Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$111K - $167K *
Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...
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Pharmacist, Home Infusion - Evernorth - Hybrid or Remote
$112K - $189K *
Join us to ensure safe, effective medication therapy while advancing pharmaceutical care. Collaborate with healthcare teams, educate future practitioners, and support drug-related research to optimize...
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Clinical Informatics & Ontology Lead
$120K - $145K *
Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...
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$72K - $104K *
Elevate nursing standards by supervising clinical staff, ensuring compliance with policies, and delivering quality patient care in a correctional environment. Collaborate with healthcare teams to enha...
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$110K - $130K *
Innovate data-driven product strategies by leading informatics initiatives, ensuring rigorous testing and quality assessments while collaborating across teams to enhance client services and streamline...
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$93K - $104K *
Join a team that's dedicated to providing exceptional patient care while enjoying flexible scheduling options. As a Registered Nurse, you'll play a vital role in assessing and supporting patients in v...
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$69K - $119K *
Transform the landscape of clinical documentation by educating and mentoring teams, ensuring compliance, and enhancing documentation accuracy to optimize patient care and coding outcomes...
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$82K - $132K *
Unlock potential in revenue cycle management by leading innovative solutions, optimizing processes, and collaborating across departments to enhance operational efficiency and maximize revenue impact...
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Director, Clinical Systems Operations (Pharmacy)
$134K - $249K *
Lead the charge in enhancing clinical systems operations, driving efficiency and effectiveness across pharmacy initiatives while managing a dedicated team and overseeing complex workflows and data int...
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$150K - $180K *
Drive strategic clinical operations and program development to enhance patient outcomes. Lead a multidisciplinary team, ensuring compliance and effective care coordination across acute and post-acute...
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Clinical Trial Manager/Senior Clinical Trial Manager
$110K - $200K *
Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...
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Licensed Practical Nurse (LPN)
$83K - $87K *
Deliver exceptional patient care by providing skilled nursing services in various settings. Collaborate with healthcare teams to enhance patient outcomes while enjoying flexible scheduling and competi...
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Director, Market Access - Commercial Coverage & Reimbursement
$187K - $281K *
Redefine market access strategies by leading payer engagement to enhance patient access to genomic testing. Collaborate cross-functionally to drive favorable coverage and reimbursement policies, ensur...
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Medical Director, Utilization Management
$180K - $220K *
Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...
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$160K - $200K *
Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...
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$93K - $104K *
Empower patient care by providing essential nursing services across diverse settings. Collaborate with healthcare teams to ensure optimal patient outcomes while enjoying flexible scheduling and compet...
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$100K - $120K *
Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...
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$210K - $250K *
Contribute to a patient-focused care environment by managing evaluations, diagnoses, and treatments. Collaborate within a multidisciplinary team to promote health education and ensure quality care ali...
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Director, Field Reimbursement (FRM)
$210K - $250K *
Empower a dynamic team of reimbursement professionals to enhance provider access and education. Drive strategic initiatives, foster collaboration, and ensure compliance while navigating complex payer...
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Principal Product Quality Leader
$138K - $187K *
Lead cross-functional quality initiatives to enhance product health and compliance. Collaborate with diverse teams on regulatory submissions, quality assessments, and process improvements for late-sta...
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$93K - $104K *
Join a dynamic team to deliver high-quality audiologic evaluations remotely. Leverage your expertise in a supportive environment, enhancing patient care while minimizing administrative burdens and max...
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Director, Client Coding Integration
$97K - $145K *
Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...
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Director, Patient Access (Travel)
$92K - $125K *
Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...
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Behavioral Health Medical Director
$215K - $408K *
Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...
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Associate Director, Medical Strategic Operations (Field)
$175K - $219K *
Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...
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What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.