Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $188K *

Join a team that's dedicated to transforming financial operations by analyzing data to identify cost-saving opportunities, enhancing margins, and improving cash flow through strategic recommendations...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$68K - $98K *

Transform inventory management by overseeing customer-owned and company assets. Collaborate with cross-functional teams to ensure material availability, accuracy, and compliance, directly impacting cu...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$120K - $145K *

Champion operational excellence by leading PMO governance and performance management initiatives. Drive cross-functional collaboration to enhance project execution, forecasting accuracy, and backlog c...

2 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $180K *

Shape the future of our Go-To-Market operations by owning and optimizing Salesforce. Collaborate with cross-functional teams to enhance sales processes, improve data quality, and drive efficiency acro...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $180K *

Lead strategic HR initiatives across 600+ stores, enhancing leadership, talent development, and organizational effectiveness while driving regional performance and fostering an inclusive culture...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$145K - $170K *

Pioneer innovative research at the intersection of AI and cybersecurity, tackling real-world security challenges. Collaborate with diverse teams to develop prototypes and experiments that influence cu...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead operations across multiple rural health clinics, driving patient care and team performance while collaborating with physicians to enhance community health outcomes and operational success...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$93K - $123K *

Shape the future of regulatory submissions by coordinating U.S. FDA filings for investigational and commercial products. Collaborate with cross-functional teams to ensure timely, compliant submissions...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Engage with healthcare professionals to provide scientific insights on ADCT products. Develop relationships with KOLs and support medical affairs objectives while maintaining ethical standards in a dy...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in developing and executing a comprehensive maintenance and asset health strategy across multiple manufacturing sites, enhancing reliability and performance while fostering a culture o...

2 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$135K - $155K *

Elevate your career by designing scalable healthcare data solutions. Collaborate with enterprise clients to uncover needs and guide architecture, ensuring alignment with best practices and regulatory...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$81K - $103K *

Drive excellence in animal feed safety by conducting third-party audits, ensuring compliance with industry standards, and collaborating with audit teams to enhance certification processes and customer...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Champion partner success by leading a dedicated team to enhance customer relationships, drive program delivery, and ensure operational excellence across educational assessments, fostering a culture of...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$230K - $290K *

Join a team that's dedicated to enhancing account security through innovative solutions. You'll lead technical strategies, collaborate across teams, and foster a culture of quality while ensuring seam...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$89K - $169K *

Lead the charge in managing complex client relationships, driving growth and retention through strategic planning and execution. Utilize expertise to implement customized service strategies and enhanc...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$112K - $172K *

Lead the charge in cybersecurity operations, managing teams to protect critical infrastructure from cyber threats while advising on strategic risk management and fostering partnerships across federal...

2 days ago

  •   Less than 5 years exp.  •   Transportation

$100K - $129K *

Drive your career with a Senior Network Administrator role, managing and optimizing enterprise network infrastructure. Collaborate across teams to ensure security, performance, and scalability while l...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Transportation

$103K - $146K *

Join a team that's driving innovation in construction management. Oversee project profitability and success from estimates to completion, ensuring quality and timely delivery while fostering strong re...

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$66K - $127K *

Shape the future of pharmaceutical marketing by leading PRC operations, ensuring compliance, and driving process improvements. Collaborate cross-functionally to enhance promotional material review and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$185K *

Drive growth by leading a team of Strategic Account Managers to enhance enterprise account value through cross-sell and upsell strategies, fostering executive relationships and achieving expansion goa...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $90K *

Optimize sourcing strategies and supplier relationships to drive value across regions. Lead negotiations, manage contracts, and collaborate with stakeholders to enhance procurement processes and maxim...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Shape the future of financial analysis by providing critical insights into pricing, profitability, and forecasting. Collaborate with cross-functional teams to enhance decision-making and drive busines...

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$74K - $112K *

Empower your career with a pivotal role in technical support, delivering expert troubleshooting for gas engine systems. Collaborate globally to resolve issues, enhance customer satisfaction, and drive...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Empower growth by managing commercial real estate loans, analyzing financials, and fostering client relationships. Lead a team to ensure compliance and optimize portfolio performance while collaborati...

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Lead fundraising initiatives by developing strategic partnerships with corporations and foundations. Cultivate donor relationships, manage proposals, and drive philanthropic support to align with the...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.