Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,016

Sort By: Relevance

$171K - $231K *

Inspire strategic leadership in global clinical operations, driving program success through effective management, mentorship, and cross-functional collaboration to enhance patient access to innovative...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$108K - $130K *

The FRCS Cybersecurity Manager is responsible for the installation, configuration, and maintenance of IT and OT systems related to Facility-Related Control Systems. This role involves ensuring complia...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Technical Services

$90K - $120K *

Oversee comprehensive social compliance audits, ensuring adherence to CSCA standards while managing audit teams and providing certification recommendations based on thorough analysis and collaboration...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$125K - $150K *

Shape the future of employee engagement by leading initiatives that enhance organizational capabilities and drive a culture of ownership, collaboration, and continuous improvement across the enterpris...

Reposted yesterday

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$151K - $205K *

Engineer innovative biostatistical programming solutions, leading cross-functional teams to ensure timely delivery of clinical data analysis and compliance. Drive operational excellence in biosimilar...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$75K - $101K *

Transform the future of global development operations by supporting strategic planning, enhancing business processes, and ensuring compliance. Collaborate with diverse teams to drive project success a...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$200K - $300K *

Champion strategic bank capital relationships, driving coverage and capital formation across diverse financial products. Collaborate with teams to enhance bank participation and manage relationships...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$105K - $115K *

Join a team that's focused on diversifying paid media channels and optimizing conversion strategies. You'll lead initiatives across affiliate, programmatic, and social platforms to enhance member acqu...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$90K - $120K *

Strategize as a key HR partner, aligning people strategies with business goals, navigating complex employee relations, and driving continuous improvement across HR functions in a remote role focused o...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $160K *

Partner with us to drive organizational effectiveness as a strategic Chief of Staff. Lead executive operations, enhance team cohesion, and manage internal communications while supporting the Executive...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $170K *

Transform financial processes and drive insights for the Brita Business Unit. Collaborate with cross-functional teams to enhance accuracy in forecasting and reporting while identifying opportunities f...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Food & Beverages

$150K - $180K *

Pioneer strategic leadership in Multi-Party Project Coordination & Liability Management, driving business growth, client relationships, and team development while overseeing complex environmental prog...

United StatesRemote

Reposted yesterday

  •   15+ years exp.  •   Technical Services

$140K - $180K *

Deliver cutting-edge engineering solutions by designing and analyzing power plant systems, enhancing both new and existing facilities while collaborating across teams to solve critical engineering cha...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $120K *

Elevate your career by managing regional service operations, ensuring exceptional customer relations, and leading a high-performance team. Drive strategic initiatives, optimize service delivery, and f...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$104K - $143K *

Join a team that's driving strategic cybersecurity initiatives to enhance security posture, reduce risk, and achieve compliance. Collaborate across technical and business domains to ensure successful...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$104K - $143K *

Join a dynamic team to evaluate clinical program performance using advanced statistical and epidemiologic methods. Drive impactful analyses that inform strategic decisions and enhance healthcare outco...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$129K - $177K *

Discover a dynamic role analyzing financial data to guide strategic decisions. Collaborate with stakeholders, develop metrics, and ensure data integrity while advising executives on key insights to en...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$121K - $155K *

Invent compelling narratives and lead creative development across multiple brands. Collaborate with teams to ensure strategic alignment, mentor junior staff, and engage clients effectively to elevate...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Empower your career by leading complex data center scheduling projects. Collaborate with innovative teams to create precise construction schedules, manage risks, and drive impactful results in a dynam...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$239K - $336K *

Empower progress in oncology research by leveraging your clinical expertise and data-driven insights. Collaborate with a diverse team to enhance real-world evidence applications, driving innovation in...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$122K - $183K *

Champion the management of Cyber and Technology claims, overseeing investigations, litigation, and resolution strategies to ensure optimal outcomes while collaborating with stakeholders and enhancing...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$114K - $183K *

Join a team that's driving strategic sourcing and supplier management for capital equipment investments. Lead cross-functional initiatives to optimize costs, enhance supplier relationships, and suppor...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$110K - $130K *

Reimagine space management and GIS solutions, driving innovation in product strategy and execution. Collaborate with universities to enhance workflows, optimize features, and deliver impactful results...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$184K - $220K *

Take ownership of a dynamic Solutions Architects team, driving successful client outcomes through innovative observability solutions. Collaborate across departments to enhance Grafana technologies and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$90K - $110K *

Engage clients by leading the technical onboarding of a digital banking platform. Collaborate with internal teams to customize features, support data conversion, and ensure timely, high-quality deploy...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.