Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
RN - Registered Nurse - Short Stay - FT Days
$66K - $99K *
Play a key role in delivering exceptional outpatient nursing care by assessing, planning, and implementing individualized patient care in collaboration with a multidisciplinary team, ensuring adherenc...
1 week ago
MRI Imaging & Quality Expert (Remote)
$162K - $224K *
Champion innovative MRI solutions by leveraging clinical expertise and project management skills to enhance healthcare performance and patient outcomes. Collaborate with teams to optimize workflows an...
1 week ago
$124K - $171K *
Transform healthcare outcomes by leading large-scale lab diagnostics deals. Drive revenue growth and customer retention through strategic planning, relationship building, and effective execution in a...
1 week ago
Medical Imaging Field Engineer - CT/MI - Hershey, PA
$80K - $110K *
Optimize customer satisfaction by servicing and maintaining medical imaging equipment. Leverage your expertise to install, troubleshoot, and train operators, while managing financial performance and f...
1 week ago
$150K - $180K *
Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...
1 week ago
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
1 week ago
$85K *
Champion the development and oversight of ABA treatment plans while mentoring a dedicated team of Behavior Technicians, ensuring effective collaborations with diverse families for impactful therapeuti...
Reposted 1 week ago
Workday Healthcare Financial Implementation Consultant
$140K - $210K *
Partner with us to drive innovative financial solutions in the healthcare sector. Leverage your Workday expertise for impactful implementations, collaborating closely with teams to transform operation...
Reposted 1 week ago
$85K - $100K *
Transform healthcare analytics by supporting ACOs in the MSSP program. Leverage data-driven insights to track performance metrics, optimize risk scores, and collaborate with teams to enhance value-bas...
1 week ago
Director Field Clinical & Patient Screening Programs
$149K - $298K *
Lead strategic and operational initiatives for field clinical teams, ensuring compliance and effective trial support for TMVR programs while driving positive patient outcomes and team performance...
1 week ago
24/7 Clinical Support Behavioral Licensed Clinician - Evernorth - Remote
$67K - $111K *
Deliver compassionate, expert behavioral health care throughout members' journeys, ensuring clinical excellence in a fast-paced, 24/7 environment as a trusted clinical partner in diverse cases and sup...
Reposted 1 week ago
$80K - $95K *
Join a team that's dedicated to enhancing patient safety through data analysis, audits, and collaboration across departments. Drive improvements in EHR software and support quality initiatives to ensu...
1 week ago
Medical Director, Gastroenterology
$210K - $250K *
Unlock potential by leveraging your GI expertise to enhance product development, strengthen customer relationships, and drive growth in a dynamic SaaS environment. Collaborate across teams to deliver...
1 week ago
$100K - $120K *
Shape the future of patient care by ensuring safe and effective medication use. Collaborate with healthcare professionals to manage treatments, educate patients, and oversee pharmacy operations while...
1 week ago
RN - Registered Nurse - Critical Care Float Pool - Nights
$66K - $99K *
Drive exceptional patient care by utilizing the nursing process to deliver individualized nursing services. Collaborate with a dedicated team to enhance skills and foster innovation in a supportive en...
1 week ago
Director, Clinical Quality Assurance
$195K - $256K *
Elevate clinical quality assurance by designing and executing strategies for compliance, audit management, and oversight of global clinical operations. Collaborate with stakeholders to ensure adherenc...
1 week ago
Physician Assistant or Nurse Practition | Family Medicine
$85K - $100K *
Join a team that's dedicated to providing comprehensive medical care by assessing, diagnosing, and treating patients while promoting health education and collaboration with physicians to enhance patie...
1 week ago
$66K - $106K *
Join a team that's dedicated to conducting thorough medical reviews and applying clinical judgment to ensure compliance and prevent fraud in healthcare claims. Collaborate with professionals to suppor...
1 week ago
$99K - $118K *
Transform your career by leveraging your clinical and coding expertise to defend appeals for healthcare claims. This role demands independent analysis, strong communication, and proficiency in AI tool...
1 week ago
$96K - $116K *
Champion innovative medical policy solutions by analyzing data, ensuring quality, and collaborating across clinical operations. Drive enhancements in payment policy management while supporting diverse...
1 week ago
Healthcare Capture and Opportunity Management Specialist
$80K - $95K *
Drive impactful strategies by leveraging research and insights to advance government health opportunities. Collaborate with leaders to enhance competitive positioning and secure meaningful work that b...
1 week ago
Sr Regional Manager - Contact Center Back Office Support - Patient Access
$72K - $94K *
Transform patient access operations by leading centralized support functions, optimizing workflows, and enhancing service quality across multiple regions. Drive continuous improvement and develop lead...
1 week ago
Manager, Quality Assurance (LTSS)
$104K - $143K *
Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...
1 week ago
Lead RN, Utilization Management
$100K - $130K *
Lead the charge in enhancing member care as you coach and develop clinical teams, oversee daily operations, and ensure compliance with regulatory standards while driving quality improvements and opera...
1 week ago
Pharmacist Full Relocation Package Available
$100K - $120K *
Join a team that's dedicated to providing exceptional pharmacy services, ensuring patient safety, and delivering clinical healthcare. Collaborate with a supportive team while mentoring others and stay...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.