Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$119K - $145K *

Advance supply chain efficiency by optimizing operations, collaborating cross-functionally, and implementing innovative solutions. Engage with stakeholders to analyze performance metrics and support k...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $192K *

Join a team that's poised to lead integrated IT audits while managing client relationships and project execution. Contribute to growth initiatives, talent development, and business solutions for Risk...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$250K - $325K *

Unlock the potential of age-friendly health systems by providing strategic clinical leadership and guidance. Collaborate with health systems to implement the 4Ms framework, driving improvements in car...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Empower enterprise growth by collaborating with Sales Leadership to optimize strategies, manage performance, and enhance sales processes. Drive data-driven decisions and build scalable systems that el...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$100K - $130K *

Unlock your potential as a Senior Financial Analyst, driving financial insights and models to support growth. Collaborate across teams to enhance forecasting accuracy and optimize performance, playing...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$94K - $126K *

Shape the future of cybersecurity by implementing robust security measures, managing risk, and collaborating across teams to protect critical infrastructure and ensure compliance with industry standar...

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$80K - $95K *

Champion a multidisciplinary team to enhance residential treatment services, ensuring compliance and operational excellence while fostering a trauma-informed environment for children and families...

5 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$89K - $105K *

Deliver compelling marketing and policy content that enhances brand voice and reputation. Collaborate with teams to translate complex topics into clear narratives, ensuring high-quality, timely materi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$201K - $251K *

Transform workforce intelligence by leading People Analytics, establishing data governance, and driving strategic decision-making in a high-growth environment. Collaborate across functions to enhance...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion AI deployment by designing and implementing innovative solutions across multiple platforms. Collaborate with teams to enhance customer experiences while ensuring data governance and security...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $200K *

Shape the future of anesthesia care in a collaborative environment, focusing on diverse cases with a supportive team. Enjoy a balanced call rotation and the freedom to lead innovative programs while p...

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock strategic insights by analyzing global and local economic trends to drive decision-making across teams. Collaborate with business development and finance to identify growth opportunities and ma...

2 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$90K - $110K *

Partner with us to deliver high-quality primary care in a supportive, physician-led environment. Engage with patients and clinical staff, focusing on geriatric care while enjoying a collaborative and...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $100K *

Unlock potential by driving treasury processes and cash forecasting for a multi-site organization. Collaborate with finance leadership to enhance liquidity management and support lender reporting, ens...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$125K - $185K *

Elevate health outcomes by collaborating on innovative R&D initiatives, supporting program development, and integrating advanced biological systems with cutting-edge technologies in a dynamic, remote...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$124K - $186K *

Lead the implementation of innovative clinical data solutions to enhance trial efficiency and quality. Collaborate with cross-functional teams to optimize data usage and drive continuous improvement i...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$88K - $105K *

Join a team that's driving digital transformation by coordinating virtual health initiatives, optimizing processes, and enhancing project delivery to improve customer experience and outcomes across th...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K - $150K *

Lead the charge in delivering complex integrations for clients, embedding with their teams to build reusable assets against our API. Transform vague requests into actionable plans while enhancing depl...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$64K - $162K *

Drive innovative strategies to enhance visibility across Generative Engine Optimization and AI search platforms, supporting higher education clients and professional education products through data-dr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$110K - $166K *

Lead the clinical data management process, ensuring quality and compliance from study startup to database lock. Collaborate with teams to develop databases, oversee data integrity, and train personnel...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$74K - $99K *

Engage with cross-functional teams to deliver enterprise APIs, ensuring seamless integration and support for mission-critical applications. Collaborate with partners to translate business needs into t...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock new business opportunities and expand existing client relationships by leveraging your expertise in enterprise sales. Collaborate with teams to deliver tailored solutions and drive growth in a...

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$112K - $192K *

Join a dynamic team to develop and refine cost estimates for critical federal programs, ensuring effective budgetary decisions and enhancing national security through advanced technology solutions...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.