Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$90K - $110K *

Join a team that's dedicated to enhancing HR data integration. Leverage your Workday expertise to design, implement, and maintain seamless connections between systems, ensuring data integrity and perf...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Strategize and lead complex technical analysis to bridge business needs with IT solutions, ensuring compliance and efficiency across enterprise operations while mentoring teams and driving continuous...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$68K - $100K *

Lead the charge in optimizing patient admissions and resource utilization. Collaborate with healthcare teams to ensure compliance with payer guidelines while enhancing care delivery and discharge proc...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $116K *

Unlock potential as a mid-level actuarial analyst, applying statistical techniques to enhance insurance pricing, claims analysis, and profitability studies while progressing through the Actuarial Exec...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $237K *

Unlock potential by leading actuarial strategies that drive innovation and performance. Oversee a team, develop statistical models, and engage with regulators to ensure compliance and support business...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$103K - $192K *

Shape the future of healthcare reimbursement by leading analytics for payor contracting and out-of-network strategies. Collaborate with cross-functional teams to optimize financial outcomes and drive...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$68K - $105K *

Transform your career by configuring and supporting Epic applications. Engage in systems analysis, design, and problem resolution while collaborating with end-users to enhance their experience and str...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$90K - $110K *

Take ownership of public health initiatives by analyzing data, managing projects, and ensuring compliance. Collaborate with stakeholders to enhance health outcomes for affected populations through eff...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Innovate post-acute payment integrity by developing and optimizing audit concepts for DME, home health, and infusion therapy claims. Collaborate cross-functionally to ensure compliance and enhance ope...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $100K *

Unlock insights by analyzing customer and operational data to enhance business outcomes. Collaborate with cross-functional teams to develop dashboards and reports that drive strategic decisions and im...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$124K - $207K *

Drive impactful analytics in Medical Affairs by developing KPIs, analyzing data trends, and collaborating with cross-functional teams to enhance decision-making and resource allocation for optimal bus...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$72K - $115K *

Partner with us to design and validate predictive models that enhance business processes across various domains, leveraging data science techniques to drive insights and improve decision-making within...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $110K *

Analyze coding quality data and support compliance initiatives to enhance hospital coding accuracy. Collaborate with teams to develop guidance and conduct audits, ensuring adherence to regulatory stan...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$79K - $105K *

Develop and implement strategies to manage financial and compliance risks in a dynamic payments environment. Analyze transaction patterns to identify risks and collaborate with teams to enhance fraud...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$113K - $188K *

Optimize security administration and reporting processes while collaborating with cross-functional teams to enhance data insights and compliance metrics. Drive effective use of Workday tools and ensur...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$90K - $115K *

Partner with us to enhance client engagement and product success by leveraging your analytical skills and industry insights. Collaborate cross-functionally to drive improvements and support user adopt...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$98K - $163K *

Analyze and maintain program data to enhance recruitment and onboarding processes. Collaborate with stakeholders to ensure accurate reporting and insights that drive decision-making and improve partic...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Drive the design, build, testing, and support of applications, ensuring optimal functionality and user satisfaction while collaborating with interdisciplinary teams to enhance workflows and resolve co...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Analyze and manage healthcare data, optimizing pipelines and reporting. Collaborate with stakeholders to turn data into actionable insights. Embrace growth in a dynamic environment, taking ownership o...

Earth City, MORemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$89K - $133K *

Empower success by leading healthcare technology implementations, optimizing workflows, and ensuring compliance. Collaborate across teams to guarantee smooth integrations and enhance system functional...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$111K - $168K *

Drive sales success by engaging clients, leading teams, and delivering tailored Identity Security solutions. Collaborate with partners to exceed revenue goals while ensuring exceptional customer exper...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$115K - $143K *

Unlock the potential of data by architecting scalable pipelines and driving analytics initiatives, mentoring engineers, and collaborating with cross-functional teams to enhance our data solutions in a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$87K - $230K *

Shape the future of healthcare technology by managing complex programs, leading cross-functional teams, and driving measurable outcomes for clients. Collaborate with stakeholders to ensure high-qualit...

1 week ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.