Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Information Security Architect - AI
$170K - $212K *
Elevate AI security by designing robust frameworks to protect systems from threats. Collaborate with cross-functional teams to ensure compliance and ethical use, while implementing strategies that saf...
3 weeks ago
$182K - $198K *
Build and lead a robust Service Management Office to enhance IT operations, ensuring effective governance, accountability, and continuous improvement across a complex 24x7 environment, while fostering...
2 weeks ago
$88K - $105K *
Join a dynamic team as you lead HR initiatives, fostering a high-performance culture that empowers employees and drives organizational success. Collaborate with leadership to enhance recruitment, trai...
Reposted 2 days ago
Staff Software Engineer, New Products
$130K - $155K *
Unlock potential by rapidly transforming customer insights into innovative prototypes. Collaborate with a dynamic team to build scalable products from scratch, leveraging AI tools and existing platfor...
1 week ago
Staff Product Manager, Longitudinal Patient Record
$188K - $245K *
Drive the vision for a unified longitudinal patient record, ensuring data accuracy and completeness across multiple sources. Collaborate with cross-functional teams to enhance clinical data utility an...
Yesterday
Senior Financial Analyst (Consolidation)
$100K - $120K *
Lead the consolidation of financial models and metrics, partnering with cross-functional teams to deliver actionable insights and support strategic decision-making across the organization...
1 week ago
Life Sciences Commercial, Management Consulting Principal Director
$150K - $375K *
Join a team that's transforming life sciences through strategic commercial leadership. Drive large-scale engagements, foster client relationships, and deliver innovative solutions that enhance operati...
2 weeks ago
Capture Director, Medicaid Proposals
$100K - $231K *
Unlock potential by leading strategic capture management initiatives, collaborating with cross-functional teams to enhance proposal quality and win probability in Medicaid managed care. Drive innovati...
Reposted yesterday
People Program Manager, Payroll
$109K - $144K *
Join a team that's driving strategic payroll initiatives and enhancing operational effectiveness. You'll lead program execution, optimize Workday Payroll systems, and foster collaboration across depar...
Today
Senior Consultant - Regulatory
$110K - $130K *
Shape client success by leading complex consulting projects, integrating diverse workstreams into actionable insights, and driving high-quality deliverables while fostering team growth and managing st...
Reposted 1 week ago
Vice President, Global Therapeutic Area Leader, Oncology
$200K - $450K *
Inspire innovation in global therapeutic strategies, leading scientific expertise and operational execution across a diverse therapeutic landscape, while ensuring high-quality delivery and compliance...
Reposted yesterday
$65K - $109K *
Partner with us to foster strategic relationships, optimize account performance, and drive engagement with key stakeholders, leveraging your knowledge of healthcare technology to deliver impactful sol...
Reposted 2 weeks ago
$110K - $130K *
Contribute to impactful consulting services in government pricing, leveraging your expertise to guide clients through compliance, data analysis, and strategic initiatives while leading a collaborative...
1 week ago
Analyst Sales Analytics (Sales Hub)
$69K - $95K *
Join a team that's dedicated to leveraging data analytics to drive sales success. As a key partner, you'll provide insights and innovative solutions that enhance decision-making and support strategic...
Reposted 3 days ago
Value & Access Insights Sr. Manager, Medical Benefit Products
$163K - $220K *
Shape the future of healthcare by leading analytics for managed care, driving payer strategies, and delivering insights to enhance access to medical benefit products. Collaborate with cross-functional...
4 weeks ago
Critical Care Physician | Mercy Hospital St. Louis | St. Louis, Missouri
$250K - $300K *
Lead the charge in providing exceptional critical care for complex patients. Join a dynamic team at a tertiary teaching hospital, engaging in bedside care, education, and research while enjoying a sup...
Today
$115K - $193K *
Drive innovation in pharmacy automation software development, enhancing efficiency and accuracy. Collaborate cross-functionally to tackle complex challenges and see the impact of your contributions on...
Reposted today
Head and Neck Oncology ENT Mercy Springfield MO Comprehensive Cancer Program at 886 bed Hospital
$240K - $300K *
Contribute to a leading cancer program by joining a collaborative team of experts in head & neck surgery, focusing on microvascular reconstruction and oncology, while enjoying a balanced lifestyle and...
Reposted 1 week ago
$110K - $130K *
Advance client relationships and team performance as a strategic leader, overseeing captive insurance operations, driving excellence, and enhancing service delivery while managing complex engagements...
1 week ago
Senior Director, Analytical Sciences
$215K - $240K *
Shape the future of drug development by leading analytical strategies, ensuring compliance and optimization of processes across lifecycle stages, and collaborating with cross-functional teams and exte...
Reposted today
Director, Mid-Enterprise Sales, Ohio Valley
$325K - $375K *
Lead the charge in driving revenue growth by building and mentoring a high-performing sales team in the Mid-Enterprise segment, focusing on customer acquisition and market penetration in a competitive...
3 weeks ago
Senior Software Engineer, Full-Stack
$140K - $180K *
Champion innovation by developing full-stack web applications using TypeScript. Collaborate in a dynamic, remote-first team to deliver engaging user experiences, streamline operations, and lead techni...
Reposted 3 weeks ago
$110K - $130K *
Drive customer success by managing enterprise accounts, ensuring adoption and satisfaction with cybersecurity solutions. Collaborate cross-functionally to deliver value and strategic alignment through...
3 weeks ago
Lead Technical Product Manager | Healthcare | APIs, Integrations, & Embedded AI Solutions
$128K - $226K *
Unlock potential by leading the delivery of APIs and integrations that enhance healthcare tools. Collaborate with engineering teams to ensure reliable, user-friendly solutions that drive business grow...
3 days ago
Senior Consultant - Outsourced Accounting Services (Non-Profit)
$73K - $127K *
Join our dynamic Outsourced Accounting Team to deliver tailored financial services, manage client accounts, and drive operational excellence. Collaborate with clients and team members to enhance their...
1 week ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.