Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$100K - $129K *

Drive your career with a Senior Network Administrator role, managing and optimizing enterprise network infrastructure. Collaborate across teams to ensure security, performance, and scalability while l...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Transportation

$103K - $146K *

Join a team that's driving innovation in construction management. Oversee project profitability and success from estimates to completion, ensuring quality and timely delivery while fostering strong re...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$66K - $127K *

Shape the future of pharmaceutical marketing by leading PRC operations, ensuring compliance, and driving process improvements. Collaborate cross-functionally to enhance promotional material review and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$185K *

Drive growth by leading a team of Strategic Account Managers to enhance enterprise account value through cross-sell and upsell strategies, fostering executive relationships and achieving expansion goa...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $90K *

Optimize sourcing strategies and supplier relationships to drive value across regions. Lead negotiations, manage contracts, and collaborate with stakeholders to enhance procurement processes and maxim...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Transportation

$80K - $95K *

Shape the future of financial analysis by providing critical insights into pricing, profitability, and forecasting. Collaborate with cross-functional teams to enhance decision-making and drive busines...

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$74K - $112K *

Empower your career with a pivotal role in technical support, delivering expert troubleshooting for gas engine systems. Collaborate globally to resolve issues, enhance customer satisfaction, and drive...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Empower growth by managing commercial real estate loans, analyzing financials, and fostering client relationships. Lead a team to ensure compliance and optimize portfolio performance while collaborati...

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Lead fundraising initiatives by developing strategic partnerships with corporations and foundations. Cultivate donor relationships, manage proposals, and drive philanthropic support to align with the...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$137K - $186K *

Unlock potential by leading cross-functional teams to deliver platform features that enhance global market capabilities. Drive localization efforts and ensure seamless integration across diverse regio...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Legal & Accounting

$92K - $166K *

Join a team that's shaping the future of electric transmission design. Lead and mentor engineers while managing complex projects for major utilities. Drive innovation and quality in a dynamic, remote...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Technical Services

$137K - $210K *

Lead the profitability and risk strategy for a diverse Asset Protection portfolio. Shape underwriting governance and drive data-informed decisions to enhance product performance across multiple market...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$76K - $139K *

Join a team that's dedicated to designing innovative mechanical systems for healthcare and critical facilities. Collaborate with multidisciplinary teams to deliver high-performance solutions while adv...

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Empower our team by designing innovative solution architectures that align with business needs. Collaborate with stakeholders to assess requirements, conduct fit-gap analyses, and develop implementati...

Yesterday

  •   Less than 5 years exp.  •   Staffing

$174K - $374K *

Empower healthcare delivery by leading utilization management and appeals processes. Collaborate with a centralized team to ensure timely responses for members and providers, enhancing the quality of...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $102K *

Reimagine project management as you lead diverse MEP design operations, ensuring quality, timely delivery, and strong client relations across multiple sectors. Drive team performance while fostering p...

Reposted yesterday

  •   5 - 7 years exp.  •   Technical Services

$120K - $145K *

Transform the future of application delivery by leading architecture and strategy for enterprise load balancing across hybrid and cloud environments, ensuring optimal performance and resiliency while...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in enhancing our security landscape through policy optimization, automation, and operational improvements across key platforms, while serving as the senior technical expert for complex...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Lead the charge in transforming healthcare insights into impactful creative campaigns, collaborating with cross-functional teams to design patient-centered solutions and integrating modern tools for e...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower reimbursement systems by developing and managing third-party calculations, preparing cost reports, and leading cross-functional teams to enhance net revenue management and compliance...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $90K *

Elevate healthcare education by leading the development of innovative allied health programs. Drive growth and improvement through strategic partnerships, curriculum design, and compliance, ensuring l...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $150K *

Accelerate growth by driving revenue through strategic sales of a digital payment platform to insurance carriers. Engage with C-level executives to foster relationships that enhance long-term success...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$59K - $177K *

Empower finance transformation by leading SAP S/4HANA initiatives, optimizing Record-to-Report processes, and collaborating with cross-functional teams to enhance financial operations and reporting in...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$91K - $119K *

Analyze and manage safety protocols for ammunition and explosives, ensuring compliance and risk mitigation across various contractor operations. Collaborate with stakeholders to enhance safety measure...

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$90K - $118K *

Lead the charge in ensuring safety and compliance in ammunition and explosives operations. Oversee risk management and collaborate with contractors to enhance safety protocols, while providing expert...

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.