Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,183

Sort By: Relevance

$110K - $130K *

Lead the charge in optimizing Agile practices for cross-functional teams, ensuring effective prioritization and communication. Protect team capacity while mentoring Scrum Masters to enhance execution...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $180K *

Elevate customer insights by translating data into actionable product capabilities. Collaborate with cross-functional teams to prioritize initiatives, enhance marketing performance, and leverage AI fo...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$168K - $240K *

Lead the charge in optimizing business operations through innovative solutions, driving efficiency and productivity while fostering cross-functional collaboration and data-driven decision-making to en...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Engineer robust security solutions by assessing web applications and APIs. Leverage your expertise in OWASP and SANS frameworks to identify vulnerabilities, conduct thorough testing, and enhance secur...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Unlock potential by partnering with ABA practice owners to enhance operations, drive growth, and improve performance. Collaborate closely with providers to navigate challenges and implement strategic...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$93K - $155K *

Drive strategic subcontract management and compliance, advising teams on Federal contract administration. Oversee complex subcontracts, ensuring alignment with regulations while enhancing revenue and...

6 days ago

  •   8 - 10 years exp.  •   Business Services

$85K - $105K *

Join us to analyze and adjudicate complex workers compensation claims, delivering innovative solutions in a dynamic environment. Collaborate with clients across industries while enjoying professional...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $180K *

Drive product strategy and execution for a critical portfolio area, leading cross-functional teams to transform user insights into impactful software solutions while mentoring others and shaping platf...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$110K - $130K *

Lead the charge in shaping product marketing strategies that drive adoption and pipeline. Collaborate with cross-functional teams to craft compelling narratives and ensure our differentiated value res...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$130K - $140K *

Elevate your career by joining a dynamic team to design and implement innovative cloud solutions in a multi-cloud environment, ensuring scalability, security, and alignment with business objectives wh...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$162K - $203K *

Champion scientific engagement by building relationships with key opinion leaders in Urology and Women's Health. Leverage expertise to support medical strategies and enhance product knowledge across t...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Elevate employee experiences by designing and implementing HR solutions. Lead technical projects, optimize integrations with Microsoft 365, and mentor developers to enhance ServiceNow capabilities and...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Champion the growth of our commercial engine by leading business development efforts, forging strategic partnerships, and driving revenue as quantum computing transitions to enterprise applications. C...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $185K *

Architect comprehensive clinical supply strategies for global trials. Collaborate across functional teams to secure timely, compliant drug supply while managing risks and inventory effectively, ensuri...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$115K - $140K *

Drive operational excellence in commercial readiness and support cross-functional teams to ensure effective execution of launch strategies and operational priorities in a dynamic biotech environment...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Optimize quality assurance processes to ensure compliance with regulatory standards and drive improvements across all operations. Lead a talented team to establish and maintain an effective Quality Ma...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$132K - $207K *

Elevate your career by driving growth in the mortgage industry, partnering with top lenders to enhance FICO's analytics solutions. Lead strategic initiatives, foster client relationships, and deliver...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$200K - $225K *

Transform marketing strategies to drive growth and engagement across public and private sectors. Lead integrated marketing efforts, brand positioning, and customer marketing services while leveraging...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$157K - $256K *

Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $180K *

Join a team that's dedicated to maintaining facilities efficiently and sustainably. Lead a skilled team, ensuring compliance and safety while enhancing the operational performance of buildings across...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$120K - $182K *

Accelerate growth by driving new software sales, building client relationships, and tailoring solutions to meet unique business needs. Collaborate with cross-functional teams to ensure a seamless cust...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$115K - $185K *

Elevate patient care as an Advanced Practice Provider in Trauma/Gen Surgery, managing critically ill adults in ICU and acute care settings. Collaborate with a multidisciplinary team to ensure quality...

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$85K - $105K *

Optimize regulatory compliance processes for a multi-state transportation network. Collaborate cross-functionally to ensure operational readiness and manage ongoing compliance across diverse markets...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$168K - $210K *

Transform pricing strategies by leading cross-functional teams to enhance decision-making and model deployment. Drive the evolution of pricing platforms, integrating advanced AI to streamline workflow...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $150K *

Elevate your career by driving enterprise sales for innovative solutions. Engage with multinational accounts, build strategic relationships, and lead complex negotiations to unlock growth opportunitie...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.