Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $120K *

Champion efficient construction operations by leading field teams, managing subcontractors, and ensuring project compliance. Oversee multi-million dollar projects with a focus on safety, quality, and...

2 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$107K - $195K *

Join a team that's dedicated to enhancing national security through innovative project management. You'll lead cross-functional teams in a fast-paced Agile environment, ensuring timely delivery of sof...

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$154K - $278K *

Empower enterprise applications by assessing current landscapes and shaping strategic roadmaps. Collaborate with platform owners to ensure alignment with business processes and technology investments...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Technical Services

$120K - $145K *

Accelerate progress at the forefront of pricing strategy and operations. Lead cross-functional teams to innovate pricing models, enhance profitability, and drive market competitiveness while managing...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join a dynamic team to lead airport planning initiatives, manage projects, and collaborate with stakeholders. Utilize your expertise to develop master plans and enhance airport facilities, ensuring co...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Technical Services

$140K *

Champion client success by managing relationships, driving strategic initiatives, and ensuring satisfaction throughout the client journey. Collaborate with internal teams to deliver impactful solution...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$135K - $165K *

Develop and optimize software systems for military applications, ensuring compliance with industry standards and government regulations. Collaborate with cross-functional teams to deliver reliable sol...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K *

Join a dynamic sales team where you will source leads, exceed goals, and deliver exceptional customer service while building a profitable business. Enjoy a competitive earning potential and comprehens...

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $100K *

Empower client success by managing portfolios, ensuring operational efficiency, and supporting Client Managers. Develop essential skills in data accuracy and communication while contributing to high c...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Unlock potential by driving Brand P&L through strategic leadership and marketing execution across the Home and Garden division, achieving ambitious sales, GM, and EBITDA goals through integrated omnic...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$90K - $110K *

Transform patient care by delivering advanced palliative services in home settings. Collaborate with an interdisciplinary team to enhance quality of life for patients facing complex medical challenges...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$132K - $302K *

Drive the solution architecture vision for large-scale Salesforce Life Sciences programs, ensuring alignment across functional design and technical implementation while mentoring teams and engaging wi...

Reposted 2 days ago

  •   8 - 10 years exp.  •   Business Services

$87K - $293K *

Unlock your potential by leading SAP revenue transformation projects, collaborating with clients to enhance billing and accounting processes. Drive innovation in high-volume transaction environments a...

2 days ago

  •   5 - 7 years exp.  •   Business Services

$70K - $196K *

Champion enterprise-grade SAP data migration strategies, leveraging your expertise to design, implement, and optimize Master Data Governance processes while collaborating with clients and delivery tea...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$70K - $196K *

Unlock potential by leading SAP data migration initiatives, designing enterprise-grade strategies, and delivering integrated planning solutions. Collaborate across project lifecycles to modernize fina...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$116K - $174K *

Transform operations by leading teams to achieve strategic goals, ensuring compliance and quality standards while fostering a culture of belonging and continuous improvement. Drive financial performan...

2 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$94K - $266K *

Join a team that's driving strategic growth across the Americas. You'll analyze complex business challenges, develop actionable strategies, and collaborate with leadership to implement solutions that...

Reposted 2 days ago

  •   Less than 5 years exp.  •   Business Services

$134K - $201K *

Optimize the future of advanced therapies by driving complex CDMO deals, managing stakeholder relationships, and leveraging deep CGT expertise. Collaborate cross-functionally to promote growth and sha...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $145K *

Join a dynamic team to design, develop, and maintain full-stack applications, leveraging Python, AWS, and Terraform. Lead projects from ideation to deployment while mentoring junior engineers and ensu...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $147K *

Engage with a dynamic team to lead and develop property claims adjusters, enhancing their skills in coverage interpretation and customer communication while adapting to evolving claims processes and t...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$160K - $180K *

Join a team that's driving client success by managing strategic relationships and ensuring the financial health of key accounts. Leverage your expertise to bridge business goals with technical solutio...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $148K *

Drive the successful delivery of complex enterprise projects, ensuring timely execution and high-quality standards. Collaborate cross-functionally to meet client objectives and enhance project managem...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$115K - $140K *

Drive operational excellence and commercial readiness in a dynamic biotech environment. Collaborate cross-functionally to support launch activities, data management, and performance reporting, ensurin...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $185K *

Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.