Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$94K - $128K *

Lead and optimize sales teams to drive revenue growth and enhance client relationships. Collaborate with cross-functional teams to implement strategic plans, ensuring customer success and market expan...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join the charge in advancing ballistic armor systems through lifecycle management, testing, and evaluation. Leverage your expertise to ensure the highest standards of safety and performance in persona...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Unlock your potential by driving enterprise sales within the Department of Defense. Engage with senior leaders to enhance mission effectiveness through innovative Experience Management solutions, whil...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Lead the charge in managing medical/scientific research services, overseeing operations, budget, and collection development while collaborating with litigation teams to enhance trial preparation and r...

Yesterday

  •   8 - 10 years exp.  •   Legal & Accounting

$165K - $243K *

Elevate healthcare data solutions by leading a team of engineers to deliver scalable data infrastructure, ensuring compliance and operational excellence while translating stakeholder needs into action...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$200K - $300K *

Analyze and execute complex tax and preferred equity transactions in renewable energy. Lead underwriting, model development, and investment analysis while mentoring team members and driving projects f...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$300K - $500K *

Inspire growth by building relationships with buyers, educating them on tax credit transactions, and leveraging the Crux platform to enhance outcomes. Drive new leads and partnerships while navigating...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $180K *

Lead the design and implementation of warehouse solutions, guiding teams through the Tecsys Elite WMS architecture. Drive integration, configuration, and continuous improvement while ensuring operatio...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Transportation

$110K - $130K *

Transform your career by driving market development in quantum technology. Engage with strategic accounts and forge strong relationships while identifying new business opportunities and expanding exis...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$90K - $160K *

Transform healthcare integration as you lead technical implementations, optimize methodologies, and ensure successful ECG system configurations while supporting clients with your expertise in interfac...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $88K *

Drive sales initiatives and enhance customer relationships while supporting independent channels. Collaborate with teams to meet KPIs, conduct market research, and create impactful sales materials in...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$180K - $225K *

Elevate the future of AI systems by architecting LLM-powered workflows that enhance customer interactions, ensuring security and performance while guiding teams through complex challenges and deliveri...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$95K - $193K *

Elevate Paid Media strategies across a diverse portfolio, ensuring alignment with digital marketing goals. Lead investment management, agency collaboration, and performance oversight to drive impactfu...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Innovate and lead full-stack application development across diverse sectors, ensuring secure, scalable solutions. Collaborate with teams to transform concepts into market-ready products while establis...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$119K - $208K *

Explore an opportunity to lead security initiatives for a satellite broadband project. Drive the design and operation of PKI systems, ensuring compliance and security while collaborating with diverse...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Lead the charge in driving growth within the territory by building strong customer relationships, expanding key accounts, and delivering tailored water treatment solutions to meet complex challenges i...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $155K *

Innovate and lead the development of a comprehensive IAM program, collaborating across teams to enhance identity governance and security. Manage a skilled team while ensuring compliance and effective...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Elevate project delivery by managing multiple concurrent engagements, ensuring timely execution and quality. Collaborate with teams to drive client satisfaction and optimize resources while maintainin...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$108K - $140K *

Unlock potential by leading verification and validation for regulated medical device software. Collaborate with cross-functional teams to ensure compliance and quality in bioinformatics and lab automa...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $120K *

Transform your career by modernizing legacy applications and integrating AI solutions. Collaborate with cross-functional teams to design, develop, and enhance software that boosts efficiency and drive...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$84K - $105K *

Engage with a dynamic Inside Sales Team, driving strategies to enhance customer acquisition and retention. Lead initiatives that maximize sales revenue and market share while fostering collaboration w...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Champion exceptional sales strategies by engaging with pre-qualified leads, conducting assessments, and delivering tailored sewer line solutions for residential and commercial clients, all while enjoy...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Lead complex Logis Dispatch implementations from kickoff to handoff, ensuring dispatch centers go live smoothly. Collaborate with teams to configure systems, train users, and mentor consultants while...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$150K - $170K *

Drive strategic partnerships by leading growth initiatives, enhancing partner relationships, and executing annual strategies. Collaborate cross-functionally to optimize performance, improve satisfacti...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Shape the future of contract management in aerospace and defense. Leverage your expertise in Dassian and SAP S/4HANA to enhance contract lifecycle processes, ensuring compliance and efficiency in gove...

Yesterday

  •   Less than 5 years exp.  •   Staffing

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.