Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
Medical Affairs and Evidence Generation Asset Lead – Executive Director
$325K - $447K *
Elevate medical affairs by providing strategic insights for clinical asset development and commercialization. Lead cross-functional teams, execute evidence generation plans, and foster collaboration t...
Reposted 1 week ago
DRG Quality Analyst IV - Healthcare
$85K - $110K *
Optimize clinical DRG audits by ensuring accuracy and consistency in coding. Mentor auditors, recommend process improvements, and conduct quality reviews to enhance performance and compliance in a rem...
1 week ago
RN Clinical Documentation Informaticist - Remote (see full posting for eligible states)
$80K - $95K *
Advance clinical documentation accuracy by collaborating with healthcare teams to ensure comprehensive patient records, reflecting severity of illness and risk of mortality, while maintaining complian...
1 week ago
Sr. Manager, Claims Operations - Archimedes
$100K - $120K *
Elevate operational excellence by leading claims operations, ensuring compliance and efficiency while driving process improvements and team development. Collaborate across functions to meet client com...
1 week ago
$120K - $150K *
Accelerate progress at the forefront of newborn health by leading strategic initiatives, managing multi-country programs, and driving impactful interventions to reduce neonatal mortality and stillbirt...
1 week ago
$85K - $100K *
Help us optimize Epic applications by leading projects, troubleshooting issues, and ensuring seamless integration. Collaborate with teams to enhance workflows and provide expert support, all while mai...
1 week ago
$190K - $300K *
Build strategic relationships with scientific leaders to drive innovation in Pulmonary Hypertension. Engage in scientific exchange, support research initiatives, and enhance understanding of therapeut...
Reposted 1 week ago
Regional Director of Clinical Operations
$100K - $120K *
Shape the future of healthcare by leading clinical operations across 3-5 skilled nursing facilities in eastern South Dakota, ensuring regulatory compliance and quality care while managing multiple tea...
Reposted 1 week ago
Sr. Manager, Central Monitoring, Data Analysis
$120K - $145K *
Drive impactful data analysis and risk management for global clinical trials, interpreting complex data to identify trends and risks. Lead cross-functional teams in enhancing study quality and patient...
1 week ago
Audit Policy Analyst, Post-Acute Services
$80K - $95K *
Innovate post-acute payment integrity by developing and optimizing audit concepts for DME, home health, and infusion therapy claims. Collaborate cross-functionally to ensure compliance and enhance ope...
1 week ago
HEDIS Quality Programs, Principal
$127K - $157K *
Join a team that's redefining healthcare quality by owning HEDIS performance measures. You'll design and implement impactful programs, collaborate across teams, and drive improvements to enhance patie...
1 week ago
Global Dx Clinical Pathologist
$106K - $172K *
Elevate veterinary care by interpreting digital cytology and hematology cases. Collaborate with veterinarians, ensure quality control, and contribute to outreach efforts while maintaining high standar...
1 week ago
$190K - $300K *
Champion scientific exchange and clinical research in Cardiovascular & Metabolism. Engage with medical leaders, enhance understanding of research goals, and gather insights to drive strategic initiati...
1 week ago
$95K - $110K *
Take ownership of nursing excellence by leading a dedicated team to deliver high-quality care in a supportive environment. Foster relationships and drive clinical practices while ensuring compliance w...
1 week ago
Head of Clinical Quality and Regulatory
$208K - $220K *
Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...
1 week ago
$76K - $148K *
Play a key role in managing clinical trials, ensuring compliance and quality oversight of project deliverables while collaborating with cross-functional teams to meet timelines and budget goals...
Reposted 1 week ago
Associate Director, Clinical Trial Management - Full-Service
$120K - $150K *
Elevate your career by leading clinical trial management teams, ensuring quality and compliance in monitoring strategies. Collaborate with cross-functional teams to optimize clinical operations and dr...
1 week ago
Medical Review Nurse - Commercial DME Auditor
$80K - $95K *
Transform healthcare auditing by conducting thorough medical claims reviews. Collaborate with a dynamic team to ensure compliance and improve processes while working remotely in a fast-paced environme...
1 week ago
$227K - $385K *
Elevate member care by overseeing utilization management and evaluating treatment appropriateness. Collaborate with multidisciplinary teams, ensuring compliance with clinical standards and regulations...
Reposted 1 week ago
RN - Registered Nurse - Short Stay - FT Days
$66K - $99K *
Play a key role in delivering exceptional outpatient nursing care by assessing, planning, and implementing individualized patient care in collaboration with a multidisciplinary team, ensuring adherenc...
1 week ago
MRI Imaging & Quality Expert (Remote)
$162K - $224K *
Champion innovative MRI solutions by leveraging clinical expertise and project management skills to enhance healthcare performance and patient outcomes. Collaborate with teams to optimize workflows an...
1 week ago
$124K - $171K *
Transform healthcare outcomes by leading large-scale lab diagnostics deals. Drive revenue growth and customer retention through strategic planning, relationship building, and effective execution in a...
1 week ago
Medical Imaging Field Engineer - CT/MI - Hershey, PA
$80K - $110K *
Optimize customer satisfaction by servicing and maintaining medical imaging equipment. Leverage your expertise to install, troubleshoot, and train operators, while managing financial performance and f...
1 week ago
$150K - $180K *
Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...
1 week ago
Senior Clinical Scientist - Oncology - Home Based
$110K - $130K *
Transform your career with a pivotal role in clinical research, leading oncology studies and collaborating with cross-functional teams to ensure scientific excellence and regulatory compliance while m...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.