Explore $100K+ Jobs in Massachusetts

Find professional opportunities in Massachusetts with salaries of $100,000 or more. From Boston and Cambridge to Worcester, Springfield, and other communities, the state offers a varied job market for experienced professionals seeking their next career move. Browse vetted listings on Ladders and explore roles aligned with your skills, experience, and compensation goals.

Discover Opportunities Across Massachusetts

Massachusetts is home to employers in industries including biotechnology, healthcare, finance, technology, higher education, consulting, and advanced manufacturing. Opportunities can range from specialized individual-contributor positions to director, vice president, and executive roles. Availability varies by employer and location, so review each listing for its requirements and work arrangement.

Find Roles That Match Your Experience

Use Ladders to explore high-paying professional jobs and focus your search by title, location, and area of expertise. Review responsibilities and qualifications carefully, then tailor your résumé to highlight relevant achievements, leadership experience, and measurable results.

Build Your Massachusetts Job Search

Whether you are targeting a role in Greater Boston or considering opportunities elsewhere in the state, a focused search can help you identify positions that fit your career priorities. Explore Massachusetts listings on Ladders to take the next step toward a role paying $100,000 or more.

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1,000+

Jobs in Massachusetts

Average Salary in USD

Average Salary: $125,888

Sort By: Relevance

$140K - $171K *

Join a team that's dedicated to enhancing client relationships in the mutual fund industry. Leverage your expertise to drive client satisfaction, manage complex accounts, and develop innovative soluti...

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$85K - $115K *

Elevate healthcare education by developing evidence-based content for clinicians. Collaborate with experts to create innovative learning materials that address practice gaps and enhance professional s...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$135K - $160K *

Lead a dynamic team to transform AI strategies into impactful healthcare solutions. Oversee engineering execution, guide architecture, and ensure compliance while collaborating with cross-functional p...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$228K - $342K *

Empower your career by leading strategic project management initiatives across early drug development. Drive process optimization, cultivate high-performing teams, and collaborate with executives to a...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $110K *

Advance your career by conducting vital physical security evaluations across multiple data centers. Collaborate with teams to enhance security measures and protect critical infrastructure while engagi...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$125K - $155K *

Manage security for offsite meetings and events across North America, ensuring compliance with policies and protocols. Lead security assessments, coordinate with stakeholders, and provide executive su...

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a team that's redefining product marketing by driving impactful go-to-market strategies, enabling sales teams, and translating complex product features into clear customer value across diverse ma...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$110K - $198K *

Advance automation solutions by designing and implementing manufacturing systems. Collaborate with cross-functional teams to enhance safety, quality, and productivity while managing multiple projects...

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$110K - $198K *

Transform your career by designing and implementing cutting-edge automation solutions that enhance manufacturing processes, improve safety, and drive productivity. Collaborate with cross-functional te...

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$77K - $107K *

Engage with students and faculty to advance Human Resources Management programs. Contribute to innovating curriculum, delivering exceptional teaching, and fostering industry ties while promoting an in...

Reposted yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$240K - $330K *

Join a team that’s pioneering growth in revenue intelligence by driving new business opportunities in financial services and healthcare. Leverage your extensive sales expertise to build relationships...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$98K - $157K *

Champion innovative immunology sales strategies to drive growth in the Gastroenterology sector. Engage healthcare professionals, influence decision-makers, and build lasting relationships to enhance p...

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$135K - $165K *

Innovate with cutting-edge data science techniques to develop algorithms and models that drive media planning decisions, collaborate with engineering, and deliver impactful insights to stakeholders...

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$172K - $216K *

Help us drive growth in the utilities sector by leading a high-performing sales team. You'll shape strategies, build relationships, and coach sellers to excel in complex, multi-year deals, ensuring al...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Consumer Technology

$120K - $180K *

Unlock potential by leading full-cycle sales in the corrections sector, driving innovative drone solutions. Collaborate with diverse teams to build trust and pipeline, while navigating complex agency...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$65K - $100K *

Lead the development and supervision of a high-performing team, ensuring compliance with company policies while fostering a culture of belonging and continuous improvement to meet business objectives...

Yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Champion innovative design solutions as a Principal Product Designer, leading UX strategy and AI experiences for a complex platform. Drive workflow transformation and mentor talent while shaping the f...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Consumer Technology

$75K - $90K *

Empower manufacturing excellence by evaluating processes, enhancing efficiency, and ensuring quality. Collaborate with teams to develop innovative solutions and support production goals while maintain...

Yesterday

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$79K - $112K *

Advance knowledge in behavioral neuroscience by establishing a funded research program, mentoring students, and collaborating within a vibrant academic community. Engage in innovative research and con...

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$105K - $191K *

Unlock your potential by leading advanced energy audits and driving impactful energy projects. Collaborate with cross-functional teams to enhance building efficiency and mentor the next generation of...

Yesterday

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$160K - $190K *

Lead the charge in managing U.S. Government contracts, guiding negotiations and compliance throughout the acquisition lifecycle. Collaborate with internal teams to ensure successful partnerships and m...

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$79K - $118K *

Elevate customer experiences by providing expert training and support for diabetes management technology. Collaborate cross-functionally to enhance product usage and ensure customer satisfaction throu...

Massachusetts, USRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$250K - $330K *

Drive strategic leadership and operational excellence in U.S. Medical Affairs for Prescription Dermatology, ensuring compliance and high-quality evidence generation while collaborating with cross-func...

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by driving pipeline visibility and forecasting accuracy. Collaborate with Sales, Marketing, and Finance to enhance workflows and insights, ensuring clean data and effective GTM strate...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$149K - $202K *

Transform the HCP launch landscape by leading innovative marketing initiatives for a groundbreaking treatment in Sjögren's disease. Collaborate cross-functionally to engage healthcare professionals an...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Massachusetts?question toggle

    Listings may include experienced professional, management, director, vice president, and executive roles across fields such as technology, healthcare, biotechnology, finance, education, and manufacturing. Specific openings and requirements vary.

  • Where in Massachusetts can I find high-paying jobs?question toggle

    Opportunities may be available in Boston, Cambridge, Worcester, Springfield, and other parts of the state. Browse current listings and check each posting for its location and work arrangement.

  • How can I search for Massachusetts jobs paying $100,000 or more?question toggle

    Browse Massachusetts listings on Ladders and refine your search by job title, location, and expertise. Review each posting's compensation information and qualifications.

  • Are Massachusetts jobs on Ladders vetted?question toggle

    Ladders hosts vetted professional job listings. Check the details of each listing to learn about the employer, role, location, compensation, and application requirements.