Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$111K - $167K *

Join a team that's driving healthcare transformation by leading client integration initiatives. Collaborate across departments to ensure seamless transitions, operational readiness, and long-term succ...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$112K - $189K *

Join us to ensure safe, effective medication therapy while advancing pharmaceutical care. Collaborate with healthcare teams, educate future practitioners, and support drug-related research to optimize...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$72K - $104K *

Elevate nursing standards by supervising clinical staff, ensuring compliance with policies, and delivering quality patient care in a correctional environment. Collaborate with healthcare teams to enha...

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Innovate data-driven product strategies by leading informatics initiatives, ensuring rigorous testing and quality assessments while collaborating across teams to enhance client services and streamline...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$93K - $104K *

Join a team that's dedicated to providing exceptional patient care while enjoying flexible scheduling options. As a Registered Nurse, you'll play a vital role in assessing and supporting patients in v...

Today

  •   Less than 5 years exp.  •   Healthcare

$69K - $119K *

Transform the landscape of clinical documentation by educating and mentoring teams, ensuring compliance, and enhancing documentation accuracy to optimize patient care and coding outcomes...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$82K - $132K *

Unlock potential in revenue cycle management by leading innovative solutions, optimizing processes, and collaborating across departments to enhance operational efficiency and maximize revenue impact...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$134K - $249K *

Lead the charge in enhancing clinical systems operations, driving efficiency and effectiveness across pharmacy initiatives while managing a dedicated team and overseeing complex workflows and data int...

RemoteRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Drive strategic clinical operations and program development to enhance patient outcomes. Lead a multidisciplinary team, ensuring compliance and effective care coordination across acute and post-acute...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$110K - $200K *

Join a team that's dedicated to advancing clinical research by leading operational aspects of trials, ensuring compliance with protocols and regulations, and fostering collaboration among stakeholders...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$83K - $87K *

Deliver exceptional patient care by providing skilled nursing services in various settings. Collaborate with healthcare teams to enhance patient outcomes while enjoying flexible scheduling and competi...

Today

  •   Less than 5 years exp.  •   Healthcare

$187K - $281K *

Redefine market access strategies by leading payer engagement to enhance patient access to genomic testing. Collaborate cross-functionally to drive favorable coverage and reimbursement policies, ensur...

United StatesRemote

Today

  •   15+ years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Lead the evaluation of outpatient referrals and inpatient admissions for medical necessity, utilizing guidelines and criteria to ensure quality care. Collaborate with providers and mentor UM nurses to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Drive strategic growth and operational excellence in cardiology, fostering physician partnerships and overseeing clinical and financial performance to enhance patient care and organizational success...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$93K - $104K *

Empower patient care by providing essential nursing services across diverse settings. Collaborate with healthcare teams to ensure optimal patient outcomes while enjoying flexible scheduling and compet...

Today

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Elevate your career by designing and optimizing EpicCare Ambulatory workflows. Collaborate with clinicians to enhance EHR functionality, troubleshoot issues, and ensure seamless operations across heal...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$210K - $250K *

Contribute to a patient-focused care environment by managing evaluations, diagnoses, and treatments. Collaborate within a multidisciplinary team to promote health education and ensure quality care ali...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Empower a dynamic team of reimbursement professionals to enhance provider access and education. Drive strategic initiatives, foster collaboration, and ensure compliance while navigating complex payer...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$138K - $187K *

Lead cross-functional quality initiatives to enhance product health and compliance. Collaborate with diverse teams on regulatory submissions, quality assessments, and process improvements for late-sta...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$93K - $104K *

Join a dynamic team to deliver high-quality audiologic evaluations remotely. Leverage your expertise in a supportive environment, enhancing patient care while minimizing administrative burdens and max...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$97K - $145K *

Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$92K - $125K *

Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$215K - $408K *

Drive medical leadership in quality improvement and utilization management, ensuring effective care delivery and cost containment. Collaborate with clinical teams to enhance patient outcomes and suppo...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$175K - $219K *

Help us elevate Field Medical operations by optimizing processes, enhancing communication, and driving strategic initiatives to ensure effective engagement and alignment across teams in a dynamic heal...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.