Explore $100K+ Jobs in Kentucky

Find vetted professional opportunities paying $100,000 or more across Kentucky with Ladders. From Louisville and Lexington to growing communities throughout the state, explore roles for experienced professionals ready to take the next step in their careers. Browse openings across industries and compare opportunities that match your skills, experience, and goals.

Professional Opportunities Across Kentucky

Kentucky’s economy includes established sectors such as healthcare, manufacturing, logistics, finance, and technology, alongside growing businesses and regional employers. Opportunities vary by location and experience, with roles in corporate leadership, operations, sales, engineering, healthcare administration, and other professional fields. Review each listing for location, qualifications, compensation details, and work arrangement.

Find the Right Role for Your Experience

Use Ladders to focus your search on vetted jobs with salaries of at least $100,000. Explore positions by title, employer, location, or industry, and consider opportunities in major employment centers as well as other parts of Kentucky. Tailor your resume to each role and highlight measurable results, relevant expertise, and leadership experience.

Advance Your Career in Kentucky

Whether you are planning a career move within Kentucky or considering relocating to the state, compare openings and employer requirements to identify a strong fit. New listings and hiring needs can change, so check back regularly for current $100K+ professional opportunities.

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1,000+

Jobs in Kentucky

Average Salary in USD

Average Salary: $108,150

Sort By: Relevance

$110K - $130K *

Accelerate progress at the forefront of clinical research by ensuring effective oversight and management of clinical studies. Collaborate with teams to uphold quality standards and drive successful st...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Staffing

$95K - $115K *

Join a team that's dedicated to delivering high-quality, compassionate care in a dynamic Emergency Department. Lead nursing operations, enhance patient outcomes, and foster collaboration across discip...

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Partner with us to lead HR functions across a diverse workforce, driving talent development, operational excellence, and strategic initiatives while fostering a positive workplace culture and ensuring...

2 days ago

  •   5 - 7 years exp.  •   Food & Beverages

$92K - $166K *

Lead the planning and execution of digital transformation initiatives, ensuring alignment with strategic priorities. Collaborate with diverse teams to manage project scope, schedules, and deliverables...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$87K - $157K *

Shape the future of utility substations by leading physical design efforts, optimizing layouts, and collaborating across disciplines to deliver innovative engineering solutions for EPC projects...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$150K - $180K *

Advance offensive security research by designing red team agents and automating tradecraft. Shape full-chain operations across diverse environments, ensuring robust detection-evasion capabilities and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Technical Services

$175K - $210K *

Lead and grow a high-performing sales team, driving enterprise revenue and strategy in a dynamic market. Collaborate with partners and stakeholders to expand business while shaping product direction a...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $200K *

Help us drive revenue growth by activating strategic partnerships and channel relationships. This senior role focuses on maximizing sales potential across core product lines, ensuring effective collab...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$124K - $157K *

Join a team that's dedicated to transforming health care by delivering exceptional patient care, overseeing pharmacy operations, and fostering a culture of excellence. Your leadership will enhance tea...

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Transform your career by leading IT operations and team development, enhancing service delivery, and managing technology solutions for a dynamic workforce. Drive improvements and ensure seamless suppo...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $132K *

Join a team that's redefining network infrastructure for healthcare solutions. You'll design, implement, and support advanced wired and wireless networks, ensuring seamless connectivity and optimal pe...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $230K *

Drive strategic growth and innovation in AI-enabled assessment and workforce solutions. Lead high-impact projects, foster collaboration, and enhance AIR's national leadership in education and workforc...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$120K - $150K *

Unlock potential by leading software engineering initiatives, mentoring junior engineers, and driving improvements in development processes. Collaborate with stakeholders to deliver impactful solution...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Join a team that's redefining asset management through innovative Oracle ERP solutions. Lead enterprise-level systems engineering to enhance financial accuracy and streamline processes, ensuring compl...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$149K - $166K *

Lead the charge in advancing cutting-edge mechanical engineering solutions for high-performance electronics in space systems. Collaborate with cross-functional teams to deliver innovative designs that...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$157K - $174K *

Join a team that's shaping the future of combat vehicle software. Lead architectural design and technical direction for mission-critical systems, integrating advanced technologies in a collaborative...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$150K - $200K *

Drive strategic revenue growth by engaging C-suite stakeholders and closing multimillion-dollar partnerships within large pharmaceutical organizations. Leverage your expertise to navigate complex sale...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$166K - $200K *

Shape the future of healthcare technology by leading engineering for patient-centric systems. Drive innovation, ensure compliance, and mentor teams to deliver safe, efficient clinical solutions that e...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$90K - $110K *

Elevate your career by managing a diverse portfolio of retail and industrial properties across multiple states. This hands-on role focuses on operational excellence, financial performance, and tenant...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $140K *

Grow your career with a dynamic role in clinical support, training surgical teams, and ensuring optimal patient outcomes in complex procedures. Collaborate closely with medical professionals, manage i...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Engage in cutting-edge AI development by designing and scaling intelligent applications. Leverage Generative AI and modern tools to enhance productivity and integrate workflows within healthcare platf...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$155K - $200K *

Elevate product management by driving vision, strategy, and execution across digital solutions in clinical development. Collaborate with cross-functional teams to enhance user experience and operation...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Shape the future of client relationships in the metals industry by driving sales, managing key accounts, and ensuring customer satisfaction. Leverage market expertise to identify opportunities and fos...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$103K - $184K *

Transform compliance processes by leading IT SOX initiatives, ensuring robust internal controls and regulatory adherence across the organization while collaborating with cross-functional teams to miti...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Transportation

$90K - $150K *

Lead your career with a pivotal role in strategic sales, driving revenue through exceptional account management and cultivating strong relationships with agencies and clients to expand our innovative...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • Where can I find jobs paying $100,000 or more in Kentucky?question toggle

    Browse Ladders for vetted professional openings in Kentucky with salaries of $100,000 or more. Search by job title, employer, industry, or location to narrow your options.

  • What types of high-paying professional jobs are available in Kentucky?question toggle

    Opportunities may include leadership, healthcare administration, manufacturing, logistics, finance, technology, sales, and engineering roles. Availability and qualifications vary by employer and location.

  • Which Kentucky cities have professional job opportunities?question toggle

    Louisville and Lexington are major employment centers, and professional openings may also be available in other Kentucky communities. Check individual listings for the job location and work arrangement.

  • How can I improve my chances of getting a $100K+ job in Kentucky?question toggle

    Target roles that closely match your experience, tailor your resume to the job requirements, and emphasize measurable achievements, specialized expertise, and leadership impact.

  • Are all jobs listed in Kentucky remote or hybrid?question toggle

    Work arrangements vary by position and employer. Review each listing to see whether the role is onsite, hybrid, or remote.