Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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1,000+

Jobs in Iowa

Average Salary in USD

Average Salary: $110,016

Sort By: Relevance

$100K - $120K *

Join a team that's focused on driving partner growth in the travel industry. Leverage your expertise to build relationships, implement strategic plans, and engage clients, all while thriving in a coll...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$78K - $128K *

Lead the product lifecycle for health plans, driving strategy, development, and market alignment. Collaborate with cross-functional teams to enhance offerings and ensure compliance, while identifying...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$88K - $105K *

Drive operational excellence by owning the Professional Services intake and workflow governance processes, ensuring efficient request management and seamless team collaboration to enhance service deli...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$131K - $237K *

Unlock potential by driving business growth in the cruise missile sector, engaging with U.S. Navy and Marine Corps stakeholders to identify and capture new opportunities while collaborating with cross...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$185K - $344K *

Join a dynamic team driving strategic planning and performance management across analytics capabilities. Lead portfolio governance and execution initiatives to align resources and priorities, ensuring...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $113K *

Lead strategic initiatives to enhance advocacy for California's children and youth. Collaborate with stakeholders, manage programs, and drive fundraising efforts to ensure impactful policy changes and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $110K *

Drive end-to-end payroll processes across multiple entities, ensuring accuracy and compliance. Manage domestic and international payroll, tax setups, and employee inquiries while building scalable sys...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$86K - $165K *

Elevate your career by driving the development and integration of cutting-edge avionics systems. Leverage your expertise in systems engineering to optimize performance and ensure seamless communicatio...

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$122K - $270K *

Empower state and local governments by leading transformative Cloud ERP engagements. Drive functional design, change management, and integration strategies while fostering senior client relationships...

1 week ago

  •   5 - 7 years exp.  •   Business Services

$81K - $136K *

Join a team that's pioneering innovative radar and surveillance solutions. Lead proposal management and program execution, ensuring high-quality submissions while collaborating across functions to dri...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Lead the charge in managing a technical team focused on Gitaly, driving performance, scalability, and maintainability while fostering a culture of accountability and ownership across distributed teams...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$148K - $313K *

Unlock potential by serving as a strategic advisor to enterprise clients, guiding them in architecting AI-first solutions within the Life Sciences sector, while driving internal initiatives and enhanc...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Drive growth by building and expanding enterprise pipelines through strategic outbound efforts and executive networking. Collaborate cross-functionally to secure high-value deals and establish long-te...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Unlock potential by architecting innovative IT solutions that align with client goals. Collaborate with sales teams and engage directly with customers to deliver tailored strategies, ensuring successf...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$73K - $132K *

Join a dynamic team as a Senior Environmental Chemist, providing expert oversight in environmental data management and validation. Lead projects ensuring compliance and quality in remediation efforts...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Technical Services

$144K - $230K *

Engage with our sales team as a Technical Sales Lead, driving technology evaluations and managing customer relationships. Leverage your expertise in telecommunications to ensure satisfaction throughou...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$210K *

Empower patients through innovative telehealth solutions. Join our team of board-certified OB/GYN physicians to deliver high-quality, patient-centered care across Iowa, balancing flexibility with clin...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$210K *

Engage in a rewarding telehealth role, providing compassionate care across various clinical cases. Enjoy flexible scheduling while delivering high-quality virtual consultations to patients throughout...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $159K *

Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$152K - $283K *

Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$123K - $168K *

Engage with healthcare professionals to drive product growth and acceptance. Build lasting relationships, educate stakeholders, and collaborate cross-functionally to enhance market presence and uphold...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$155K - $258K *

Shape the future of AI in healthcare by leading architectural design and technical strategy for LLM-powered systems. Mentor engineers, ensure compliance, and drive innovation in a highly regulated env...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$105K - $120K *

Drive the substantiation of health claims for dietary supplements by reviewing scientific evidence and collaborating with cross-functional teams to ensure compliance with regulatory standards and enha...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$156K - $281K *

Drive innovative solutions by leading complex Federal acquisitions, guiding cross-functional teams, and delivering high-quality proposals. Leverage technical expertise to elevate win probability and e...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.