Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,152

Sort By: Relevance

$104K - $145K *

Elevate product development by defining, designing, and prototyping features for a merchant portal, leveraging AI tools and user feedback to enhance payment processing solutions rapidly and effectivel...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$89K - $134K *

Explore your potential as a key analytical consultant, leveraging data to optimize drug pricing and enhance pharmacy relationships while collaborating across multiple functions to drive strategic grow...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $165K *

Shape the future of AI platforms by leading strategy, architecture, and engineering for scalable, secure solutions. Drive innovation while ensuring compliance and operational excellence across enterpr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $192K *

Elevate your career by joining a dynamic team focused on driving demand in the Neurology Franchise. Collaborate with healthcare professionals and partners to achieve sales objectives and enhance patie...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$136K - $187K *

Lead patient education and support initiatives for individuals affected by generalized Myasthenia Gravis. Collaborate with caregivers and healthcare teams to enhance treatment coordination and empower...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$136K - $187K *

Join a team that's dedicated to empowering patients with generalized Myasthenia Gravis through education and support. As a key point of contact, you'll coordinate care, provide resources, and ensure c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$136K - $187K *

Unlock potential by serving as a vital resource for patients and caregivers, providing education and support for managing generalized Myasthenia Gravis while coordinating treatment and navigating insu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$168K - $231K *

Join a dynamic team to lead Nurse Case Managers, enhancing patient support and education throughout treatment journeys while ensuring compliance and quality in case management processes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$134K - $176K *

Lead the development and execution of a national supplier quality program, ensuring compliance and fostering strong supplier relationships to enhance operational efficiency and project success across...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$74K - $131K *

Empower recruitment excellence by leading strategic campaigns nationwide, building strong partnerships, and enhancing team performance. Drive impactful initiatives while adapting to diverse recruitmen...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Drive impactful analytics by designing and maintaining Power BI dashboards, leveraging SQL expertise to extract insights from complex datasets, and applying insurance knowledge to enhance reporting so...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$120K - $145K *

Drive the design and implementation of innovative pricing tools, enhancing market readiness and efficiency. Collaborate across teams to establish technical standards and mentor junior developers while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$98K - $112K *

Join a dedicated team providing compassionate hospice care across multiple locations. Collaborate with interdisciplinary teams to ensure quality patient outcomes while adapting to diverse clinical env...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$135K - $216K *

Advance the deployment of MHS GENESIS across multiple sites, ensuring seamless integration and performance outcomes while managing stakeholder relationships and project deliverables throughout the lif...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$135K - $216K *

Lead the charge in integrating DOD MP-ICAM solutions, focusing on CAC/PIV, SAML, and Active Directory. Collaborate with cybersecurity teams to enhance identity controls and support privileged-access w...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$112K - $179K *

Architect the migration of legacy health data into MHS GENESIS, leading a team to ensure seamless integration and data quality. Collaborate with stakeholders to define architecture and standards, driv...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$135K - $155K *

Drive impactful data solutions by bridging business needs with engineering teams. Own project intake, prioritize requests, and ensure clear communication across departments to enhance efficiency and d...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$115K - $120K *

Elevate software quality by managing test planning, execution, and reporting. Collaborate with development teams, mentor junior testers, and ensure compliance with cybersecurity standards while drivin...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $135K *

Join a dynamic team to oversee tax engagements, manage client relationships, and mentor junior staff. Utilize your expertise in tax planning and compliance while contributing to various consulting pro...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$175K - $200K *

Transform global talent acquisition by leading a multi-country team, setting strategic vision, and optimizing recruitment processes to meet business growth while ensuring compliance and enhancing cand...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Staffing

$125K - $133K *

Champion the development of Generative AI solutions, leading an agile team to enhance products and tooling. Drive AI adoption, mentor engineers, and ensure best practices while collaborating across de...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$108K - $115K *

Unlock your potential as a full stack engineer, collaborating in an agile team to develop innovative applications and features, while leveraging cutting-edge AI technologies to enhance product offerin...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Transform your career by guiding strategic growth through identifying and capturing high-value opportunities in the Federal market. Leverage relationships and insights to execute comprehensive capture...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$120K - $180K *

Drive the modernization of Veterans Benefits Administration claims processing by designing and optimizing scalable data pipelines and solutions, ensuring efficient data integration and analytics for i...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$102K - $174K *

Engage with us to lead Agile delivery across multiple Scrum teams, enhancing collaboration and efficiency. Drive continuous improvement, facilitate key ceremonies, and ensure alignment with project go...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.