Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Site Engagement Associate Director - Respiratory
$129K - $216K *
Drive impactful partnerships in oncology research by managing site relationships, optimizing clinical trial execution, and enhancing operational efficiency for successful outcomes in a dynamic researc...
Reposted 2 weeks ago
$170K - $200K *
Unlock your potential in a dynamic anesthesia role, collaborating with a skilled team to deliver exceptional patient care. Enjoy a balanced schedule with generous time off while managing diverse surgi...
2 weeks ago
$75K - $90K *
Champion patient care by utilizing telehealth technologies to deliver high-quality nursing services. Collaborate with interdisciplinary teams to improve outcomes and ensure compliance with healthcare...
Reposted 2 weeks ago
$110K - $130K *
Join a team that's leading Medicaid programs and initiatives, driving operational excellence and policy implementation while managing multidisciplinary teams and enhancing organizational performance a...
2 weeks ago
Medicaid Data & Analytics Specialist
$80K - $95K *
Unlock your potential by analyzing Medicaid data to enhance program performance, quality, and access. Collaborate with diverse teams to develop insights that drive impactful decisions in healthcare an...
2 weeks ago
$120K - $250K *
Transform clinical trials by ensuring patient safety and scientific integrity. Collaborate with stakeholders to uphold regulatory standards and optimize study protocols, while providing expert medical...
2 weeks ago
$71K - $118K *
Engage in advanced nuclear imaging procedures, ensuring patient safety and quality care. Collaborate with a skilled team using state-of-the-art technology to deliver diagnostic and therapeutic service...
Reposted 2 weeks ago
Director of Nursing - RN - Long Term Care
$85K - $100K *
Lead the nursing program in a long-term care facility, ensuring high resident care standards and compliance with regulations. Collaborate with staff and administration to enhance the quality and effic...
Reposted 2 weeks ago
Certified Physician Assistant/ Certified Nurse Practitioner
$85K - $100K *
Inspire your career with a role supporting physicians and enhancing patient recovery through hands-on medical care, assessments, and collaboration in a dynamic healthcare environment...
Reposted 2 weeks ago
Mixed Animal Veterinarian at Sturgis Veterinary Hospital and Equine Center
$85K - $100K *
Deliver exceptional mixed animal veterinary care, utilizing advanced equipment and collaborating with a skilled team to enhance patient outcomes while building meaningful client relationships...
Reposted 2 weeks ago
Manager, Clinical Product Training (Northeast)
$110K - $130K *
Join a dynamic team to develop and deliver clinical training programs, ensuring high-quality education for partners and stakeholders. Act as a subject-matter expert while fostering relationships to en...
2 weeks ago
IB Temporary - Medical Information Specialist
$160K - $176K *
Elevate medical information operations by managing inquiries, developing responses, and ensuring compliance. Collaborate with healthcare professionals to deliver high-quality communication and support...
2 weeks ago
Director, Credentialing & Accreditation
$109K - $163K *
Elevate operational excellence in credentialing and compliance across healthcare entities. Lead teams to ensure timely onboarding, regulatory adherence, and quality assurance while fostering collabora...
2 weeks ago
Healthcare Coding Expert (certified professional coder)
$77K - $105K *
Join a dynamic team to analyze healthcare claims data, identify fraud trends, and support the Healthcare Fraud Prevention Partnership. Leverage your expertise to drive strategic outcomes and enhance c...
2 weeks ago
Hospice Veterinarian | Your Set The Hours | No Non-Compete | United States
$105K - $160K *
Contribute to compassionate end-of-life care for pets, practicing independently while enjoying a flexible schedule. Join a supportive team dedicated to meaningful work that honors pets and their famil...
2 weeks ago
Medical Writer, Medical Communications
$80K - $110K *
Transform clinical data into engaging scientific content with growth opportunities. Collaborate, communicate, and adhere to guidelines in a dynamic environment, supporting varied projects across forma...
Reposted 2 weeks ago
$66K - $99K *
Elevate care standards by providing individualized nursing support to residents. Collaborate with families and interdisciplinary teams to ensure effective health maintenance and treatment, while leadi...
2 weeks ago
Principal Clinical Content- Physician (Clinical AI Strategist - UpToDate®) - Partnerships
$173K - $310K *
Transform clinical AI solutions by leveraging your expertise in patient care and research. Collaborate cross-functionally to enhance clinical accuracy and support strategic partnerships, ensuring the...
2 weeks ago
Medical Writer, Medical Communications
$80K - $110K *
Join a team that's dedicated to transforming complex scientific data into clear, impactful content. Collaborate with peers to ensure accuracy and adherence to guidelines while developing crucial mater...
Reposted 2 weeks ago
Advanced Practice Provider - Clinical Research Oncology
$85K - $100K *
Join a dynamic healthcare team as you manage complex patient populations, collaborating with physicians and nurses to deliver high-quality care. Utilize your expertise in a predominantly outpatient se...
2 weeks ago
Medical Science Liaison, Central US (Multiple Territories)
$155K - $175K *
Empower healthcare professionals by delivering scientific insights and fostering relationships. Drive prelaunch and launch strategies in a dynamic environment, ensuring clinical readiness and impactfu...
2 weeks ago
$110K - $130K *
Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...
2 weeks ago
$105K - $115K *
Optimize medical device utilization in health systems by leveraging expertise in cardiovascular, interventional radiology, and general surgery. Collaborate with stakeholders to drive cost reduction an...
2 weeks ago
Senior Safety Physician - CNS (remote)
$222K - $356K *
Unlock your potential as a Senior Safety Physician, leading safety oversight for late-stage CNS clinical development. Collaborate with cross-functional teams to drive risk management and regulatory su...
Reposted 2 weeks ago
Senior Director, Global Medical Affairs
$177K - $338K *
Innovate the global medical strategy for a leading drug program. Drive launch readiness, evidence generation, and cross-functional partnerships while serving as the primary medical voice in product li...
Reposted 2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.