Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Director, 211 Manufacturing Quality and Regulatory Affairs
$190K - $228K *
Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...
Reposted 2 weeks ago
Perinatal Mental Health Therapist (Remote)
$80K - $85K *
Lead transformative maternal mental health initiatives by providing evidence-based therapy, collaborating with interdisciplinary teams, and advocating for client needs to enhance program effectiveness...
2 weeks ago
Director of Community Behavior Health Program
$80K - $95K *
Lead the strategic development and oversight of community behavioral health programs, ensuring high-quality, culturally responsive services. Collaborate with stakeholders to enhance community wellness...
2 weeks ago
Associate Director, Clinical Operations
$130K - $160K *
Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...
2 weeks ago
San Antonio, TX based Clinical Specialist - Remote, USA
$100K - $140K *
Empower patient care by providing clinical support and training to surgical teams. Collaborate closely with healthcare professionals to ensure optimal outcomes and maintain equipment standards while m...
2 weeks ago
Executive Director, Clinical Supply Consulting & Intelligence
$250K - $350K *
Lead the development of a clinical supply consulting practice, combining expertise in forecasting, planning, and optimization to enhance decision-making for sponsors. Drive innovation and commercial g...
2 weeks ago
Medical Director, Occupational Health & Workers' Compensation Managed Care
$300K *
Elevate healthcare delivery by leading a dedicated team in clinical evaluations, ensuring best practices while providing client-facing support and expertise in medical claims, regulations, and emergin...
Reposted 2 weeks ago
$80K - $95K *
Transform credentialing operations by leading a dedicated team to ensure compliance, enhance efficiency, and support provider network growth through strategic oversight and process improvement initiat...
2 weeks ago
$80K - $95K *
Advance care quality by leading nursing services in Assisted Living and Memory Care. Foster a compassionate environment that empowers residents and supports team excellence, ensuring holistic, person...
2 weeks ago
Director, Managed Markets - Regional - Central
$235K - $270K *
Drive your career forward by leading access strategies across the Central region. Manage key payer relationships and ensure launch readiness for rare disease products while collaborating with cross-fu...
2 weeks ago
Healthcare Claims Payment Policy Managing Consultant
$113K - $188K *
Shape the future of healthcare reimbursement by developing and implementing payment policies that enhance accuracy, compliance, and provider experience in a dynamic payer environment. Collaborate with...
2 weeks ago
$140K - $168K *
Transform nursing operations across multiple skilled nursing facilities by providing clinical oversight, mentorship, and support. Collaborate with leadership to ensure high-quality care, regulatory co...
2 weeks ago
Senior Manager, Clinical Trial Disclosure & Transparency
$132K - $199K *
Join a team that's committed to transparency in clinical trials, ensuring compliance with global disclosure regulations. This role blends operational and strategic tasks, fostering collaboration and q...
2 weeks ago
Clinical Program Lead (CPL) - RLT Focus
$248K - $461K *
Grow your career with us by providing strategic medical leadership for oncology agent development, coordinating clinical strategies, guiding trials, and collaborating with international experts to dri...
Reposted 2 weeks ago
Associate Manager, Clinical Claims
$109K - $136K *
Drive accurate, evidence-based clinical claims while collaborating with Marketing, Legal, and Clinical teams. Build and manage the claims framework and evidence library to support bold, compliant mark...
2 weeks ago
$85K - $90K *
Elevate community engagement by building trusted relationships with senior living staff and residents. Act as a vital connector, ensuring seamless access to on-site care services while fostering colla...
2 weeks ago
Psychiatric Complaints and Grievances Specialist (Remote)
$80K - $95K *
Lead the clinical review and resolution of psychiatric complaints, enhancing care quality across the network. Collaborate with clinical teams, investigate cases, and provide direct patient care, ensur...
2 weeks ago
$110K - $130K *
Join us to lead the development and execution of clinical study designs, ensuring effective project management and collaboration across teams. Your expertise will drive the success of clinical trials...
2 weeks ago
Medical Oncologist, Clinical Care Lead
$275K - $350K *
Transform cancer care by delivering high-quality, evidence-based oncology services via telehealth. Collaborate with multidisciplinary teams to enhance patient outcomes and develop innovative care mode...
2 weeks ago
Director, Neurology - Thought Leader Liaison (Central)
$245K - $265K *
Optimize partnerships with Medical Experts to enhance neurology care. Drive strategic insights and educational initiatives while collaborating across teams to influence business decisions and improve...
2 weeks ago
$80K *
Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...
2 weeks ago
Director of Clinical Strategy - Compliance Suite (ControlCheck & PrivacyPro)
$130K - $150K *
Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...
Reposted 2 weeks ago
Senior Clinical Research Associate - US - West Coast - FSP
$110K - $130K *
Advance your career by providing expert monitoring for clinical trials, ensuring compliance with GCPs and SOPs. Collaborate with study teams, mentor peers, and enhance site performance through effecti...
2 weeks ago
$150K - $180K *
Pioneer innovative strategies as a Medical Science Liaison, engaging with key opinion leaders and driving platform adoption. Collaborate across teams to translate clinical needs into actionable insigh...
2 weeks ago
RN, Cancer Screening & Prevention
$110K - $120K *
Advance patient care at our Virtual Cancer Clinic by providing essential support, education, and coordination for cancer screening and prevention, ensuring timely follow-up and compassionate care for...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.