Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Average Salary: $119,100
ED, Advance Analytics and Precision Health
$225K - $418K *
Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...
2 days ago
$80K - $95K *
Transform patient access by optimizing Epic Cadence workflows. Collaborate with clinical teams to enhance scheduling efficiency and support system improvements, ensuring seamless operations and superi...
2 days ago
Director, Patient Intelligence Strategy & Governance
$185K - $344K *
Advance enterprise patient intelligence by leading strategy, governance, and analytics. Collaborate across functions to enhance decision-making and drive insights that improve patient outcomes and bus...
2 days ago
Senior Manager Medical Economics
$82K - $182K *
Analyze healthcare costs and quality outcomes to drive value-based care strategies, collaborating with clinical and financial teams. Lead data-driven insights and financial modeling to enhance operati...
Reposted 2 days ago
Licensed Vocational Nurse II, Sutter Coast Harbor Clinic
$77K - $108K *
Join a team that's dedicated to delivering exceptional patient care while utilizing your nursing skills. Collaborate with healthcare professionals to implement care plans and ensure compliance with es...
2 days ago
Biostatistical Programming Manager
$129K - $174K *
Lead a dynamic programming team to enhance data analysis strategies, ensuring high-quality biomedical data presentation while driving efficiency and innovation in a collaborative environment focused o...
2 days ago
Manager, Health Informatics (Pacific Southwest)
$152K - $253K *
Lead strategic health informatics initiatives to enhance care delivery by partnering with health systems and GSK teams, translating data insights into actionable improvements in patient care and opera...
Reposted 2 days ago
Associate Director - Medical Science Liaison, Oncology (GI/Thoracic Focus) - Upper Midwest
$156K - $250K *
Lead the charge in scientific dialogue with key healthcare professionals, providing critical insights and support within your therapeutic area. Utilize your expertise to enhance patient outcomes and f...
Reposted 2 days ago
$110K - $130K *
Optimize clinical trial operations by leading cross-functional teams, managing vendor relationships, and ensuring compliance with regulatory standards to drive successful study execution and patient e...
2 days ago
Associate Director, Study Operations Manager - Nonclinical Toxicology
$129K - $231K *
Elevate nonclinical toxicology operations by managing study execution, ensuring compliance, and fostering collaboration across teams to advance innovative therapies for sleep-wake disorders. Drive acc...
2 days ago
Associate Clinical Research Manager
$105K - $140K *
Champion clinical trial excellence by leading a high-performing CRA team, ensuring compliance with ICH-GCP and local regulations while fostering a positive team culture and optimizing site relationshi...
2 days ago
Senior Medical Science Liaison - Obesity & Related Conditions - IA/NE/SD
$172K - $233K *
Engage with healthcare leaders to advance scientific knowledge and improve patient outcomes in obesity care. Collaborate with internal and external stakeholders, support research initiatives, and ment...
2 days ago
$110K - $130K *
Lead the charge in managing complex clinical trials, ensuring timely delivery, budget adherence, and high-quality outcomes while collaborating with multidisciplinary teams and stakeholders to enhance...
2 days ago
Associate Director, Virtual Health
$115K - $125K *
Elevate virtual health services by leading strategic initiatives, enhancing patient experiences, and driving operational excellence. Collaborate across teams to implement innovative care models and en...
2 days ago
Director, Patient Financial Services (PFS) - Healthcare CBO
$106K - $176K *
Join a team that's transforming healthcare finance by leading patient financial services operations. Drive revenue cycle improvements, manage billing processes, and enhance compliance while fostering...
2 days ago
Clinical Care Leader - Aberdeen Medical Center - Med/Surg - Full Time
$76K - $114K *
Join a team that's dedicated to providing exceptional patient care while collaborating with healthcare professionals. Utilize your nursing expertise to lead and coordinate care in a dynamic medical/su...
2 days ago
Staff Pharmacist - Accredo - Remote (AZ, FL, IN, OH, PA)
$112K - $189K *
Lead the charge in delivering exceptional pharmaceutical care by interpreting prescriptions, consulting with patients, and ensuring quality assurance. Collaborate with healthcare professionals to opti...
2 days ago
$250K - $300K *
Champion innovative neurological care by providing expert medical services to patients. Collaborate with a dedicated team to enhance patient outcomes and advance your practice in a supportive environm...
Reposted 2 days ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Unlock potential by delivering high-quality virtual care as a board-certified OB/GYN. Manage diverse clinical cases through telehealth, ensuring patient-centered treatment while enjoying a flexible sc...
2 days ago
Physician, OB/GYN - Telemedicine Opportunity - DrHouse
$210K *
Shape the future of telehealth by delivering compassionate, patient-centered care. Join a dynamic team of board-certified OB/GYN physicians providing virtual consultations across South Dakota, balanci...
2 days ago
Senior Medical Science Liaison - Rheumatology - Mid-Atlantic
$151K - $237K *
Transform healthcare outcomes by engaging with KOLs and HCPs, analyzing scientific data, and fostering expert networks. Drive medical strategy and enhance patient care through compliant, insightful co...
2 days ago
Registered Nurse (RN) | Women's Center
$67K - $100K *
Elevate patient care by delivering comprehensive nursing services, collaborating with healthcare teams, and providing emotional support to patients and families while ensuring adherence to safety and...
2 days ago
$115K - $158K *
Shape the future of healthcare by leading the Organic Risk Adjustment program. Drive strategic initiatives, foster collaboration across teams, and implement innovative solutions to enhance performance...
2 days ago
Population Health Management — Wellness and Prevention
$115K - $158K *
Shape the future of Medicaid wellness by leading innovative strategies and solutions that enhance health outcomes for underserved populations. Collaborate with diverse teams to develop impactful progr...
2 days ago
Home Health Strategy Advancement Advisor
$104K - $143K *
Empower healthcare transformation by developing strategic initiatives that enhance operational efficiency and clinician productivity. Collaborate cross-functionally to drive impactful solutions and im...
2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.