Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Healthcare Jobs in South Dakota

Average Salary in USD

Average Salary: $119,100

Sort By: Relevance

$110K - $130K *

Elevate global post-market surveillance by leading a team focused on safety, compliance, and performance of medical devices. Drive field actions, analyze data, and collaborate cross-functionally to en...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$64K - $96K *

Engage in comprehensive risk adjustment audits and compliance reviews, ensuring accurate data submission to CMS. Collaborate with coding teams and management to uphold regulatory standards and improve...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Join a dynamic team to oversee clinical research activities, ensuring compliance with regulatory standards and driving site performance. Collaborate with stakeholders to enhance patient safety and dat...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$70K - $115K *

Empower your career by joining a dynamic team focused on healthcare compliance auditing. Utilize your analytical skills to drive impactful audits and contribute to client deliverables while receiving...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$83K - $91K *

Empower pediatric patients by delivering skilled nursing care in home settings. Collaborate with healthcare teams to ensure safety and well-being while managing complex medical needs and providing com...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$67K - $100K *

Join a dedicated team providing compassionate nursing care and support to residents, families, and healthcare colleagues. Develop care plans, evaluate outcomes, and ensure a safe environment while pro...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$60K - $129K *

Partner with us to enhance health outcomes through a comprehensive, collaborative case management approach, engaging with clients and healthcare providers to optimize care plans and ensure quality ser...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$133K - $191K *

Transform revenue cycle operations by leading strategic initiatives, optimizing performance, and fostering collaboration across business units to enhance service delivery and achieve organizational go...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $165K *

Join a dynamic team as a Managing Consultant, driving innovative solutions in Revenue Integrity. Oversee engagements, enhance client relationships, and lead project teams to optimize financial perform...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$74K - $89K *

Elevate healthcare quality by reviewing medical records, ensuring accurate coding, and maintaining compliance with guidelines. Collaborate with teams to enhance coding practices and uphold high standa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Elevate patient care by providing expert pharmacy consulting and clinical services. Collaborate with a dedicated team to ensure medication safety and mentor future pharmacists while enjoying growth op...

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Join us to oversee pharmacy services, ensuring quality care through effective planning, execution, and evaluation. Collaborate with healthcare teams to enhance patient outcomes while supervising staff...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Shape the future of compassionate care by leading a multidisciplinary team to enhance the quality of life for patients in their final stages, ensuring comfort, dignity, and emotional support through p...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$274K - $371K *

Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$77K - $85K *

Empower individuals by providing tailored occupational therapy to enhance daily living skills, social engagement, and emotional regulation. Collaborate with interdisciplinary teams to develop personal...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$160K - $259K *

Lead the charge in optimizing global drug safety operations, ensuring compliance and excellence in pharmacovigilance. Drive strategic initiatives, manage vendor relationships, and enhance processes to...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $149K *

Unlock potential by leading healthcare data analytics to enhance hospital quality performance and rankings. Collaborate with teams to design dashboards, mentor analysts, and present insights to execut...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$65K - $108K *

Lead the charge in ensuring coding accuracy and compliance by reviewing medical records and documentation. Utilize ICD-10 and CPT systems to uphold quality standards while responding to coder inquirie...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$210K - $250K *

Grow your career by providing comprehensive diagnostic radiology services, including consultations and interpretations for a diverse patient population. Collaborate remotely to ensure timely and accur...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Shape the future of clinical informatics by leading national pharmacogenomics initiatives. Collaborate across VA systems to enhance precision medicine, optimize data management, and drive impactful he...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$130K - $176K *

Inspire operational excellence as a strategic leader overseeing 8-10 pharmacies. Drive compliance, enhance patient care, and develop talent while ensuring consistent performance across multiple locati...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$291K *

Engage with a dynamic team as a CRNA in a floating role, providing regional anesthesia across multiple facilities. Enjoy autonomy, diverse cases, and a supportive environment with competitive compensa...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$142K - $177K *

Champion innovative risk adjustment solutions by leveraging deep expertise to enhance payer and provider strategies. Collaborate with cross-functional teams to deliver impactful presentations and driv...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in enhancing enterprise-wide Business Continuity programs, ensuring critical healthcare services remain uninterrupted. Collaborate across teams to strengthen resilience and deliver mea...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$280K - $350K *

Lead the charge in providing exceptional medical care and patient education. Collaborate with a dedicated team to assess, diagnose, and treat patients, ensuring adherence to safety standards and quali...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.