Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
$120K - $150K *
Elevate pediatric dental care by joining our collaborative team, where you'll provide exceptional treatment to children in a supportive, high-volume practice. Enjoy a fulfilling role that fosters last...
6 days ago
$120K - $144K *
Join a team that's dedicated to providing exceptional dental care to children. This role offers the chance to build lasting relationships in a supportive, multi-doctor environment while utilizing mode...
6 days ago
$120K - $145K *
Champion the development of clinical operations by managing a network of providers, establishing policies, and enhancing quality programs. Collaborate with leadership to ensure operational excellence...
6 days ago
STRIDES Laboratory and Diagnostics Advisor, Outbreak Preparedness and Response
$89K - $120K *
Drive initiatives to expand and strengthen laboratory systems for outbreak response and public health, ensuring alignment with national policies and international standards while providing technical l...
Reposted 6 days ago
Sr Manager, Clinical Data Management
$143K - $185K *
Unlock potential by leading clinical data management for innovative cell therapy studies. Collaborate cross-functionally to ensure data integrity and compliance while managing teams and external partn...
Reposted 6 days ago
Senior Medical Science Liaison - Western US
$180K - $190K *
Join a team that's dedicated to advancing precision medicine by leveraging AI to provide cutting-edge educational support and scientific expertise on cancer biomarker tests while engaging key opinion...
Reposted 6 days ago
National Medical Director, Enterprise Partnerships, Remote
$210K - $250K *
Transform healthcare delivery by leading a team of Medical Directors and Clinical Directors, driving clinical strategy and performance excellence across portfolios while fostering relationships and in...
6 days ago
Senior Budget Administrator - Clinical Trials
$100K - $161K *
Advance your career by coordinating clinical trial budgets and coverage analyses. Collaborate with stakeholders to ensure compliance and cost efficiency while mentoring junior staff and enhancing admi...
6 days ago
Managing Consultant, Safety and Reliability
$126K - $153K *
Transform healthcare safety by leading multi-hospital engagements, applying High Reliability Organization principles, and driving operational improvements to enhance patient care and trust across dive...
6 days ago
Executive Director of Medical Services
$250K - $275K *
Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...
6 days ago
$190K - $300K *
Champion scientific exchange and research initiatives in gastrointestinal immunology, engaging with key scientific leaders to enhance understanding and support clinical trials while fostering an inclu...
6 days ago
$90K - $105K *
Advance your career by leading a dedicated team in delivering trauma-informed care for substance use disorders. Shape clinical practices and foster a supportive environment in a new clinic focused on...
Reposted 6 days ago
Associate Director, US Patient Advocacy
$164K - $225K *
Develop and execute patient advocacy strategies, engaging with PAOs and cross-functional teams to elevate the patient voice and ensure successful partnerships for rare disease therapeutic areas...
Reposted 6 days ago
$90K - $110K *
Analyze healthcare data to enhance clinical insights and improve medication use. Collaborate with cross-functional teams to develop analytics tools and real-world evidence studies, driving better heal...
1 week ago
Associate Director, Patient Recruitment and Retention Execution Manager
$194K - $266K *
Champion patient engagement strategies by leading a dynamic team focused on optimizing recruitment and retention across clinical trials. Drive performance, enhance collaboration, and ensure successful...
1 week ago
$84K - $99K *
Join a dynamic team to evaluate and process medication prior authorization requests, ensuring compliance with clinical guidelines and regulatory standards while facilitating timely patient access to n...
1 week ago
Quality Compliance & AI Operations Analyst
$80K - $90K *
Advance quality assurance initiatives and optimize workflows in a remote healthcare contact center. Collaborate cross-functionally to enhance compliance, improve patient outcomes, and drive continuous...
1 week ago
Full Time Remote Daytime Radiologist - Wilkes Barre-1
$250K - $300K *
Unlock your potential as a Diagnostic Radiologist, joining a respected practice with modern technology and a supportive team. Enjoy a balanced lifestyle while delivering exceptional patient care in a...
1 week ago
$210K - $250K *
Drive transformative healthcare initiatives by leading a team of practitioners, optimizing clinical protocols, and enhancing patient care through innovative medical solutions in weight management and...
1 week ago
$227K - $341K *
Lead the strategic development and continuous improvement of clinical programs, focusing on optimizing patient care across the continuum. Oversee a multidisciplinary team to enhance outcomes, reduce h...
1 week ago
Transformation Consultant, Digital Health
$85K - $137K *
Elevate healthcare transformation by coaching clinicians and leaders to optimize operational excellence and improve patient outcomes through effective EHR utilization and workflow redesign. Drive chan...
1 week ago
$193K - $241K *
Lead and oversee Medical Information teams, ensuring high-quality service delivery and compliance. Drive strategic initiatives, manage resources, and collaborate cross-functionally to enhance operatio...
1 week ago
Certified Medical Dosimetrist - Radiation (Remote)
$80K - $95K *
Shape the future of cancer treatment by collaborating with experts to create individualized radiation therapy plans. Leverage advanced tools and techniques in a supportive, fully remote environment fo...
1 week ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...
1 week ago
Medical Affairs Technology and Digital Innovation Director
$190K - $238K *
Transform your career by leading the digital strategy for Medical Affairs. Drive innovation, optimize processes, and enhance scientific communications through emerging technologies while collaborating...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.