Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,152

Sort By: Relevance

$135K - $160K *

Lead the charge in developing and executing CMC strategies for antibody-based radiopharmaceuticals, ensuring alignment with Stage-Gate requirements while managing cross-functional teams and external p...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $135K *

Shape impactful training programs for Field Access teams, enhancing access and reimbursement capabilities across therapeutic areas. Collaborate with stakeholders to ensure compliance and relevance, fo...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $189K *

Lead the charge in delivering exceptional pharmaceutical care by interpreting prescriptions, consulting with patients, and ensuring quality assurance. Collaborate with healthcare professionals to opti...

RemoteRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $141K *

Champion quality improvement initiatives by developing practice changes, coordinating audits, and educating clinical teams. Engage with stakeholders and oversee clinical operations to enhance patient...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Empower developers by diagnosing and resolving complex technical issues related to APIs. Collaborate across teams, advocate for improvements, and enhance developer experiences in a fast-paced, innovat...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Information Technology

$195K - $325K *

Join a team that's shaping the future of AI in healthcare by leading multi-year strategies, resolving complex technical challenges, and influencing executive decisions across the organization to ensur...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Join a dynamic team to develop and enhance SaaS applications, utilizing Agile methodologies. Collaborate with peers, support customers, and drive innovative solutions while staying updated on technica...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$65K - $96K *

Advance leadership development by designing impactful programs and coaching talent. Collaborate with teams to enhance learning experiences and drive measurable success in succession planning and organ...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $135K *

Join a team that's shaping innovative experiential solutions while leading client services. Oversee project delivery from concept to execution, nurture client relationships, and scale talent in a dyna...

RemoteRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$110K - $196K *

Shape the future of K-12 education by leading product marketing strategies that drive growth and adoption. Collaborate cross-functionally to deliver compelling messaging and go-to-market initiatives t...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$75K - $86K *

Champion environmental initiatives by leading certification programs and technical reviews. Collaborate with stakeholders to enhance public health and environmental standards through education and com...

4 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Lead the charge in shaping a dynamic HR environment, fostering collaboration, and enhancing employee engagement while driving performance management and compliance across the organization...

4 days ago

  •   Less than 5 years exp.  •   Legal & Accounting

$95K - $115K *

Transform patient care delivery in radiation oncology by performing advanced assessments, managing comprehensive treatment plans, and collaborating with interdisciplinary teams to enhance patient outc...

Reposted 4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$170K - $210K *

Elevate project management excellence by leading design coordination for OFCI mechanical systems in a dynamic data center environment, ensuring seamless integration and adherence to technical standard...

United StatesRemote

4 days ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$116K - $165K *

Lead the design and integration of marine electrical systems for commercial and governmental vessels. Ensure compliance with regulatory standards while managing technical responsibilities for shipboar...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Advance your career by leading multi-team oversight and management in accounting operations across diverse industries. Utilize your expertise in compliance, software integration, and project managemen...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$88K - $105K *

Transform customer interactions by leading a diverse team to achieve performance goals. Drive operational strategies, foster an inclusive environment, and support leadership in decision-making to enha...

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$72K - $112K *

Serve as a vital link in healthcare by providing expert technical support for imaging equipment. You'll ensure optimal performance through installation, troubleshooting, and maintenance, while fosteri...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $123K *

Champion AI innovation by driving tool adoption, engineering practices, and workforce enablement across the enterprise. Collaborate with cross-functional teams, influencing leaders and building future...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Information Technology

$71K - $119K *

Drive customer success by leveraging expertise in intellectual property solutions, enhancing product adoption, and delivering exceptional experiences through strategic engagement and training initiati...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$85K - $100K *

Champion comprehensive psychiatric care for children, overseeing clinical services, program development, and staff training while ensuring quality standards and collaboration with healthcare professio...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Optimize strategic DeFi accounts by fostering relationships, driving adoption of services, and influencing product development through customer insights. Collaborate cross-functionally to ensure succe...

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$113K - $188K *

Contribute to innovative Salesforce solutions by leveraging your development expertise. Collaborate with cross-functional teams to design, build, and maintain scalable applications, ensuring high perf...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Business Services

$124K - $158K *

Lead the pharmacy team in delivering exceptional patient care, ensuring safe and accurate medication dispensing, and fostering a culture of excellence while complying with regulations and enhancing te...

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$74K - $124K *

Drive innovation by enhancing Power Platform tools for executive-level operations. Manage full lifecycle processes, ensuring compliance and improving operational efficiency through workflow automation...

United StatesRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.