Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$80K - $95K *

Champion efficiency in the revenue cycle as you lead a dedicated billing team. Drive performance improvements, oversee compliance, and identify revenue opportunities while cultivating a culture of exc...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Champion innovative solutions as a Business Solutions Analyst, collaborating with healthcare organizations to drive strategic initiatives and operational excellence across diverse projects and deliver...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$70K - $99K *

Empower your career by delivering personalized nursing care in a top-rated facility. Utilize your expertise to collaborate with a dedicated team, ensuring excellence in resident care and rehabilitatio...

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $197K *

Lead the charge in delivering exceptional patient care by overseeing pharmacy operations, ensuring compliance, managing finances, and fostering community outreach while driving sales and developing te...

4 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $95K *

Transform pediatric care by integrating psychological services within a dynamic, interdisciplinary team. Collaborate with healthcare professionals to support children and families, addressing emotiona...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Elevate cardiovascular care by collaborating with healthcare teams to provide comprehensive assessments, treatment plans, and follow-up for patients in both outpatient and inpatient settings, ensuring...

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $100K *

Join a team that's dedicated to delivering high-quality psychotherapy to older adults. Enjoy flexible scheduling, comprehensive support, and the opportunity to make a meaningful impact in a collaborat...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$136K - $170K *

Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Transform early phase clinical trials by leading design, execution, and oversight. Collaborate with cross-functional teams to ensure compliance and data integrity while managing project performance an...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Analyze clinical documentation and risk adjustment for healthcare providers, ensuring accurate representation of patient acuity. Collaborate with physicians to identify documentation opportunities and...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$164K - $247K *

Join a dynamic team to lead central monitoring efforts in clinical trials, driving data-driven insights and risk management strategies. Collaborate across functions to enhance monitoring efficiency an...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $95K *

Drive the successful adoption of advanced hearing solutions by providing expert clinical support and education to healthcare professionals. Collaborate closely with cross-functional teams to enhance p...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Advance analytics and informatics solutions by integrating VA databases, developing dashboards, and collaborating in Agile teams to enhance healthcare delivery for Veterans, ensuring effective data ma...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Drive revenue cycle optimization by enhancing Epic Professional Billing workflows, collaborating with stakeholders, and resolving claims challenges to improve overall operational efficiency and ensure...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $300K *

Oversee and deliver exceptional diagnostic imaging services remotely, focusing on evening shifts. Collaborate within a dynamic team while managing varied inpatient and outpatient cases to support pati...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$146K - $234K *

Lead critical CMS operations by providing expert guidance on Medicare Administrative Contractors, ensuring project teams leverage deep knowledge of MAC functions and regulations to enhance the Medicar...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$80K - $95K *

Join a team that's dedicated to transforming occupational health evaluations through virtual care. Utilize your expertise to assess diverse worker populations, direct care paths, and support workplace...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$107K - $199K *

Redefine pharmacy care by developing formularies and policies, enhancing quality programs, and driving initiatives that improve Medicaid services while collaborating with diverse teams and stakeholder...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $130K *

Champion change in healthcare IT consulting by leading enterprise software projects and enhancing organizational workflows. Collaborate with leadership, drive client success, and deliver impactful res...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$100K - $120K *

Support clinical studies by assisting teams with tasks like medical monitoring and protocol management. Collaborate across functions and engage with stakeholders to ensure successful trial outcomes wh...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $162K *

Drive pharmacy operations as a licensed Pharmacist, ensuring compliance, safety, and exceptional customer care. Lead a dedicated team while managing workflow, performance metrics, and process improvem...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$80K - $99K *

Help us elevate patient care as a Physical Therapist, treating diverse conditions while creating individualized plans. Experience mentorship and opportunities for professional growth in a collaborativ...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a team that's redefining telehealth by delivering exceptional psychotherapy to older adults. Enjoy flexible hours, comprehensive support, and opportunities for professional growth while making a...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$176K - $287K *

Lead the charge in advancing scientific discourse by engaging KOLs and HCPs in Hematological Malignancies. Drive strategic medical initiatives while fostering relationships to enhance research and cli...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$262K - $404K *

Optimize patient care and operational leadership as you manage Anesthesia APP teams, ensure regulatory compliance, and build strong client relationships while driving growth in practices and enhancing...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.