Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $114,671

Sort By: Relevance

$95K - $115K *

Shape impactful brand experiences by integrating audience insights into creative campaigns. Collaborate with cross-functional teams to enhance workflows using generative AI tools, ensuring consistency...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to enhancing clinical imaging support by providing expert troubleshooting and proactive solutions to ensure seamless operations for radiologists and clinical staff...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$222K - $299K *

Grow your career with a leadership role overseeing national acute care pharmacy operations, driving standardization and continuous improvement across 90 hospitals while developing pharmacy talent and...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$188K - $235K *

Grow your career with a hands-on leadership role in GTM analytics, driving data-driven decisions across Sales, Marketing, and Customer Success. Shape analytics products and insights to enhance pipelin...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$94K - $146K *

Transform cybersecurity by leading comprehensive penetration testing engagements, identifying vulnerabilities, and delivering actionable insights to clients while mentoring junior talent and advancing...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Manage HR operations by supervising staff, advising leadership on personnel matters, and enhancing workforce management practices to improve organizational efficiency and compliance with federal regul...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Advance complex electrical equipment projects by leading teams, managing scope, cost, and schedules. Drive execution and ensure milestones are met while fostering collaboration across stakeholders in...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$87K - $293K *

Champion operational excellence by leading supply chain improvements, enhancing performance management, and fostering client relationships across logistics and distribution environments. Drive measura...

Reposted yesterday

  •   5 - 7 years exp.  •   Business Services

$95K - $188K *

Analyze financial and operational data to drive cost reduction and margin improvement. Collaborate with clients to implement transformative strategies, build business cases, and enhance operational ef...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$95K - $188K *

Join a team that's dedicated to transforming financial operations by analyzing data to identify cost-saving opportunities, enhancing margins, and improving cash flow through strategic recommendations...

Yesterday

  •   Less than 5 years exp.  •   Business Services

$68K - $98K *

Transform inventory management by overseeing customer-owned and company assets. Collaborate with cross-functional teams to ensure material availability, accuracy, and compliance, directly impacting cu...

Yesterday

  •   Less than 5 years exp.  •   Transportation

$120K - $145K *

Champion operational excellence by leading PMO governance and performance management initiatives. Drive cross-functional collaboration to enhance project execution, forecasting accuracy, and backlog c...

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$140K - $180K *

Shape the future of our Go-To-Market operations by owning and optimizing Salesforce. Collaborate with cross-functional teams to enhance sales processes, improve data quality, and drive efficiency acro...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $180K *

Lead strategic HR initiatives across 600+ stores, enhancing leadership, talent development, and organizational effectiveness while driving regional performance and fostering an inclusive culture...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$145K - $170K *

Pioneer innovative research at the intersection of AI and cybersecurity, tackling real-world security challenges. Collaborate with diverse teams to develop prototypes and experiments that influence cu...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Lead operations across multiple rural health clinics, driving patient care and team performance while collaborating with physicians to enhance community health outcomes and operational success...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$93K - $123K *

Shape the future of regulatory submissions by coordinating U.S. FDA filings for investigational and commercial products. Collaborate with cross-functional teams to ensure timely, compliant submissions...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Engage with healthcare professionals to provide scientific insights on ADCT products. Develop relationships with KOLs and support medical affairs objectives while maintaining ethical standards in a dy...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in developing and executing a comprehensive maintenance and asset health strategy across multiple manufacturing sites, enhancing reliability and performance while fostering a culture o...

Yesterday

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$135K - $155K *

Elevate your career by designing scalable healthcare data solutions. Collaborate with enterprise clients to uncover needs and guide architecture, ensuring alignment with best practices and regulatory...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$81K - $103K *

Drive excellence in animal feed safety by conducting third-party audits, ensuring compliance with industry standards, and collaborating with audit teams to enhance certification processes and customer...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$95K - $115K *

Champion partner success by leading a dedicated team to enhance customer relationships, drive program delivery, and ensure operational excellence across educational assessments, fostering a culture of...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$230K - $290K *

Join a team that's dedicated to enhancing account security through innovative solutions. You'll lead technical strategies, collaborate across teams, and foster a culture of quality while ensuring seam...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$89K - $169K *

Lead the charge in managing complex client relationships, driving growth and retention through strategic planning and execution. Utilize expertise to implement customized service strategies and enhanc...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$112K - $172K *

Lead the charge in cybersecurity operations, managing teams to protect critical infrastructure from cyber threats while advising on strategic risk management and fostering partnerships across federal...

Yesterday

  •   Less than 5 years exp.  •   Transportation

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.