Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$144K - $220K *

Drive technical excellence as a Senior Staff Engineer, leading the Ops Portal team in shaping architecture and product direction across multiple platforms, while ensuring robust, scalable solutions fo...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$69K - $119K *

Elevate your career by managing diverse projects in healthcare, ensuring timely delivery and quality. Collaborate with teams to implement best practices, drive innovation, and enhance client experienc...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$126K - $173K *

Drive integration strategies to enhance silicon photonic fabrication, collaborating with foundries to evolve processes from development to production while ensuring robust performance and reproducibil...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Information Technology

$88K - $105K *

Drive marketing excellence by leading pursuit strategies, enhancing client engagement, and optimizing proposal processes. Collaborate cross-functionally to implement best practices and elevate brand p...

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$85K - $95K *

Champion data-driven insights by modernizing analytics through AI automation. Leverage SQL and BI tools to transform complex data into actionable reports, ensuring clarity and accuracy for leadership...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Media

$80K - $95K *

Drive operational excellence by leading grants management, compliance, and program evaluation. Oversee data systems and risk prevention while ensuring accountability and stewardship of resources to su...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$175K - $200K *

Join a dynamic team to manage strategic supplier partnerships, ensuring alignment with growth objectives and operational needs in a fast-paced cloud infrastructure environment. Drive collaboration and...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Shape impactful brand experiences by integrating audience insights into creative campaigns. Collaborate with cross-functional teams to enhance workflows using generative AI tools, ensuring consistency...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to enhancing clinical imaging support by providing expert troubleshooting and proactive solutions to ensure seamless operations for radiologists and clinical staff...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$222K - $299K *

Grow your career with a leadership role overseeing national acute care pharmacy operations, driving standardization and continuous improvement across 90 hospitals while developing pharmacy talent and...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$188K - $235K *

Grow your career with a hands-on leadership role in GTM analytics, driving data-driven decisions across Sales, Marketing, and Customer Success. Shape analytics products and insights to enhance pipelin...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$94K - $146K *

Transform cybersecurity by leading comprehensive penetration testing engagements, identifying vulnerabilities, and delivering actionable insights to clients while mentoring junior talent and advancing...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Manage HR operations by supervising staff, advising leadership on personnel matters, and enhancing workforce management practices to improve organizational efficiency and compliance with federal regul...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Advance complex electrical equipment projects by leading teams, managing scope, cost, and schedules. Drive execution and ensure milestones are met while fostering collaboration across stakeholders in...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$87K - $293K *

Champion operational excellence by leading supply chain improvements, enhancing performance management, and fostering client relationships across logistics and distribution environments. Drive measura...

Reposted yesterday

  •   5 - 7 years exp.  •   Business Services

$95K - $188K *

Analyze financial and operational data to drive cost reduction and margin improvement. Collaborate with clients to implement transformative strategies, build business cases, and enhance operational ef...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$95K - $188K *

Join a team that's dedicated to transforming financial operations by analyzing data to identify cost-saving opportunities, enhancing margins, and improving cash flow through strategic recommendations...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$68K - $98K *

Transform inventory management by overseeing customer-owned and company assets. Collaborate with cross-functional teams to ensure material availability, accuracy, and compliance, directly impacting cu...

Yesterday

  •   Less than 5 years exp.  •   Transportation

$120K - $145K *

Champion operational excellence by leading PMO governance and performance management initiatives. Drive cross-functional collaboration to enhance project execution, forecasting accuracy, and backlog c...

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $180K *

Shape the future of our Go-To-Market operations by owning and optimizing Salesforce. Collaborate with cross-functional teams to enhance sales processes, improve data quality, and drive efficiency acro...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $180K *

Lead strategic HR initiatives across 600+ stores, enhancing leadership, talent development, and organizational effectiveness while driving regional performance and fostering an inclusive culture...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$145K - $170K *

Pioneer innovative research at the intersection of AI and cybersecurity, tackling real-world security challenges. Collaborate with diverse teams to develop prototypes and experiments that influence cu...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead operations across multiple rural health clinics, driving patient care and team performance while collaborating with physicians to enhance community health outcomes and operational success...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$93K - $123K *

Shape the future of regulatory submissions by coordinating U.S. FDA filings for investigational and commercial products. Collaborate with cross-functional teams to ensure timely, compliant submissions...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Engage with healthcare professionals to provide scientific insights on ADCT products. Develop relationships with KOLs and support medical affairs objectives while maintaining ethical standards in a dy...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.