Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Unlock potential by leading financial analysis and reporting initiatives that drive strategic decision-making, bolstering executive insights and enhancing long-term value within the finance sector...

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$68K - $114K *

Unlock potential by crafting engaging communications that enhance employee engagement and support business priorities through effective content development and collaboration with stakeholders across m...

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock potential by driving cross-functional initiatives in Fixed Income Trading. Collaborate with diverse teams to enhance business execution, manage risks, and ensure compliance while navigating a d...

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$185K - $254K *

Transform the oncology sales landscape by leading a dynamic team, driving strategic initiatives, and fostering relationships with key healthcare stakeholders to achieve business objectives and enhance...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$85K - $92K *

Transform patient care by delivering compassionate nursing services in diverse settings. Collaborate with an interdisciplinary team to enhance quality of life for patients in hospice and home health e...

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$175K - $270K *

Advance client relationships by identifying growth opportunities and leading the sales cycle. Collaborate cross-functionally to design solutions that meet client needs and drive revenue, ensuring long...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$95K - $123K *

Redefine HR compliance by leading programs that ensure adherence to federal, state, and local regulations. Collaborate with cross-functional teams to enhance operational effectiveness and mitigate com...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $145K *

Lead the charge in developing high-performance, secure cloud components while collaborating with stakeholders to enhance data products and mentor junior engineers in an agile environment...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by delivering expert oncology pharmacy services across infusion centers and inpatient settings, ensuring optimal patient care through collaboration, critical thinking, and advanced pr...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Empower healthcare by joining a collaborative team of infectious disease physicians, providing comprehensive inpatient and outpatient care with shared on-call responsibilities, and enjoying a balanced...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$196K - $294K *

Empower the EMD franchise by leading learning strategies and operational execution, driving measurable impact across commercial, medical, and market access teams while fostering a high-performing cult...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$268K - $402K *

Champion the epilepsy pipeline by leading global medical strategies, ensuring regional insights drive clinical development and evidence generation. Collaborate across teams to address healthcare needs...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$196K - $294K *

Unlock potential by leading innovative learning strategies for the Sleep franchise, driving operational excellence and measurable impact across commercial, medical, and market access teams while foste...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$78K - $88K *

Optimize your career by developing innovative AI/ML applications. Collaborate with diverse teams to enhance software tools that drive sales effectiveness and efficiency. Contribute to the entire softw...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Drive global strategy and process design for Quote to Order workflows. Collaborate across teams to enhance operational efficiency, resolve bottlenecks, and ensure seamless tool adoption for a scalable...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$135K - $155K *

Innovate cutting-edge firmware solutions for advanced video security products. Collaborate with cross-functional teams to design, develop, and enhance embedded systems, ensuring high-quality performan...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$112K - $135K *

Join a team that's innovating healthcare solutions by developing cutting-edge network messaging software. Collaborate with diverse engineers to enhance patient experiences while enjoying a positive wo...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$113K - $176K *

Lead procurement efforts for large-scale gas generation and renewable projects, ensuring alignment with project timelines and budgets. Manage a team, oversee supply chain activities, and drive process...

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$131K - $204K *

Lead the charge in managing multi-party project interfaces, ensuring timely delivery and adherence to scope and budget. Supervise a dedicated team while driving continuous improvement in project manag...

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$88K - $137K *

Develop and enhance enterprise-wide governance practices, ensuring compliance and operational consistency by maintaining accurate documentation aligned with regulatory standards across various busines...

Reposted yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$131K - $204K *

Shape the future of project management by leading a dynamic team to oversee cost, schedule, and risk across major projects. Drive compliance and enhance project health through strategic planning and e...

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$134K - $168K *

Join a team that's transforming operational data into reliable customer experiences. As a Senior Machine Learning Engineer, you'll lead the development of innovative machine learning solutions, enhanc...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$94K - $120K *

Elevate your career by leading the optimization of EMR applications, enhancing laboratory workflows, and ensuring efficient patient care delivery through collaboration with clinical and technical team...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$88K - $120K *

Lead the charge in managing and developing high-performing sales teams to drive revenue growth and enhance client relationships. Collaborate across departments to implement strategic plans that ensure...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$94K - $128K *

Unlock potential by leading sales teams to drive revenue growth and enhance client relationships. Utilize strategic insights and industry knowledge to cultivate partnerships, manage performance, and a...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.