Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$120K - $145K *
Drive technology strategy by aligning investments with business goals, modernizing applications, and managing risk. Serve as a trusted advisor to leadership, establishing roadmaps and governance for a...
3 days ago
Program Specialist, Care Management
$74K - $119K *
Transform healthcare delivery by coordinating strategic programs that enhance clinical and operational excellence. Collaborate with diverse teams to implement innovative solutions, ensuring compliance...
1 week ago
Scientist, Genomics and Cancer Biology
$101K - $126K *
Explore innovative multimodal genomics to drive impactful research and collaborations. As a key contributor, you'll design and execute studies, translating complex data into actionable insights for bo...
Yesterday
Sr. Director, Ideation Intelligence & Analytics
$197K - $271K *
Transform analytical discovery in healthcare payment integrity by leveraging advanced analytics, AI, and claims data to uncover savings opportunities and drive innovation across the organization, enha...
Yesterday
Healthcare Project Manager- Construction
$88K - $105K *
Oversee project delivery from preconstruction to closeout, ensuring compliance, safety, and quality in healthcare environments. Build strong relationships with stakeholders while managing budgets, sch...
Reposted 4 days ago
Sr. Manager of Medicare Compliance
$110K - $130K *
Champion compliance excellence by leading innovative technology integration and regulatory strategies across Medicare Advantage and Part D channels, ensuring seamless operations and enhanced agent eff...
3 weeks ago
$75K - $158K *
Champion the design and optimization of SAP Forms solutions to enhance logistics and financial operations within a complex SAP S/4HANA environment, collaborating with stakeholders to drive efficiency...
2 days ago
Healthcare Merchant Payment Solutions Consultant- Mid-Market
$126K - $154K *
Empower healthcare organizations by optimizing payment solutions and driving growth. This remote role involves building executive relationships and addressing complex revenue cycle challenges within m...
1 week ago
Lifecycle Acquisition Analyst - Subject Matter Expert
$110K - $130K *
Join a team that's shaping strategic acquisition and program management for complex geospatial initiatives. Lead long-term planning, interface with senior executives, and ensure alignment with agency...
1 week ago
Int Database Reliability Engineer (DBRE)
$111K - $139K *
Drive database reliability by managing and optimizing cloud-based infrastructure. Collaborate with Engineering and SRE teams to enhance performance, automate processes, and support mission-critical ap...
Yesterday
Salesforce Architect | Public Health | Public Sector
$145K - $150K *
Grow your career with a collaborative team focused on public health solutions. As a Senior Salesforce Developer, you'll leverage your expertise to enhance health department systems nationwide within a...
1 week ago
Director - Professional Coding (Remote)
$190K - $252K *
Join a team that's redefining professional coding leadership, overseeing coding operations, quality audits, and education initiatives. Drive strategic objectives that enhance patient care and revenue...
5 days ago
$80K - $95K *
Join a team that's dedicated to transforming data into actionable insights. As a Senior Analyst, you'll tackle complex challenges, support strategic initiatives, and collaborate with experts to enhanc...
Today
Regional Sales Manager (Healthcare) - St.Louis / Kansas City / OKC
$100K - $120K *
Lead a dynamic sales team to drive growth and profitability in your territory. Develop strategic sales plans, enhance customer retention, and optimize performance through effective collaboration and i...
3 weeks ago
Enterprise Risk Management Data Analytics Lead
$156K - $181K *
Unlock potential by driving enterprise risk management through advanced analytics and reporting solutions. Collaborate with stakeholders to enhance decision-making and operational effectiveness while...
Yesterday
Project Manager III - Clinical Enablement
$87K - $157K *
Champion project success by managing complex initiatives, leading cross-functional teams, and ensuring alignment with strategic objectives through effective planning, execution, and communication...
Today
Senior Regulatory Affairs Associate - Regulatory Intelligence
$95K - $115K *
Drive regulatory intelligence initiatives to ensure compliance and support clinical research. Collaborate with experts to assess regulatory changes, track global guidelines, and enhance impact assessm...
1 week ago
Director Continuous Improvement
$120K - $150K *
Champion continuous improvement initiatives by optimizing processes and products across the organization. Lead cross-functional teams to enhance operational efficiency, quality, and customer experienc...
3 weeks ago
Care Manager RN - UM (Full-Time) Weekends (Remote)
$68K - $105K *
Advance healthcare quality by implementing utilization management strategies. Analyze data for provider enhancement and member satisfaction, while promoting efficient care delivery through collaborati...
Reposted 2 weeks ago
Director, Sales Strategy & Value
$150K - $180K *
Unlock potential by driving sales strategy and value analysis, partnering with cross-functional teams to enhance proposals, pricing, and contracts. Lead market research and client engagement to optimi...
3 weeks ago
Lab Point of Care Sales Specialist
$100K - $115K *
Unlock potential by providing vital sales support and presentations, driving customer integration and product utilization, while conducting market research to enhance offerings. Collaborate closely wi...
Reposted 2 weeks ago
Senior Director Enterprise Services - North Carolina
$159K - $218K *
Drive strategic growth by leading national accounts and fostering executive relationships. Collaborate across teams to enhance customer engagement and market share, while executing comprehensive accou...
3 weeks ago
$73K - $135K *
Analyze and support global sourcing strategies, supplier performance, and data analytics to enhance procurement visibility and decision-making. Manage multiple projects while driving savings and mitig...
Yesterday
Software Product Management Pre Sales Assoc. Director - Health & Human Services Software
$163K - $369K *
Shape the future of enterprise software sales by leading pre-sales engagements, defining solutions, and enabling teams to close high-value deals. Collaborate with clients and partners to deliver impac...
Yesterday
Senior Dynamics Systems Analyst
$100K - $120K *
Join a dynamic team to lead a global transition to D365 F&O, enhancing finance operations through process improvements and automation. Collaborate across departments to streamline complex business pro...
Reposted 6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.