Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$130K - $155K *

Innovate and lead the development of a comprehensive IAM program, collaborating across teams to enhance identity governance and security. Manage a skilled team while ensuring compliance and effective...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Elevate project delivery by managing multiple concurrent engagements, ensuring timely execution and quality. Collaborate with teams to drive client satisfaction and optimize resources while maintainin...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$108K - $140K *

Unlock potential by leading verification and validation for regulated medical device software. Collaborate with cross-functional teams to ensure compliance and quality in bioinformatics and lab automa...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Transform your career by modernizing legacy applications and integrating AI solutions. Collaborate with cross-functional teams to design, develop, and enhance software that boosts efficiency and drive...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $105K *

Engage with a dynamic Inside Sales Team, driving strategies to enhance customer acquisition and retention. Lead initiatives that maximize sales revenue and market share while fostering collaboration w...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Champion exceptional sales strategies by engaging with pre-qualified leads, conducting assessments, and delivering tailored sewer line solutions for residential and commercial clients, all while enjoy...

2 days ago

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Lead complex Logis Dispatch implementations from kickoff to handoff, ensuring dispatch centers go live smoothly. Collaborate with teams to configure systems, train users, and mentor consultants while...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $170K *

Drive strategic partnerships by leading growth initiatives, enhancing partner relationships, and executing annual strategies. Collaborate cross-functionally to optimize performance, improve satisfacti...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Shape the future of contract management in aerospace and defense. Leverage your expertise in Dassian and SAP S/4HANA to enhance contract lifecycle processes, ensuring compliance and efficiency in gove...

2 days ago

  •   Less than 5 years exp.  •   Staffing

$144K - $220K *

Drive technical excellence as a Senior Staff Engineer, leading the Ops Portal team in shaping architecture and product direction across multiple platforms, while ensuring robust, scalable solutions fo...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$69K - $119K *

Elevate your career by managing diverse projects in healthcare, ensuring timely delivery and quality. Collaborate with teams to implement best practices, drive innovation, and enhance client experienc...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$126K - $173K *

Drive integration strategies to enhance silicon photonic fabrication, collaborating with foundries to evolve processes from development to production while ensuring robust performance and reproducibil...

RemoteRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Information Technology

$88K - $105K *

Drive marketing excellence by leading pursuit strategies, enhancing client engagement, and optimizing proposal processes. Collaborate cross-functionally to implement best practices and elevate brand p...

2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$85K - $95K *

Champion data-driven insights by modernizing analytics through AI automation. Leverage SQL and BI tools to transform complex data into actionable reports, ensuring clarity and accuracy for leadership...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Media

$80K - $95K *

Drive operational excellence by leading grants management, compliance, and program evaluation. Oversee data systems and risk prevention while ensuring accountability and stewardship of resources to su...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$175K - $200K *

Join a dynamic team to manage strategic supplier partnerships, ensuring alignment with growth objectives and operational needs in a fast-paced cloud infrastructure environment. Drive collaboration and...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Shape impactful brand experiences by integrating audience insights into creative campaigns. Collaborate with cross-functional teams to enhance workflows using generative AI tools, ensuring consistency...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to enhancing clinical imaging support by providing expert troubleshooting and proactive solutions to ensure seamless operations for radiologists and clinical staff...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$222K - $299K *

Grow your career with a leadership role overseeing national acute care pharmacy operations, driving standardization and continuous improvement across 90 hospitals while developing pharmacy talent and...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$188K - $235K *

Grow your career with a hands-on leadership role in GTM analytics, driving data-driven decisions across Sales, Marketing, and Customer Success. Shape analytics products and insights to enhance pipelin...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$94K - $146K *

Transform cybersecurity by leading comprehensive penetration testing engagements, identifying vulnerabilities, and delivering actionable insights to clients while mentoring junior talent and advancing...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Manage HR operations by supervising staff, advising leadership on personnel matters, and enhancing workforce management practices to improve organizational efficiency and compliance with federal regul...

2 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Advance complex electrical equipment projects by leading teams, managing scope, cost, and schedules. Drive execution and ensure milestones are met while fostering collaboration across stakeholders in...

2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$87K - $293K *

Champion operational excellence by leading supply chain improvements, enhancing performance management, and fostering client relationships across logistics and distribution environments. Drive measura...

Reposted 2 days ago

  •   5 - 7 years exp.  •   Business Services

$95K - $188K *

Analyze financial and operational data to drive cost reduction and margin improvement. Collaborate with clients to implement transformative strategies, build business cases, and enhance operational ef...

2 days ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.