Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,888

Sort By: Relevance

$165K - $200K *

Transform captive program management by driving portfolio growth, enhancing underwriting practices, and fostering strong partner relationships. Join a dynamic team to shape innovative solutions and de...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$94K - $102K *

Drive your career with a hands-on role coordinating customer security and AI assessments. Collaborate across teams to streamline processes, enhance communication, and ensure timely responses, enabling...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$167K - $372K *

Drive growth by building and scaling a private equity partnerships program, enhancing existing relationships, and creating commercial opportunities through strategic engagement and collaboration with...

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$88K - $105K *

Lead the automation of invoice processes, optimizing Accounts Payable operations while driving strategic initiatives. Collaborate across departments to enhance efficiency and support a high-performing...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Media

$133K - $161K *

Transform your career by overseeing inpatient clinical operations, driving strategic initiatives, and enhancing resource utilization across multiple hospitals. Collaborate with leadership to ensure op...

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$90K - $130K *

Advance system integration testing by developing and managing HIL/SIL environments, ensuring compliance with quality standards, and collaborating with cross-functional teams to enhance product reliabi...

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$180K - $235K *

Lead the transformation of research models into deployable inference services, optimizing machine learning pipelines for large-scale image processing. Collaborate with cross-functional teams to enhanc...

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a pioneering team driving sales growth in the data center segment. You'll develop strategies, manage key accounts, and lead a virtual team to enhance customer satisfaction and deliver value in a...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$111K - $167K *

Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$124K - $158K *

Elevate patient care by supporting pharmacy operations across the district. As a key player, you'll ensure safe dispensing, manage pharmacy teams, and enhance patient experiences while embodying our v...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Champion the resolution of complex technical issues for clients, leveraging expertise in Linux, networking, and cloud environments. Collaborate with teams to enhance service delivery and operational c...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$104K - $144K *

Unlock potential by serving as a consultative wound care expert, educating clinicians, driving product adoption, and managing accounts to enhance patient healing and business growth in a dynamic healt...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$105K - $123K *

Unlock potential by supporting compliance risk management frameworks and processes. Engage with teams to enhance governance, reporting, and performance metrics, ensuring effective compliance and contr...

Yesterday

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Elevate our platform's infrastructure by designing, deploying, and maintaining robust cloud solutions. Ensure reliability and security while optimizing performance and costs, enabling our clients to t...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$254K - $305K *

Engage with us to design and evaluate vision models for in-cabin perception, enhancing rider safety and experience. Own model areas end-to-end, collaborating across teams to ensure reliable operations...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$190K - $316K *

Lead a high-performing platform engineering organization to deliver secure, reliable infrastructure services globally. Drive strategy, execution, and operational management across cloud, AI, and core...

RemoteRemote

Reposted yesterday

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Collaborate with clients to design, build, and integrate Power BI solutions, enhancing dashboard UI/UX and driving data insights through effective team engagement and innovative data modeling techniqu...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$112K - $189K *

Join us to ensure safe, effective medication therapy while advancing pharmaceutical care. Collaborate with healthcare teams, educate future practitioners, and support drug-related research to optimize...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Join a dynamic team to drive the development of a cutting-edge marketplace, enhancing provider products and economic incentives while collaborating closely with engineering and operations to transform...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$192K - $288K *

Join a team that's driving strategic initiatives in Neuroscience and Oncology. In this pivotal role, you'll partner with leadership to enhance operations, manage budgets, and streamline workforce plan...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$118K - $134K *

Unlock potential by driving innovative software solutions in a collaborative, fast-paced environment. Contribute to modernizing business applications while working closely with IT and business teams t...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $145K *

Unlock potential by bridging business needs with technical solutions. Collaborate with stakeholders to define requirements, manage product backlogs, and ensure successful delivery of ServiceNow capabi...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$78K - $122K *

Support executive leadership by managing complex schedules, communications, and operations. Foster organizational culture through strategic insights and proactive problem-solving, ensuring efficient w...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$230K - $345K *

Shape the future of late-stage oncology clinical trials by leading strategic initiatives, ensuring operational excellence, and fostering cross-functional partnerships to drive successful trial executi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.