Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$100K - $150K *

Lead the charge in ERP implementation, guiding customer onboarding, deploying solutions, and driving alignment across teams to optimize finance transformations and enhance customer experiences in a dy...

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  •   Less than 5 years exp.  •   Enterprise Technology

$56K - $115K *

Join a dynamic team as a Site Contracts Specialist, where you will negotiate and manage clinical trial agreements. Lead contract discussions, mitigate risks, and collaborate with key stakeholders to e...

North Carolina, USRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$184K - $253K *

Drive strategic partnerships and technology transactions as a Senior Counsel, overseeing complex agreements and M&A support. Collaborate cross-functionally to build processes and provide business-focu...

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Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$110K - $130K *

Drive impactful solutions as you lead integration efforts, enhancing user experiences through collaboration and innovation while managing multiple complex projects and mentoring junior engineers...

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3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

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Calgary, ABRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$96K - $125K *

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4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$65K - $129K *

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Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$104K - $166K *

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2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$174K - $224K *

Empower organizations by shaping data governance strategies that enhance security, compliance, and operational resilience. Collaborate with cross-functional teams to deliver impactful governance solut...

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4 days ago

  •   8 - 10 years exp.  •   Information Technology

$111K - $206K *

Join a team that's driving mission success through innovative program planning. Collaborate across functions to develop and maintain schedules, ensuring on-time, in-budget delivery of complex projects...

Fort Worth, TXRemote

Yesterday

  •   8 - 10 years exp.  •   Aerospace & Defense

$88K - $150K *

Lead contract management initiatives by drafting, negotiating, and overseeing agreements while collaborating with cross-functional teams to enhance efficiency and support strategic legal operations in...

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Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Champion seamless data integration across IT systems by leading complex projects, troubleshooting issues, and optimizing performance. Leverage your expertise in integration technologies to ensure data...

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2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead complex integration projects, ensuring seamless data exchange across IT systems. Utilize your expertise in integration technologies to troubleshoot issues and optimize performance, while mentorin...

Englewood, CORemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$300K - $330K *

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1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $105K *

Analyze and enhance FOIA processes, ensuring compliance and efficiency. Collaborate with a team to evaluate requests, manage records, and implement necessary redactions while maintaining government st...

Mclean, VARemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$81K - $129K *

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Wilmington, DERemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$147K - $233K *

Lead the charge in executing complex government development programs that ensure reliable, secure, and resilient connectivity solutions across various domains, meeting critical mission objectives with...

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Reposted 3 days ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$110K - $130K *

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Ohio, USRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $175K *

Join a team that's dedicated to delivering high-quality medical writing. You'll lead the creation of essential documents for clinical studies, ensuring clarity and compliance with regulatory standards...

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3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $175K *

Lead the creation of high-quality medical writing deliverables, ensuring clarity and compliance with regulatory standards. Collaborate across departments to manage projects and mentor junior writers w...

Massachusetts, USRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $175K *

Transform the landscape of medical writing by leading deliverables, ensuring clarity and compliance with regulatory standards. Collaborate across departments to produce high-quality documents that dri...

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4 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

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2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $210K *

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Philadelphia, PARemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $210K *

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Boston, MARemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$195K - $220K *

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Arizona, USRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.