Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$83K - $114K *

Empower your career by leading diverse construction projects across the U.S. and overseas. Manage teams, ensure quality, and maintain safety standards while delivering mission-critical facilities on t...

Alexandria, VARemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$110K - $120K *

Explore a pivotal role in leading complex analysis across systems, driving alignment among stakeholders, and enhancing technology solutions. Collaborate with diverse teams to translate business needs...

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1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$78K - $98K *

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Pittsburgh, PARemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$65K - $130K *

Contribute to clinical trial success by leading risk management and central monitoring activities. Collaborate with cross-functional teams to ensure compliance with ICH GCP guidelines and enhance qual...

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Reposted yesterday

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Unlock potential by leading application security initiatives, enhancing product security, and driving secure development practices. Collaborate with engineering teams to establish standards, manage vu...

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3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$91K - $163K *

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3 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

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2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$100K - $120K *

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1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

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Reposted 1 month ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $192K *

Engineer trusted, reusable data products by transforming architectural designs and business requirements into production-grade solutions. Collaborate with cross-functional teams to deliver innovative...

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4 days ago

  •   5 - 7 years exp.  •   Healthcare

$146K - $203K *

Optimize enterprise-wide business continuity management by leading the development and implementation of a robust BCM framework, ensuring critical services are maintained and recovery capabilities are...

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2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Drive business growth by leading end-to-end capture efforts in cybersecurity and intelligence sectors. Engage customers, shape strategies, and close deals while owning the full lifecycle of opportunit...

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Yesterday

  •   8 - 10 years exp.  •   Information Technology

$140K - $190K *

Empower our Security & GRC initiatives by managing projects that ensure compliance, drive accountability, and foster collaboration across teams. Lead the project management framework to keep programs...

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$68K - $143K *

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Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$140K - $180K *

Champion security initiatives by embedding secure design principles across applications, cloud, and infrastructure. Collaborate with engineering teams to enhance security maturity and protect over 6,0...

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1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$131K - $178K *

Unlock your potential by leading a dynamic Agile team in developing enterprise applications. Leverage your AWS expertise and hands-on coding skills to drive innovation and mentor developers while ensu...

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6 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Shape the future of cloud operations by enhancing reliability and efficiency in production environments. Collaborate with teams to ensure robust monitoring, automate processes, and support critical sy...

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4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$95K - $115K *

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2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$143K - $244K *

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5 days ago

  •   8 - 10 years exp.  •   Business Services

$128K - $173K *

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1 week ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $200K *

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Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$104K - $166K *

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1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$92K - $138K *

Join us as a Clinical Application Specialist, leveraging your expertise in maternal-infant care to deliver training and support for digital healthcare solutions. Collaborate with teams to enhance clin...

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2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$80K - $89K *

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Reposted 1 week ago

  •   Less than 5 years exp.  •   Technical Services

$85K - $120K *

Shape the future of cybersecurity by analyzing North Korean threats and providing actionable intelligence. Collaborate with experts to uncover insights that drive strategic decisions and enhance secur...

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Yesterday

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.