Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Jobs in Missouri

Average Salary in USD

Average Salary: $116,335

Sort By: Relevance

$136K - $265K *

Unlock potential by designing and securing advanced trust architectures across devices and cloud platforms. Collaborate with engineering teams to enhance security measures, conduct threat modeling, an...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$80K - $95K *

Join a dynamic team to enhance automation systems, troubleshoot PLCs, and lead modernization projects. Supervise production staff while driving equipment reliability and process improvements in a fast...

Today

  •   5 - 7 years exp.  •   Food & Beverages

$170K - $207K *

Join a dynamic team to drive product vision and strategy for innovative solutions in the short-term rental market. Collaborate across departments to enhance customer experience and deliver impactful f...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$95K - $115K *

Shape the future of supplier quality in mechanical engineering by overseeing the quality assurance of critical components and systems. Collaborate with suppliers to ensure compliance, execute testing...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Take ownership of supplier quality for mechanical components, ensuring compliance from qualification through Factory Acceptance Testing. Collaborate with suppliers to uphold standards, manage inspecti...

Today

  •   5 - 7 years exp.  •   Energy & Utilities

$88K - $105K *

Drive risk assessments and vulnerability testing to enhance application security. Collaborate with IT teams to implement security solutions, prepare reports, and ensure compliance with regulations whi...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $160K *

Transform your career by leading global product development initiatives, enhancing quality and compliance while driving innovation and operational efficiency across cross-functional teams...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$90K - $147K *

Transform pediatric care by specializing in weight management and collaborating with endocrinologists. Engage in teaching while providing comprehensive medical support to young patients in a dynamic...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$101K - $126K *

Join our team as a Lead System Administrator, overseeing global IT systems infrastructure. You'll ensure data integrity, manage a diverse team, and implement compliance frameworks while driving operat...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$120K - $145K *

Partner with us to optimize and scale our Ruby on Rails applications, ensuring high availability and performance. Leverage your expertise in cloud infrastructure and Site Reliability Engineering to dr...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Shape the future of AI solutions on the ServiceNow platform by leading a team of experts in architecting, designing, and deploying innovative agentic capabilities. Drive impactful outcomes through int...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Staffing

$77K - $101K *

Elevate product operations by ensuring seamless releases and effective communication across teams. Collaborate with support, sales, and marketing to streamline processes, enhance documentation, and dr...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$145K - $175K *

Transform security in Windows by owning kernel-mode enforcement. Spearhead the development of critical components that determine access decisions in real-time, ensuring safe operations across various...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$205K - $240K *

Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Accelerate your career by driving analytics and operational excellence in a dynamic commercial environment. This role empowers you to enhance reporting, support strategic decisions, and collaborate cr...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$116K - $170K *

Champion electrical engineering excellence by leading installation standards, ensuring compliance, and driving continuous improvement in warehouse systems. Collaborate with cross-functional teams to e...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$114K - $218K *

Transform digital claims experiences by leading product strategy and execution. Collaborate with cross-functional teams to enhance user journeys, optimize performance, and drive innovation in technolo...

Today

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $225K *

Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$61K - $129K *

Engage your expertise to create and edit diverse technical documents, ensuring accuracy and clarity through collaboration with stakeholders. Play a pivotal role in producing high-quality content while...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Join a team that's driving off-page SEO and digital PR to elevate brand authority. You'll manage link building, engage with developer communities, and ensure our solutions are cited by AI platforms, a...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Transportation

$294K - $367K *

Lead the charge in shaping global tax strategy, ensuring compliance and governance while driving international expansion and sustainable growth. Collaborate with senior leadership to translate complex...

United StatesRemote

Today

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$134K - $201K *

Drive sales growth by managing specialty sales activities, developing strategic plans, and fostering high-level clinical relationships. Collaborate with teams to enhance customer engagement and ensure...

Today

  •   5 - 7 years exp.  •   Healthcare

$134K - $201K *

Lead the development and execution of specialty sales strategies, expanding customer relationships and driving growth. Collaborate with clinical teams to enhance training programs and ensure effective...

Today

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Join a team that's shaping the future of data services by designing and implementing robust integration solutions. Leverage your expertise in Ruby on Rails and REST APIs to drive innovative projects a...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$79K - $133K *

Elevate progress at the forefront of ArcGIS Hub by transforming customer workflows, communicating priorities, and enhancing geospatial collaboration through innovative product management...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.