Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Average Salary: $116,335
Staff Security Engineer - Calix Cloud
$136K - $265K *
Unlock potential by designing and securing advanced trust architectures across devices and cloud platforms. Collaborate with engineering teams to enhance security measures, conduct threat modeling, an...
Today
$80K - $95K *
Join a dynamic team to enhance automation systems, troubleshoot PLCs, and lead modernization projects. Supervise production staff while driving equipment reliability and process improvements in a fast...
Today
Senior Product Manager, Core (USA/Europe - Remote)
$170K - $207K *
Join a dynamic team to drive product vision and strategy for innovative solutions in the short-term rental market. Collaborate across departments to enhance customer experience and deliver impactful f...
Reposted today
Supplier Quality Engineer- Mechanical
$95K - $115K *
Shape the future of supplier quality in mechanical engineering by overseeing the quality assurance of critical components and systems. Collaborate with suppliers to ensure compliance, execute testing...
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Supplier Quality Engineer- Mechanical
$80K - $95K *
Take ownership of supplier quality for mechanical components, ensuring compliance from qualification through Factory Acceptance Testing. Collaborate with suppliers to uphold standards, manage inspecti...
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IT Info Security Analyst III - 992398 **Internal to Department Only **
$88K - $105K *
Drive risk assessments and vulnerability testing to enhance application security. Collaborate with IT teams to implement security solutions, prepare reports, and ensure compliance with regulations whi...
Today
$135K - $160K *
Transform your career by leading global product development initiatives, enhancing quality and compliance while driving innovation and operational efficiency across cross-functional teams...
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$90K - $147K *
Transform pediatric care by specializing in weight management and collaborating with endocrinologists. Engage in teaching while providing comprehensive medical support to young patients in a dynamic...
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$101K - $126K *
Join our team as a Lead System Administrator, overseeing global IT systems infrastructure. You'll ensure data integrity, manage a diverse team, and implement compliance frameworks while driving operat...
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Senior Platform Engineer (Infrastructure)
$120K - $145K *
Partner with us to optimize and scale our Ruby on Rails applications, ensuring high availability and performance. Leverage your expertise in cloud infrastructure and Site Reliability Engineering to dr...
Today
ServiceNow/AI Principal Technical Consultants- Remote/25% Travel
$150K - $180K *
Shape the future of AI solutions on the ServiceNow platform by leading a team of experts in architecting, designing, and deploying innovative agentic capabilities. Drive impactful outcomes through int...
Today
$77K - $101K *
Elevate product operations by ensuring seamless releases and effective communication across teams. Collaborate with support, sales, and marketing to streamline processes, enhance documentation, and dr...
Reposted today
Staff Software Development Engineer - Windows Endpoint
$145K - $175K *
Transform security in Windows by owning kernel-mode enforcement. Spearhead the development of critical components that determine access decisions in real-time, ensuring safe operations across various...
Reposted today
$205K - $240K *
Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...
Reposted today
Manager, Commercial Analytics & Operations
$110K - $130K *
Accelerate your career by driving analytics and operational excellence in a dynamic commercial environment. This role empowers you to enhance reporting, support strategic decisions, and collaborate cr...
Today
Senior Electrical Engineer, Installation
$116K - $170K *
Champion electrical engineering excellence by leading installation standards, ensuring compliance, and driving continuous improvement in warehouse systems. Collaborate with cross-functional teams to e...
Today
Digital Technical Product Manager Senior - Digital Claims
$114K - $218K *
Transform digital claims experiences by leading product strategy and execution. Collaborate with cross-functional teams to enhance user journeys, optimize performance, and drive innovation in technolo...
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Senior Machine Learning (ML) Engineer (CCC Casualty / Claims Intelligence)
$180K - $225K *
Join a team that's redefining AI in auto claims by building and evaluating machine learning models. You'll drive product decisions through data insights, collaborating with experts to enhance claims p...
Today
$61K - $129K *
Engage your expertise to create and edit diverse technical documents, ensuring accuracy and clarity through collaboration with stakeholders. Play a pivotal role in producing high-quality content while...
Reposted today
$95K - $115K *
Join a team that's driving off-page SEO and digital PR to elevate brand authority. You'll manage link building, engage with developer communities, and ensure our solutions are cited by AI platforms, a...
Today
$294K - $367K *
Lead the charge in shaping global tax strategy, ensuring compliance and governance while driving international expansion and sustainable growth. Collaborate with senior leadership to translate complex...
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Surgical Solutions Sales Manager
$134K - $201K *
Drive sales growth by managing specialty sales activities, developing strategic plans, and fostering high-level clinical relationships. Collaborate with teams to enhance customer engagement and ensure...
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Surgical Solutions Sales Manager
$134K - $201K *
Lead the development and execution of specialty sales strategies, expanding customer relationships and driving growth. Collaborate with clinical teams to enhance training programs and ensure effective...
Today
$130K - $155K *
Join a team that's shaping the future of data services by designing and implementing robust integration solutions. Leverage your expertise in Ruby on Rails and REST APIs to drive innovative projects a...
Reposted today
Product Engineer II - Web Services
$79K - $133K *
Elevate progress at the forefront of ArcGIS Hub by transforming customer workflows, communicating priorities, and enhancing geospatial collaboration through innovative product management...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.