Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,183

Sort By: Relevance

$176K - $294K *

Shape the future of oncology care by building strategic partnerships with key accounts, driving quality initiatives, and collaborating with cross-functional teams to enhance patient outcomes and align...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$108K - $250K *

Champion the promotion of innovative oncology solutions, enhancing patient care through strategic partnerships with healthcare providers and key opinion leaders, while driving brand growth and deliver...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$131K - $200K *

Join a team that's shaping the future of data platforms by developing scalable solutions for analytics and AI workloads. Collaborate on impactful projects using cutting-edge tools to enhance data reli...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $115K *

Grow your career with a dynamic team focused on optimizing provider operations. Lead credentialing initiatives, implement AI solutions, and enhance workflows while ensuring compliance and operational...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $105K *

Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Shape the future of brand strategy by crafting distinct messaging and positioning for a diverse portfolio of university partners. Collaborate with cross-functional teams to optimize campaigns and enha...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $150K *

Lead the charge in transforming healthcare systems through data-driven insights and collaborative engagement. Drive performance improvement by managing analytics projects, delivering client solutions...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Advance your career by driving impactful Paid Social strategies across platforms like Meta and TikTok. Collaborate with cross-functional teams to optimize campaigns, leverage data insights, and enhanc...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$202K - $250K *

Champion data-driven decision-making by leading the development of integrated analytics and reporting strategies. Drive operational efficiency and financial performance through innovative data solutio...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$105K - $120K *

Join a dynamic team to lead and enhance information security programs, ensuring compliance and risk management across diverse industries. Collaborate with executives to develop strategies that protect...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$160K - $185K *

Lead the charge in developing compelling proposals for government contracts, managing the entire proposal process from strategy to submission. Collaborate with cross-functional teams to ensure complia...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Technical Services

$110K - $130K *

Take ownership of comprehensive cyber risk assessments across the enterprise, articulating risks in business terms to ensure informed decision-making by leadership and helping to strengthen the organi...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Technical Services

$95K - $115K *

Accelerate your career by configuring and optimizing Workday solutions. Collaborate across teams to enhance HR operations and user experience through innovative system solutions and maintain data inte...

RemoteRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$125K - $154K *

Shape the future of AI by driving platform adoption, enhancing builder experiences, and managing the release lifecycle. Collaborate across teams to ensure governance and compliance while delivering me...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $154K *

Shape the future of AI by owning the enterprise context layer that empowers global AI agents. Collaborate with cross-functional teams to ensure accurate, governed, and timely context for enhanced oper...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$78K - $113K *

Unlock potential by leading complex revenue cycle projects, providing analytical support, and collaborating across departments to enhance billing processes and resolve financial issues in a fast-paced...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in driving OEM growth strategies, managing complex opportunities, and influencing cross-functional teams to deliver scalable solutions. Shape account strategies and enhance pipeline qu...

6 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$110K *

Champion the clinical operations team, ensuring project success through resource management, process efficiencies, and compliance. Drive training, metrics development, and mentorship to enhance team c...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $190K *

Unlock potential by serving as a functional SME in Workday solutions, advising and configuring systems to meet client needs. Balance multiple projects while ensuring timely issue resolution and delive...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Join our new Data Engineering team to lead business intelligence initiatives, build trusted data models in Snowflake, and deliver impactful reports in Power BI. Collaborate with stakeholders to enhanc...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Champion endpoint strategy and governance, leading a specialized team to deliver secure, scalable services across diverse devices. Collaborate with IT and business leaders to drive automation, operati...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$75K - $115K *

Innovate in cybersecurity as you drive technical conversations and deliver tailored solutions. Collaborate with sales teams to enhance customer relationships and showcase the unique value of next-gen...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $128K *

Unlock potential by driving cloud security sales initiatives, collaborating with teams, establishing partnerships with key personas, and engaging customers to integrate innovative security solutions i...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$77K - $118K *

Transform network operations by designing and implementing automation solutions that enhance reliability and efficiency across multi-vendor infrastructures, utilizing advanced technologies like Python...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.