Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Obstructive Sleep Apnea Clinical Manager
$120K - $140K *
Transform patient care by leading a team of Field Clinical Specialists, ensuring high-quality clinical education and support. Drive clinical outcomes through effective management, collaboration, and c...
3 weeks ago
Regional Clinical Trial Management Associate
$72K - $97K *
Accelerate progress at clinical trials by supporting regional study delivery, ensuring quality standards, and collaborating with key stakeholders to meet study goals within timelines and budget...
3 weeks ago
$146K - $189K *
Partner with us to enhance our community health provider network. Leverage your expertise in provider relations and network management to drive growth, improve access to care, and support our mission...
3 weeks ago
Senior Manager, Medical Information and Medical Capabilities
$130K - $155K *
Elevate your career by joining a dynamic Medical Affairs team, where you'll lead Medical Information initiatives, ensure compliance, and drive strategic insights to support our innovative pipeline in...
3 weeks ago
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
Director, Rebate Product Program
$173K - $200K *
Elevate rebate product strategy by leading development, driving growth, and enhancing operational performance. Collaborate across teams to ensure compliance and deliver measurable outcomes that align...
3 weeks ago
Strategy & Operations - Coding Optimization and Automation Consultant
$125K - $235K *
Champion healthcare coding excellence by optimizing operations, implementing automation, and enhancing training. Collaborate with leaders to drive measurable improvements in productivity and accuracy...
3 weeks ago
$110K - $130K *
Reimagine medical communication by leading a team of writers to craft regulatory and scientific documents. Oversee projects, ensuring clarity and quality for diverse audiences while adhering to timeli...
Reposted 3 weeks ago
Senior Quality Operations Specialist, Audit
$74K - $98K *
Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...
3 weeks ago
Lead Clinical Pharmacist, Oncology Programs
$120K - $145K *
Join a team that's redefining oncology care by overseeing clinical standards, evaluating therapies, and engaging with providers. You'll play a key role in shaping patient eligibility and treatment pro...
3 weeks ago
Clinical Application Specialist
$80K - $90K *
Shape the future of Cell and Gene Therapy by providing expert application support, driving customer integration, and enhancing product utilization through collaboration and technical guidance across t...
3 weeks ago
Hospital Coding Quality Integrity Analyst - Inpatient
$73K - $110K *
Elevate your career by ensuring coding accuracy and compliance in a dynamic healthcare environment. Collaborate with teams to enhance documentation quality and drive improvements in coding practices w...
3 weeks ago
Senior Manager, In-Vitro Diagnostics/Precision Medicine Quality
$132K - $178K *
Champion quality in In-Vitro Diagnostics and Companion Diagnostics. Lead proactive strategies, ensuring compliance in clinical trials while collaborating with partners to enhance precision medicine in...
3 weeks ago
$150K - $235K *
Join a team that's shaping the future of Medical Affairs by driving strategic client engagements and enhancing capabilities. This Director-level role balances client delivery and internal growth, focu...
3 weeks ago
Revenue Cycle Managed Services - Revenue Integrity Lead
$120K - $145K *
Elevate healthcare revenue integrity by leading client engagements focused on optimizing revenue cycles, enhancing compliance, and driving financial performance through strategic recommendations and d...
3 weeks ago
LMFT / LCSW / LPCC / PsyD | Remote Mental Health Therapist | Nationwide
$150K - $200K *
Transform lives by providing virtual therapy and developing personalized treatment plans. Collaborate with a dedicated team to deliver compassionate, evidence-based care while enjoying the flexibility...
3 weeks ago
Clinical Science Liaison (CSL)
$150K - $180K *
Innovate healthcare delivery by serving as a clinical liaison, translating partner needs into actionable insights for chronic care and telehealth programs, impacting thousands of patients nationwide t...
3 weeks ago
$83K - $93K *
Drive impactful change by empowering youth and young adults through tailored behavioral health support. Utilize your expertise in therapy and wellness coaching to foster sustainable growth and monitor...
3 weeks ago
Manager, Revenue Cycle Operations
$100K - $130K *
Join a dynamic team to lead and enhance billing and coding operations, ensuring quality and compliance across multiple markets. Drive performance, coach leaders, and collaborate cross-functionally to...
3 weeks ago
Senior Quantitative Researcher - CMMI Evaluations
$120K - $150K *
Unlock potential by leading complex evaluations in healthcare innovation. Collaborate with a diverse team to enhance Medicare and Medicaid services through rigorous research, technical expertise, and...
3 weeks ago
Payment Integrity Clinical Readmission Manager
$73K - $125K *
Transform clinical review processes by conducting thorough prepayment and post-payment assessments of inpatient admissions. Leverage your expertise to ensure compliance, support appeals, and enhance q...
3 weeks ago
$140K - $170K *
Elevate your career by managing a dynamic Palliative Care Program, providing clinical expertise, and leading a dedicated team. Drive process improvements and ensure high-quality patient care while fos...
3 weeks ago
Associate Director, Global Value & Access, Hematology
$153K - $203K *
Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...
3 weeks ago
Director, GCP Inspection Management- Americas
$172K - $232K *
Lead the GCP Inspection Management team to ensure inspection readiness and compliance. Oversee strategy development, cross-functional collaboration, and risk mitigation for successful regulatory inspe...
3 weeks ago
$100K - $120K *
Lead the charge in enhancing rehabilitation operations across multiple facilities. Drive clinical excellence, manage staff, and ensure compliance while fostering a supportive environment for both pati...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.