategy by managing key accounts and partnerships. Drive revenue growth through effective relationship building and strategic planning while achieving ambitious sales targets in...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.