Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$129K - $216K *

Drive impactful partnerships in oncology research by managing site relationships, optimizing clinical trial execution, and enhancing operational efficiency for successful outcomes in a dynamic researc...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$170K - $200K *

Unlock your potential in a dynamic anesthesia role, collaborating with a skilled team to deliver exceptional patient care. Enjoy a balanced schedule with generous time off while managing diverse surgi...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$75K - $90K *

Champion patient care by utilizing telehealth technologies to deliver high-quality nursing services. Collaborate with interdisciplinary teams to improve outcomes and ensure compliance with healthcare...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$80K - $95K *

Unlock your potential by analyzing Medicaid data to enhance program performance, quality, and access. Collaborate with diverse teams to develop insights that drive impactful decisions in healthcare an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $250K *

Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$71K - $118K *

Engage in advanced nuclear imaging procedures, ensuring patient safety and quality care. Collaborate with a skilled team using state-of-the-art technology to deliver diagnostic and therapeutic service...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Lead the nursing program in a long-term care facility, ensuring high resident care standards and compliance with regulations. Collaborate with staff and administration to enhance the quality and effic...

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $100K *

Inspire your career with a role supporting physicians and enhancing patient recovery through hands-on medical care, assessments, and collaboration in a dynamic healthcare environment...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$85K - $100K *

Deliver exceptional mixed animal veterinary care, utilizing advanced equipment and collaborating with a skilled team to enhance patient outcomes while building meaningful client relationships...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Join a dynamic team to develop and deliver clinical training programs, ensuring high-quality education for partners and stakeholders. Act as a subject-matter expert while fostering relationships to en...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $176K *

Elevate medical information operations by managing inquiries, developing responses, and ensuring compliance. Collaborate with healthcare professionals to deliver high-quality communication and support...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$109K - $163K *

Elevate operational excellence in credentialing and compliance across healthcare entities. Lead teams to ensure timely onboarding, regulatory adherence, and quality assurance while fostering collabora...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$77K - $105K *

Join a dynamic team to analyze healthcare claims data, identify fraud trends, and support the Healthcare Fraud Prevention Partnership. Leverage your expertise to drive strategic outcomes and enhance c...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$105K - $160K *

Contribute to compassionate end-of-life care for pets, practicing independently while enjoying a flexible schedule. Join a supportive team dedicated to meaningful work that honors pets and their famil...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $110K *

Transform clinical data into engaging scientific content with growth opportunities. Collaborate, communicate, and adhere to guidelines in a dynamic environment, supporting varied projects across forma...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $99K *

Elevate care standards by providing individualized nursing support to residents. Collaborate with families and interdisciplinary teams to ensure effective health maintenance and treatment, while leadi...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$173K - $310K *

Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$80K - $110K *

Join a team that's dedicated to transforming complex scientific data into clear, impactful content. Collaborate with peers to ensure accuracy and adherence to guidelines while developing crucial mater...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Join a dynamic healthcare team as you manage complex patient populations, collaborating with physicians and nurses to deliver high-quality care. Utilize your expertise in a predominantly outpatient se...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$155K - $175K *

Empower healthcare professionals by delivering scientific insights and fostering relationships. Drive prelaunch and launch strategies in a dynamic environment, ensuring clinical readiness and impactfu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$105K - $115K *

Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$222K - $356K *

Unlock your potential as a Senior Safety Physician, leading safety oversight for late-stage CNS clinical development. Collaborate with cross-functional teams to drive risk management and regulatory su...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$177K - $338K *

Innovate the global medical strategy for a leading drug program. Drive launch readiness, evidence generation, and cross-functional partnerships while serving as the primary medical voice in product li...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.