Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$80K - $95K *
Champion efficiency in the revenue cycle as you lead a dedicated billing team. Drive performance improvements, oversee compliance, and identify revenue opportunities while cultivating a culture of exc...
Reposted 4 weeks ago
Business Analyst (NCPDP) - Remote
$95K - $115K *
Champion innovative solutions as a Business Solutions Analyst, collaborating with healthcare organizations to drive strategic initiatives and operational excellence across diverse projects and deliver...
4 weeks ago
RN - Full-time Days - SF Center
$70K - $99K *
Empower your career by delivering personalized nursing care in a top-rated facility. Utilize your expertise to collaborate with a dedicated team, ensuring excellence in resident care and rehabilitatio...
Reposted 4 weeks ago
$112K - $197K *
Lead the charge in delivering exceptional patient care by overseeing pharmacy operations, ensuring compliance, managing finances, and fostering community outreach while driving sales and developing te...
4 weeks ago
Complex Pediatric Clinical Psychologist
$80K - $95K *
Transform pediatric care by integrating psychological services within a dynamic, interdisciplinary team. Collaborate with healthcare professionals to support children and families, addressing emotiona...
4 weeks ago
Nurse Practitioner/Physician Assistant - Cardiology
$90K - $110K *
Elevate cardiovascular care by collaborating with healthcare teams to provide comprehensive assessments, treatment plans, and follow-up for patients in both outpatient and inpatient settings, ensuring...
4 weeks ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | Telehealth
$80K - $100K *
Join a team that's dedicated to delivering high-quality psychotherapy to older adults. Enjoy flexible scheduling, comprehensive support, and the opportunity to make a meaningful impact in a collaborat...
4 weeks ago
Manager, Market Access and Reimbursement - North Central
$136K - $170K *
Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...
4 weeks ago
$110K - $130K *
Transform early phase clinical trials by leading design, execution, and oversight. Collaborate with cross-functional teams to ensure compliance and data integrity while managing project performance an...
4 weeks ago
$90K - $110K *
Analyze clinical documentation and risk adjustment for healthcare providers, ensuring accurate representation of patient acuity. Collaborate with physicians to identify documentation opportunities and...
4 weeks ago
Associate Director, Central Monitoring
$164K - $247K *
Join a dynamic team to lead central monitoring efforts in clinical trials, driving data-driven insights and risk management strategies. Collaborate across functions to enhance monitoring efficiency an...
4 weeks ago
$90K - $95K *
Drive the successful adoption of advanced hearing solutions by providing expert clinical support and education to healthcare professionals. Collaborate closely with cross-functional teams to enhance p...
4 weeks ago
Senior Health Systems Specialist - Data & Analytics
$110K - $130K *
Advance analytics and informatics solutions by integrating VA databases, developing dashboards, and collaborating in Agile teams to enhance healthcare delivery for Veterans, ensuring effective data ma...
4 weeks ago
$80K - $95K *
Drive revenue cycle optimization by enhancing Epic Professional Billing workflows, collaborating with stakeholders, and resolving claims challenges to improve overall operational efficiency and ensure...
4 weeks ago
Remote Evening Radiologist - IC
$250K - $300K *
Oversee and deliver exceptional diagnostic imaging services remotely, focusing on evening shifts. Collaborate within a dynamic team while managing varied inpatient and outpatient cases to support pati...
4 weeks ago
Subject Matter Expert - Medicare Administrative Contractors (MACs)
$146K - $234K *
Lead critical CMS operations by providing expert guidance on Medicare Administrative Contractors, ensuring project teams leverage deep knowledge of MAC functions and regulations to enhance the Medicar...
4 weeks ago
Virtual Occupational Health Physical Therapist (Evaluation-Only)
$80K - $95K *
Join a team that's dedicated to transforming occupational health evaluations through virtual care. Utilize your expertise to assess diverse worker populations, direct care paths, and support workplace...
4 weeks ago
Clinical Pharmacist (Formulary & Quality)
$107K - $199K *
Redefine pharmacy care by developing formularies and policies, enhancing quality programs, and driving initiatives that improve Medicaid services while collaborating with diverse teams and stakeholder...
4 weeks ago
$85K - $130K *
Champion change in healthcare IT consulting by leading enterprise software projects and enhancing organizational workflows. Collaborate with leadership, drive client success, and deliver impactful res...
4 weeks ago
$100K - $120K *
Support clinical studies by assisting teams with tasks like medical monitoring and protocol management. Collaborate across functions and engage with stakeholders to ensure successful trial outcomes wh...
4 weeks ago
$120K - $162K *
Drive pharmacy operations as a licensed Pharmacist, ensuring compliance, safety, and exceptional customer care. Lead a dedicated team while managing workflow, performance metrics, and process improvem...
Reposted 4 weeks ago
$80K - $99K *
Help us elevate patient care as a Physical Therapist, treating diverse conditions while creating individualized plans. Experience mentorship and opportunities for professional growth in a collaborativ...
4 weeks ago
Remote Clinical Psychologist - Older Adults | PhD / PsyD | PSYPACT | Telehealth
$100K - $120K *
Join a team that's redefining telehealth by delivering exceptional psychotherapy to older adults. Enjoy flexible hours, comprehensive support, and opportunities for professional growth while making a...
4 weeks ago
Associate Director, Medical Affairs- Hematology (northern CA/Nevada)
$176K - $287K *
Lead the charge in advancing scientific discourse by engaging KOLs and HCPs in Hematological Malignancies. Drive strategic medical initiatives while fostering relationships to enhance research and cli...
4 weeks ago
$262K - $404K *
Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.