Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,888

Sort By: Relevance

$125K - $187K *

Unlock potential by driving AI/ML innovations, collaborating with cross-functional teams to design and implement advanced machine learning models and solutions that enhance enterprise AI capabilities...

3 days ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$36K - $128K *

Elevate logistics operations by managing inventory, shipping, and cross-functional support. Drive process improvements and ensure accurate material handling while collaborating effectively across team...

3 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$135K - $173K *

Drive patient care excellence by joining our interdisciplinary team as a Physician Assistant in Endocrinology. You'll manage a diverse panel of patients, ensuring effective treatment and support while...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$79K - $115K *

Design and develop engaging instructional materials and programs, leveraging adult learning principles and technology to create impactful training experiences for diverse audiences in a hybrid work en...

3 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$111K - $161K *

Shape the future of home care leadership by guiding clinical teams, enhancing patient outcomes, and ensuring high-quality care delivery. Leverage your nursing expertise to oversee admissions and foste...

3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$230K - $260K *

Lead the charge in transforming master data management by defining strategy, enhancing party data, and driving adoption across global teams to support critical business functions and ensure data quali...

3 days ago

  •   11 - 15 years exp.  •   Finance & Insurance

$127K - $236K *

Lead the charge in transforming the New Business & Underwriting platform to enhance efficiency, compliance, and scalability, while partnering with diverse teams to deliver innovative solutions and mea...

Reposted 3 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$120K - $160K *

Join a team to lead commissioning projects, providing technical expertise and project management for critical facilities. Collaborate across teams, mentor others, and ensure successful testing and val...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Technical Services

$74K - $104K *

Manage comprehensive nursing care for students, collaborating with healthcare professionals to ensure effective health assessments, planning, and monitoring tailored to individual needs in a supportiv...

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$385K - $400K *

Transform regional sales performance by leading a high-impact team, driving strategic growth, and utilizing best practices to meet ambitious quotas within a dynamic environment. Foster relationships a...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$212K - $287K *

Transform the Hematology landscape by leading a high-performing sales team, driving strategic initiatives, and ensuring compliance while exceeding sales objectives in the Great Plains region...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead exceptional emergency care in a supportive environment, collaborating with a skilled team to manage urgent and critical cases. Enjoy a well-equipped facility designed for efficiency and high-qual...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Elevate behavioral health outcomes by designing and overseeing ABA programs. Collaborate with RBTs and caregivers, conduct assessments, and mentor future BCBAs while ensuring effective implementation...

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$77K - $123K *

Lead client relationships and enhance benefit strategies by advising on health plans, negotiating with carriers, and ensuring compliance. Drive impactful solutions while mentoring junior team members...

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$184K - $356K *

Drive technical engagement with telecom accounts, connecting customer workloads to NVIDIA's ecosystem. Serve as a trusted advisor, co-design scalable architectures, and lead technical enablement to en...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$145K - $170K *

Join us to drive strategic sales initiatives, leveraging a robust resource model and tech stack to achieve performance goals and maximize customer value in a dynamic, collaborative environment...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $90K *

Transform the claims landscape by managing commercial property claims, collaborating with diverse teams, and enhancing your expertise in global and excess lines. Join a dynamic environment focused on...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Empower the CDL program by leading training initiatives, ensuring compliance, and optimizing fleet management. Collaborate with regional leaders to enhance operational efficiency and drive revenue gro...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$124K - $158K *

Support patient care by leading pharmacy operations, ensuring safety, compliance, and quality. Collaborate with staff to enhance service delivery and drive growth while fostering a compassionate envir...

3 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $170K *

Champion the future of eDiscovery by leading project management and execution, ensuring effective data handling for litigation and regulatory matters while mentoring a dynamic team and enhancing clien...

3 days ago

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Lead the charge in developing and executing CMC strategies for antibody-based radiopharmaceuticals, ensuring alignment with Stage-Gate requirements while managing cross-functional teams and external p...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $135K *

Shape impactful training programs for Field Access teams, enhancing access and reimbursement capabilities across therapeutic areas. Collaborate with stakeholders to ensure compliance and relevance, fo...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $189K *

Lead the charge in delivering exceptional pharmaceutical care by interpreting prescriptions, consulting with patients, and ensuring quality assurance. Collaborate with healthcare professionals to opti...

RemoteRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Empower developers by diagnosing and resolving complex technical issues related to APIs. Collaborate across teams, advocate for improvements, and enhance developer experiences in a fast-paced, innovat...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Information Technology

$195K - $325K *

Join a team that's shaping the future of AI in healthcare by leading multi-year strategies, resolving complex technical challenges, and influencing executive decisions across the organization to ensur...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.