Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$74K - $112K *

Empower your career with a pivotal role in technical support, delivering expert troubleshooting for gas engine systems. Collaborate globally to resolve issues, enhance customer satisfaction, and drive...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Empower growth by managing commercial real estate loans, analyzing financials, and fostering client relationships. Lead a team to ensure compliance and optimize portfolio performance while collaborati...

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Lead fundraising initiatives by developing strategic partnerships with corporations and foundations. Cultivate donor relationships, manage proposals, and drive philanthropic support to align with the...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$137K - $186K *

Unlock potential by leading cross-functional teams to deliver platform features that enhance global market capabilities. Drive localization efforts and ensure seamless integration across diverse regio...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$92K - $166K *

Join a team that's shaping the future of electric transmission design. Lead and mentor engineers while managing complex projects for major utilities. Drive innovation and quality in a dynamic, remote...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$137K - $210K *

Lead the profitability and risk strategy for a diverse Asset Protection portfolio. Shape underwriting governance and drive data-informed decisions to enhance product performance across multiple market...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$76K - $139K *

Join a team that's dedicated to designing innovative mechanical systems for healthcare and critical facilities. Collaborate with multidisciplinary teams to deliver high-performance solutions while adv...

2 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Empower our team by designing innovative solution architectures that align with business needs. Collaborate with stakeholders to assess requirements, conduct fit-gap analyses, and develop implementati...

2 days ago

  •   Less than 5 years exp.  •   Staffing

$174K - $374K *

Empower healthcare delivery by leading utilization management and appeals processes. Collaborate with a centralized team to ensure timely responses for members and providers, enhancing the quality of...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $102K *

Reimagine project management as you lead diverse MEP design operations, ensuring quality, timely delivery, and strong client relations across multiple sectors. Drive team performance while fostering p...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $145K *

Transform the future of application delivery by leading architecture and strategy for enterprise load balancing across hybrid and cloud environments, ensuring optimal performance and resiliency while...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in enhancing our security landscape through policy optimization, automation, and operational improvements across key platforms, while serving as the senior technical expert for complex...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in transforming healthcare insights into impactful creative campaigns, collaborating with cross-functional teams to design patient-centered solutions and integrating modern tools for e...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower reimbursement systems by developing and managing third-party calculations, preparing cost reports, and leading cross-functional teams to enhance net revenue management and compliance...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Elevate healthcare education by leading the development of innovative allied health programs. Drive growth and improvement through strategic partnerships, curriculum design, and compliance, ensuring l...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Accelerate growth by driving revenue through strategic sales of a digital payment platform to insurance carriers. Engage with C-level executives to foster relationships that enhance long-term success...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$59K - $177K *

Empower finance transformation by leading SAP S/4HANA initiatives, optimizing Record-to-Report processes, and collaborating with cross-functional teams to enhance financial operations and reporting in...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$91K - $119K *

Analyze and manage safety protocols for ammunition and explosives, ensuring compliance and risk mitigation across various contractor operations. Collaborate with stakeholders to enhance safety measure...

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$90K - $118K *

Lead the charge in ensuring safety and compliance in ammunition and explosives operations. Oversee risk management and collaborate with contractors to enhance safety protocols, while providing expert...

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$163K - $413K *

Transform client finance operations by leading SAP-based projects, leveraging your expertise to drive innovation and deliver impactful solutions. Collaborate with senior executives to define strategic...

2 days ago

  •   11 - 15 years exp.  •   Business Services

$66K - $104K *

Unlock potential by driving partner enablement and go-to-market strategies. Collaborate across teams to create impactful resources and campaigns that enhance client relationships and generate revenue...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $150K *

Lead the strategic alignment of R&D and IT, ensuring compliance and scalability of Veeva systems. Drive technology roadmaps, manage vendor relationships, and mentor junior partners while enhancing reg...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Empower customer success by leading a high-performing team to enhance support experiences, drive retention, and build proactive strategies. Shape the future of customer engagement through data-driven...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$95K - $115K *

Elevate the customer journey by managing tools and processes that enhance the customer experience. Lead initiatives across teams to optimize operations, drive product adoption, and ensure seamless col...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead and manage the Cardiovascular service line, ensuring alignment with organizational goals while enhancing employee engagement, patient experience, and operational efficiency. Drive strategic initi...

2 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.