Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Clinical Documentation Manager
$111K *
Unlock potential by leading Clinical Documentation Integrity operations, enhancing physician engagement, and driving performance improvement. Collaborate with diverse teams to ensure compliance and op...
4 weeks ago
$71K - $100K *
Drive strategic initiatives by analyzing market trends and performance metrics. Collaborate with cross-functional teams to develop business cases and forecasts, ensuring data integrity and delivering...
2 weeks ago
$120K - $145K *
Join a team that's dedicated to safeguarding sensitive health information while enhancing security across cloud and application environments. As a Senior Security Engineer, you'll design and implement...
5 days ago
Director, Software Engineering, Healthcare Interoperability
$180K - $215K *
Lead a dynamic team to innovate and enhance healthcare technology solutions. Drive cross-functional collaboration, mentor engineers, and ensure high-quality software delivery while aligning with strat...
Today
Healthcare IT Workstream Project Manager
$90K - $105K *
Drive the migration of patient data within a healthcare IT modernization program. Oversee planning, execution, and reporting for your workstream, ensuring alignment with stakeholders and delivery of h...
6 days ago
Advanced Practice Provider (NP or PA): Palliative Care
$120K - $155K *
Empower patients by delivering compassionate, patient-centered palliative care through virtual consultations. Collaborate with a dynamic team to enhance quality of life for members with complex needs...
3 weeks ago
$83K - $222K *
Transform data engineering practices by designing robust data pipelines and models. Collaborate with cross-functional teams to enhance analytics capabilities and ensure data quality, governance, and p...
5 days ago
$113K - $197K *
Lead regulatory and compliance oversight for Operations, ensuring accuracy and efficiency. Collaborate with enterprise partners to enhance operational processes, implement automation, and drive contin...
1 week ago
Lead Analyst - Independent Assessment
$98K - $115K *
Lead independent assessments to evaluate and enhance the Bank's risk management practices, ensuring compliance with evolving regulatory standards while guiding a team of analysts in a dynamic environm...
5 days ago
$80K - $95K *
Take ownership of revenue modeling and forecasting, leveraging AI to automate processes and enhance reporting accuracy. Collaborate across functions to drive financial insights and support strategic d...
Today
Information Protection Advisor - SSP & CMMC Programs
$103K - $171K *
Elevate security compliance by collaborating with cross-functional teams to maintain accurate documentation and support federal compliance initiatives, ensuring systems meet evolving cybersecurity sta...
3 weeks ago
Senior Director, Actuarial Services
$235K - $270K *
Unlock potential by leading actuarial strategy and health economic analyses. Collaborate with cross-functional teams to enhance value propositions and drive commercial growth while translating complex...
Today
Senior Applications Security Engineer, AI & Automation Development
$87K - $161K *
Optimize automation and AI capabilities within Security Defense Technologies. Collaborate with teams to design AI solutions, enhance Kubernetes operations, and implement secure development practices t...
Today
Internal Business Systems Consultant
$86K - $138K *
Empower your career by leading business analysis efforts, collaborating with stakeholders to enhance system applications, and driving innovative solutions that improve operational efficiency and user...
Today
$125K - $150K *
Pioneer in radiology innovation by enhancing clinical value and technology. Join a forward-thinking team that prioritizes high-quality patient care while driving improvements in service and operationa...
Reposted 3 weeks ago
$101K - $145K *
Lead the charge in leveraging advanced data science techniques to solve complex business challenges, mentor junior team members, and drive effective risk management through innovative algorithms and d...
2 weeks ago
$80K - $95K *
Drive analytical excellence by auditing freight contracts and invoices, ensuring compliance and accuracy. Collaborate with teams to enhance audit processes and mentor junior analysts, contributing to...
1 week ago
Managing Consultant - Revenue Integrity - Healthcare
$120K - $165K *
Join a dynamic team as a Managing Consultant, driving innovative solutions in Revenue Integrity. Oversee engagements, enhance client relationships, and lead project teams to optimize financial perform...
2 weeks ago
$69K - $101K *
Lead the charge in holistic clinical care management, enhancing health outcomes through comprehensive assessments, care planning, and coordination for diverse member populations with complex needs...
3 weeks ago
$90K - $105K *
Unlock potential by supporting compensation programs through analysis, reporting, and administration. Collaborate with HR and finance teams to ensure accurate employee compensation data and streamline...
1 week ago
$110K - $130K *
Transform financial operations by leveraging Workday expertise to enhance reporting, payroll, and planning processes. Collaborate with cross-functional teams to deliver scalable solutions and drive co...
Reposted 3 weeks ago
$78K - $113K *
Innovate healthcare fraud prevention by leading complex investigations, evaluating medical necessity, and collaborating with regulatory agencies to ensure quality member care and safeguard plan assets...
5 days ago
$78K - $113K *
Unlock potential by leading complex investigations into healthcare fraud, waste, and abuse. Collaborate with regulatory agencies and internal teams to ensure compliance and safeguard member care while...
5 days ago
Senior Director Analyst - Digital Workplace - Enterprise Application Architecture and Operations
$172K - $202K *
Innovate within identity and access management by providing expert insights and strategies to clients on best practices in identity governance, privileged access, and AI tools, enhancing cybersecurity...
Reposted 3 weeks ago
Regional Sales Manager, Healthcare
$80K - $95K *
Transform your career by driving sales growth in a dynamic healthcare market. Leverage your consultative selling skills to build relationships, develop new business, and enhance client engagement in a...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.