Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,183

Sort By: Relevance

$120K - $145K *

Lead the charge in defining and activating brand strategies across multiple channels, enhancing donor engagement and retention through innovative content and social communications while collaborating...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$106K - $160K *

Lead complex contract negotiations and drive strategic supplier relationships. Collaborate with stakeholders to assess risks, develop negotiation strategies, and enhance contracting practices while me...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$95K - $115K *

Join our team to enhance clinical systems for medication management, focusing on optimizing workflows and supporting pharmacy operations. Collaborate with stakeholders to ensure accuracy and efficienc...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$114K - $252K *

Unlock potential by leading software development initiatives, ensuring system integration, and guiding teams through agile methodologies to deliver high-quality solutions that meet customer requiremen...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$118K - $180K *

Join a dynamic team enhancing nuclear power plants through advanced engineering. Leverage your expertise in thermodynamics and fluid mechanics to drive power uprate projects, mentor junior staff, and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$100K - $152K *

Empower progress in environmental compliance by developing air permitting strategies for complex industrial projects. Collaborate with multi-disciplined teams to ensure adherence to air quality regula...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$145K - $222K *

Lead a structural engineering team, guiding projects for nuclear facilities. Utilize your expertise in design and analysis while collaborating with clients and multidisciplinary teams to deliver innov...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$132K - $174K *

Shape the future of environmental consulting by leading complex projects, fostering client relationships, and driving strategic initiatives. Collaborate with multidisciplinary teams to ensure excellen...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Energy & Utilities

$110K - $130K *

Elevate product execution by translating client needs into actionable requirements, collaborating with engineering and data science teams to deliver standardized measurement solutions across various c...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$89K - $113K *

Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$75K - $104K *

Advance your career by leading maintenance operations to enhance manufacturing efficiency. Supervise a skilled team, drive continuous improvement, and ensure compliance with safety standards while col...

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$125K - $150K *

Shape the future of product marketing by bridging product and go-to-market teams. Drive impactful messaging, enablement, and strategies that resonate with audiences, ensuring alignment in a fast-paced...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$115K - $150K *

Architect and streamline cloud network infrastructure. Support robust security and connectivity across Azure, OpenShift, and SASE platforms. Collaborate with cross-functional teams, ensuring optimal p...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $100K *

Inspire community connections by engaging with prospective customers to promote high-speed telecommunication solutions. Drive sales growth through personalized consultations and compelling proposals w...

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$106K - $159K *

Unlock potential by leading integration initiatives and providing expert guidance within a dynamic team, ensuring effective business solutions and improved service delivery for a portfolio of global c...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $158K *

Join a dedicated team to lead the software development efforts for private brand growth. Empower engineers to create innovative solutions while overseeing project delivery and fostering a collaborativ...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Join a team that's leading complex high-value capital projects, from major renovations to design-build construction. Take ownership of multi-site projects, driving strategic planning and execution whi...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Transform the future of construction by leading high-value capital projects, from major renovations to design-build initiatives, while collaborating with stakeholders and driving project success acros...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$142K - $178K *

Lead the charge in strategic financial planning, driving insights and forecasts that shape growth. Collaborate with executives and teams to enhance financial models and reporting processes in a dynami...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Join a dynamic finance team as you oversee financial reporting, manage reconciliations, and enhance accounting processes. Your expertise will ensure compliance with GAAP while supporting audits and op...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $205K *

Champion innovative Salesforce solutions by leading architecture and integration efforts. Collaborate with stakeholders to enhance CRM capabilities, ensuring secure and efficient digital services whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Transform the security landscape by integrating security practices into CI/CD pipelines and Kubernetes environments, ensuring robust protection for cloud-native applications, AI services, and infrastr...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Drive sales success by building client relationships, analyzing market trends, and leading a dynamic sales team to achieve revenue goals while ensuring alignment with hotel strategies and maximizing b...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$200K - $500K *

Oversee project coordination and delivery timelines, bridging technical expertise with leadership to ensure efficient collaboration and successful execution of key initiatives within a dynamic develop...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.