Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Director, Clinical Operations
$270K - $280K *
Join a team that's driving clinical excellence by overseeing trial execution, managing timelines, budgets, and CROs. Collaborate with stakeholders to ensure compliance and quality while mentoring team...
3 weeks ago
Vice President, Network Development & Contracting
$207K - $392K *
Empower provider network strategy by overseeing contracting, analyzing costs, and supporting market expansion. Lead initiatives to enhance network operations and ensure alignment with company objectiv...
Reposted 3 weeks ago
Associate Director, Business Development (Creative Tools, Game Development, and Learning)
$110K - $155K *
Unlock potential by leading strategic partnerships in Creative Software Licensing. Drive growth through innovative deals, build relationships with developers, and shape the future of digital tools for...
2 weeks ago
Trial Delivery Management (Advanced)
$110K - $130K *
Lead the charge in managing complex projects within the pharmaceutical and biotech sectors, ensuring successful execution and delivery while mentoring teams and collaborating with stakeholders to achi...
2 weeks ago
$160K - $200K *
Contribute to the health of patients as a physician in a supportive psychiatric team, specializing in fields like primary care and geriatrics. Join us in delivering essential medical care in a dynamic...
Reposted 5 days ago
Lead Applied Scientist, NBA – Reinforcement Learning
$129K - $177K *
Champion the development of intelligent decision systems using machine learning and reinforcement learning to enhance personalized healthcare recommendations, driving impactful outcomes for millions o...
1 week ago
Program Manager IV - Clinical Technology Operations
$87K - $157K *
Manage strategic programs and complex projects, ensuring timely delivery while effectively leading cross-functional teams to achieve key business objectives and drive organizational success...
Reposted 4 days ago
$85K - $95K *
Transform data into actionable insights by developing predictive models and automating workflows. Collaborate in a dynamic environment to enhance decision-making and operational efficiency using advan...
Reposted 1 week ago
Medical Review Nurse II - SNF/MDS Auditor
$90K - $105K *
Tackle medical claims audits in a dynamic remote environment, collaborating with a skilled team to ensure compliance and accuracy in Skilled Nursing Facility reviews while enhancing audit processes an...
1 week ago
Analytical Chemistry Staff Scientist
$80K - $95K *
Join a team that's dedicated to delivering high-quality research in a fast-paced environment. Collaborate with diverse scientists to conduct advanced analytical chemistry projects while ensuring compl...
2 days ago
$70K - $110K *
Champion the implementation and support of Windows Server environments, ensuring optimal performance and security across diverse customer infrastructures while collaborating with technical teams and s...
5 days ago
Senior Compliance Analyst - Advertising Review
$85K - $100K *
Champion compliance excellence by reviewing retail communications to ensure adherence to regulations and firm policies. Collaborate with teams to maintain high standards and support organizational goa...
1 week ago
Senior Revenue Operations Analyst
$80K - $100K *
Optimize revenue growth by driving GTM excellence and data-driven insights. Collaborate across Sales, Customer Success, and Finance to establish streamlined operations and enhance performance reportin...
Reposted 3 weeks ago
$110K - $130K *
Shape the future of enterprise data strategy and architecture, ensuring governance, quality, and integration across the organization. Lead modernization efforts and establish standards for data manage...
4 days ago
$82K - $172K *
Design and implement innovative AI solutions, guiding pilot programs from conception to execution while collaborating across teams to enhance system capabilities and performance in a dynamic environme...
Reposted 2 weeks ago
$100K - $120K *
Join a team that's dedicated to enhancing healthcare technology by developing and maintaining our Electronic Health Record platform using Ruby. Collaborate in an agile environment to deliver impactful...
2 weeks ago
$100K - $120K *
Explore opportunities to partner with engineers and stakeholders, translating technical discussions into actionable deliverables while supporting CI/CD initiatives and repository governance with a foc...
3 weeks ago
ASC Development Leader - Central
$114K - $171K *
Join a team that's driving growth in the cardiovascular ASC market by developing strategic relationships and orchestrating complex opportunities across the U.S. Collaborate with diverse stakeholders t...
4 days ago
$100K - $140K *
Transform your career by leveraging your RCM expertise to drive sales success. Collaborate with cross-functional teams to enhance customer experiences and optimize billing solutions for small to mediu...
3 weeks ago
Implementation Business Analyst II
$78K - $126K *
Transform public safety operations by aligning technology solutions with customer needs. Collaborate in a dynamic team to implement an industry-leading SaaS platform, enhancing mission-critical workfl...
Reposted 4 weeks ago
Senior Casualty Claims Specialist - Specialty Human Services
$101K - $146K *
Lead the charge in managing complex casualty claims, ensuring timely evaluations and settlements while collaborating with stakeholders to uphold coverage standards and compliance. Drive efficiency in...
1 week ago
Senior Software Development Engineer
$83K - $222K *
Drive innovation by delivering high-quality web applications and interactive dashboards. Collaborate with cross-functional teams to integrate AI capabilities and build resilient APIs in a fast-paced...
Reposted 2 weeks ago
Senior Director, Client Success
$150K - $180K *
Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...
3 weeks ago
Senior AI/ML Data Model Architect
$204K - $216K *
Unlock potential by designing robust data models that empower AI systems. You will ensure data coherence and quality, bridging knowledge representation and machine learning across diverse communities...
Reposted 6 days ago
$80K *
Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...
Reposted today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.