Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Senior Business Analyst, Supply Chain (Oracle Cloud SCM)
$119K - $145K *
Advance supply chain efficiency by optimizing operations, collaborating cross-functionally, and implementing innovative solutions. Engage with stakeholders to analyze performance metrics and support k...
Reposted 1 week ago
Information Technology Auditor (Insurance)
$95K - $192K *
Join a team that's poised to lead integrated IT audits while managing client relationships and project execution. Contribute to growth initiatives, talent development, and business solutions for Risk...
Reposted 2 weeks ago
Senior Clinical Advisor, Age-Friendly Health Systems
$250K - $325K *
Unlock the potential of age-friendly health systems by providing strategic clinical leadership and guidance. Collaborate with health systems to implement the 4Ms framework, driving improvements in car...
2 weeks ago
Physician (Diagnostic Radiologist)
$210K - $250K *
Empower patient care through expert image interpretation and guidance in diagnostic radiology. Collaborate on quality assurance, oversee technical standards, and educate staff while ensuring optimal p...
1 week ago
Sales Strategy & Operations, Enterprise
$120K - $145K *
Empower enterprise growth by collaborating with Sales Leadership to optimize strategies, manage performance, and enhance sales processes. Drive data-driven decisions and build scalable systems that el...
Yesterday
$100K - $130K *
Unlock your potential as a Senior Financial Analyst, driving financial insights and models to support growth. Collaborate across teams to enhance forecasting accuracy and optimize performance, playing...
4 weeks ago
$94K - $126K *
Shape the future of cybersecurity by implementing robust security measures, managing risk, and collaborating across teams to protect critical infrastructure and ensure compliance with industry standar...
2 weeks ago
Executive Director of Residential Treatment
$80K - $95K *
Champion a multidisciplinary team to enhance residential treatment services, ensuring compliance and operational excellence while fostering a trauma-informed environment for children and families...
5 days ago
Writer, Marketing and Communications
$89K - $105K *
Deliver compelling marketing and policy content that enhances brand voice and reputation. Collaborate with teams to translate complex topics into clear narratives, ensuring high-quality, timely materi...
1 week ago
$201K - $251K *
Transform workforce intelligence by leading People Analytics, establishing data governance, and driving strategic decision-making in a high-growth environment. Collaborate across functions to enhance...
3 weeks ago
$110K - $130K *
Champion AI deployment by designing and implementing innovative solutions across multiple platforms. Collaborate with teams to enhance customer experiences while ensuring data governance and security...
3 weeks ago
$150K - $180K *
Empower medical initiatives by leading project teams, providing strategic guidance, and ensuring compliance with regulatory standards while fostering high-performing teams in a dynamic environment...
1 week ago
MISSOURI BAPTIST SULLIVAN HOSPITAL - ANES - STAFF CRNA
$170K - $200K *
Shape the future of anesthesia care in a collaborative environment, focusing on diverse cases with a supportive team. Enjoy a balanced call rotation and the freedom to lead innovative programs while p...
Yesterday
Senior Economic Analyst - Corporate Marketing - Market Insights (Kansas City)
$110K - $130K *
Unlock strategic insights by analyzing global and local economic trends to drive decision-making across teams. Collaborate with business development and finance to identify growth opportunities and ma...
2 weeks ago
Nurse Practitioner or Physician Assistant - Richmond Heights/Clayton - Full Time!
$90K - $110K *
Partner with us to deliver high-quality primary care in a supportive, physician-led environment. Engage with patients and clinical staff, focusing on geriatric care while enjoying a collaborative and...
3 weeks ago
$90K - $100K *
Unlock potential by driving treasury processes and cash forecasting for a multi-site organization. Collaborate with finance leadership to enhance liquidity management and support lender reporting, ens...
Yesterday
ARPA-H Senior Scientist / Engineer (Regenerative Medicine & Advanced Biological Systems)
$125K - $185K *
Elevate health outcomes by collaborating on innovative R&D initiatives, supporting program development, and integrating advanced biological systems with cutting-edge technologies in a dynamic, remote...
Today
Manager, Clinical Data Innovation
$124K - $186K *
Lead the implementation of innovative clinical data solutions to enhance trial efficiency and quality. Collaborate with cross-functional teams to optimize data usage and drive continuous improvement i...
Yesterday
$88K - $105K *
Join a team that's driving digital transformation by coordinating virtual health initiatives, optimizing processes, and enhancing project delivery to improve customer experience and outcomes across th...
2 days ago
$120K - $150K *
Lead the charge in delivering complex integrations for clients, embedding with their teams to build reusable assets against our API. Transform vague requests into actionable plans while enhancing depl...
4 weeks ago
Senior Manager, GEO Strategy & AI Search Activation
$64K - $162K *
Drive innovative strategies to enhance visibility across Generative Engine Optimization and AI search platforms, supporting higher education clients and professional education products through data-dr...
3 weeks ago
$110K - $166K *
Lead the clinical data management process, ensuring quality and compliance from study startup to database lock. Collaborate with teams to develop databases, oversee data integrity, and train personnel...
Today
API IT Solutions Analyst II - Remote
$74K - $99K *
Engage with cross-functional teams to deliver enterprise APIs, ensuring seamless integration and support for mission-critical applications. Collaborate with partners to translate business needs into t...
1 week ago
$110K - $130K *
Unlock new business opportunities and expand existing client relationships by leveraging your expertise in enterprise sales. Collaborate with teams to deliver tailored solutions and drive growth in a...
2 weeks ago
$112K - $192K *
Join a dynamic team to develop and refine cost estimates for critical federal programs, ensuring effective budgetary decisions and enhancing national security through advanced technology solutions...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.