Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $114,671
Senior Staff Software Engineer, Android & IoT
$144K - $220K *
Drive technical excellence as a Senior Staff Engineer, leading the Ops Portal team in shaping architecture and product direction across multiple platforms, while ensuring robust, scalable solutions fo...
Yesterday
$69K - $119K *
Elevate your career by managing diverse projects in healthcare, ensuring timely delivery and quality. Collaborate with teams to implement best practices, drive innovation, and enhance client experienc...
Yesterday
Senior Foundry Integration Engineer
$126K - $173K *
Drive integration strategies to enhance silicon photonic fabrication, collaborating with foundries to evolve processes from development to production while ensuring robust performance and reproducibil...
Reposted yesterday
Marketing Manager - Pursuit Excellence
$88K - $105K *
Drive marketing excellence by leading pursuit strategies, enhancing client engagement, and optimizing proposal processes. Collaborate cross-functionally to implement best practices and elevate brand p...
Yesterday
Senior Business Intelligence Analyst - AI & Automation
$85K - $95K *
Champion data-driven insights by modernizing analytics through AI automation. Leverage SQL and BI tools to transform complex data into actionable reports, ensuring clarity and accuracy for leadership...
Yesterday
Director of Organizational Operations
$80K - $95K *
Drive operational excellence by leading grants management, compliance, and program evaluation. Oversee data systems and risk prevention while ensuring accountability and stewardship of resources to su...
Yesterday
$175K - $200K *
Join a dynamic team to manage strategic supplier partnerships, ensuring alignment with growth objectives and operational needs in a fast-paced cloud infrastructure environment. Drive collaboration and...
Yesterday
Senior Brand Experience Strategist
$95K - $115K *
Shape impactful brand experiences by integrating audience insights into creative campaigns. Collaborate with cross-functional teams to enhance workflows using generative AI tools, ensuring consistency...
Yesterday
$80K - $95K *
Join a team that's dedicated to enhancing clinical imaging support by providing expert troubleshooting and proactive solutions to ensure seamless operations for radiologists and clinical staff...
Yesterday
AVP-Acute Care Pharmacy Operations
$222K - $299K *
Grow your career with a leadership role overseeing national acute care pharmacy operations, driving standardization and continuous improvement across 90 hospitals while developing pharmacy talent and...
Yesterday
$188K - $235K *
Grow your career with a hands-on leadership role in GTM analytics, driving data-driven decisions across Sales, Marketing, and Customer Success. Shape analytics products and insights to enhance pipelin...
Yesterday
Senior Penetration Tester & Cyber Compliance Consultant
$94K - $146K *
Transform cybersecurity by leading comprehensive penetration testing engagements, identifying vulnerabilities, and delivering actionable insights to clients while mentoring junior talent and advancing...
Yesterday
Supervisory Management Analyst
$95K - $115K *
Manage HR operations by supervising staff, advising leadership on personnel matters, and enhancing workforce management practices to improve organizational efficiency and compliance with federal regul...
Yesterday
Manager - Project Management (Grid Services)
$95K - $115K *
Advance complex electrical equipment projects by leading teams, managing scope, cost, and schedules. Drive execution and ensure milestones are met while fostering collaboration across stakeholders in...
Yesterday
Supply Chain and Engineering Consulting - Logistics & Fulfillment (JTG) Manager
$87K - $293K *
Champion operational excellence by leading supply chain improvements, enhancing performance management, and fostering client relationships across logistics and distribution environments. Drive measura...
Reposted yesterday
Performance & Cost Improvement Consultant
$95K - $188K *
Analyze financial and operational data to drive cost reduction and margin improvement. Collaborate with clients to implement transformative strategies, build business cases, and enhance operational ef...
Yesterday
Performance & Cost Improvement Consultant
$95K - $188K *
Join a team that's dedicated to transforming financial operations by analyzing data to identify cost-saving opportunities, enhancing margins, and improving cash flow through strategic recommendations...
Yesterday
$68K - $98K *
Transform inventory management by overseeing customer-owned and company assets. Collaborate with cross-functional teams to ensure material availability, accuracy, and compliance, directly impacting cu...
Yesterday
Manager Project Management (PMO) North America
$120K - $145K *
Champion operational excellence by leading PMO governance and performance management initiatives. Drive cross-functional collaboration to enhance project execution, forecasting accuracy, and backlog c...
Yesterday
Senior Salesforce Administrator (GTM)
$140K - $180K *
Shape the future of our Go-To-Market operations by owning and optimizing Salesforce. Collaborate with cross-functional teams to enhance sales processes, improve data quality, and drive efficiency acro...
Yesterday
Regional HR Director - North East
$135K - $180K *
Lead strategic HR initiatives across 600+ stores, enhancing leadership, talent development, and organizational effectiveness while driving regional performance and fostering an inclusive culture...
Yesterday
Research Staff, Adversarial Intelligence
$145K - $170K *
Pioneer innovative research at the intersection of AI and cybersecurity, tackling real-world security challenges. Collaborate with diverse teams to develop prototypes and experiments that influence cu...
Yesterday
Practice Administrator - Rural Clinics
$80K - $95K *
Lead operations across multiple rural health clinics, driving patient care and team performance while collaborating with physicians to enhance community health outcomes and operational success...
Yesterday
Senior Associate, Regulatory Affairs - US
$93K - $123K *
Shape the future of regulatory submissions by coordinating U.S. FDA filings for investigational and commercial products. Collaborate with cross-functional teams to ensure timely, compliant submissions...
Yesterday
Medical Science Liaison (Carolinas)
$120K - $145K *
Engage with healthcare professionals to provide scientific insights on ADCT products. Develop relationships with KOLs and support medical affairs objectives while maintaining ethical standards in a dy...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.