Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Senior Director, Medical Affairs Strategy & Launch--Hematology
$247K - $309K *
Unlock potential by leading medical strategy for hematologic malignancies. Collaborate cross-functionally to drive evidence generation, stakeholder engagement, and launch readiness, ensuring impactful...
1 week ago
Care Manager RN - UM (Full-Time) Weekends (Remote)
$68K - $105K *
Advance healthcare quality by implementing utilization management strategies. Analyze data for provider enhancement and member satisfaction, while promoting efficient care delivery through collaborati...
Reposted 1 week ago
$85K - $105K *
Join a team that's dedicated to delivering impactful medical communications. As a Senior Account Manager, you'll lead strategic projects for pharmaceutical clients, ensuring quality and timely executi...
1 week ago
Regional Medical Science Director (South)
$200K - $235K *
Unlock potential by driving scientific excellence as a strategic partner, educating healthcare professionals on Immuno-Oncology and fostering relationships that support cancer therapeutic initiatives...
Reposted 1 week ago
Remote Telehealth Registered Dietitian | FT W2
$65K - $105K *
Contribute to transformative care for underserved women by analyzing assessments, providing counseling, and collaborating with healthcare professionals in a fully remote setting. Your expertise will e...
1 week ago
Field Reimbursement Manager - Northern CA
$185K - $230K *
Shape the future of community access by developing strategies to optimize reimbursement processes, collaborating with stakeholders, and ensuring compliance with healthcare regulations while enhancing...
1 week ago
Nurse Practitioner or Physician Assistant | Neurology | Inpatient
$90K - $110K *
Take ownership of patient care by assessing, diagnosing, and treating individuals. Collaborate with physicians to develop care plans, educate patients, and ensure quality health services in a supporti...
1 week ago
Registered Nurse (RN) | Med Surg
$67K - $100K *
Shape the future of patient care by delivering comprehensive nursing services, developing care plans, and providing emotional support to patients and families while collaborating with healthcare teams...
1 week ago
Senior Director/VP - Translational Medicine & Pharmacology
$210K - $250K *
Drive the translational strategy for immunology therapies, focusing on biomarker development and clinical pharmacology. Collaborate cross-functionally to advance pipeline assets and support regulatory...
1 week ago
Clinical Applications Specialist, General Imaging Ultrasound- Boston
$110K - $165K *
Join a team that's dedicated to enhancing clinical education and customer experience. In this role, you'll drive training strategies and support ultrasound product implementation, impacting patient ca...
1 week ago
U.S. Director of Medical Affairs (US DMA) - Ophthalmology
$190K - $300K *
Transform medical affairs by driving scientific excellence and strategic initiatives in ophthalmology. Collaborate with cross-functional teams to enhance field readiness and optimize engagement across...
1 week ago
$69K - $100K *
Optimize coding operations by leading a team to ensure compliance, accuracy, and efficiency in billing processes. Collaborate with stakeholders to enhance documentation quality and coding integrity wh...
1 week ago
Clinical Development Medical Director, Obesity/Cardiovascular
$274K - $371K *
Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...
Reposted 1 week ago
Senior Manager - APR DRG Concept Development Analyst
$100K - $125K *
Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...
1 week ago
IOM Technologist-Traveler East Coast
$80K - $95K *
Champion patient safety by monitoring neuromuscular function during surgeries. Collaborate with surgical teams to ensure optimal outcomes through real-time data analysis and communication, making a si...
1 week ago
Director, Client Coding Integration
$97K - $145K *
Join a team that's dedicated to ensuring accurate coding and compliance for clinical services, leveraging your expertise to enhance revenue cycle management and contribute to optimal healthcare outcom...
Reposted 1 week ago
Director, Client Coding Integration
$120K - $145K *
Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...
Reposted 1 week ago
Clinical Trial Manager/Sr Clinical Trial Manager
$145K - $190K *
Join a team dedicated to advancing oncology clinical trials. In this role, you’ll manage global studies, oversee vendors, collaborate with multi-disciplinary teams, and ensure compliance with regulato...
Reposted 1 week ago
Director, PB Coding Operations & Education
$122K - $177K *
Lead coding operations and education initiatives to ensure compliance, accuracy, and optimal reimbursement across the organization. Manage staff training and oversee coding standards while collaborati...
1 week ago
Manager, Medical Affairs MSL / External Scientific Engagement (Nutrition)
$128K - $176K *
Take ownership of scientific partnerships with healthcare professionals, driving evidence generation and strategic initiatives. Collaborate across teams to enhance patient care and strengthen scientif...
1 week ago
Research Associate, Core Lab (Echocardiography)
$56K - $109K *
Empower our team by quantifying core laboratory studies and ensuring compliance with industry standards. Collaborate with multidisciplinary teams to enhance echocardiography analysis and contribute to...
1 week ago
Sr. Sustainability Engineer - Radiopharmaceutical Manufacturing
$110K - $130K *
Innovate your career with a key role supporting the global launch and technical operations of radiopharmaceuticals, driving compliance, quality initiatives, and collaboration with CDMOs while leading...
Reposted 1 week ago
Senior Medical Physicist (Truckee, CA)
$190K - $262K *
Join us to ensure high-quality radiation therapy through expert oversight, compliance, and innovative practices. Collaborate with a dedicated team to enhance patient safety and deliver exceptional car...
1 week ago
Customer Service Engineer - Union - MR/CT - NY Metro
$133K - $153K *
Provide exceptional service by installing, troubleshooting, and maintaining MRI and CT equipment. Foster strong customer relationships while managing service performance and operations in the NY Metro...
Reposted 1 week ago
Pharmacist Account Manager - Remote Nevada
$108K - $184K *
Unlock potential by leveraging clinical expertise to enhance pharmacy benefit management, analyze drug trends, and build strong client relationships. Drive strategic recommendations and support client...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.