Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$150K - $180K *
Lead Corporate FP&A initiatives, driving budgeting, forecasting, and performance management. Oversee financial analysis and reporting while enhancing systems and dashboards for improved decision-makin...
3 weeks ago
Manager Population Health Care Management - Registered Nurse
$80K - $95K *
Manage and enhance care management operations, ensuring effective implementation of evidence-based practices while fostering team collaboration and patient satisfaction across diverse healthcare setti...
3 days ago
VP OF SALES - EAST COAST - HEALTHCARE
$160K - $200K *
Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...
Reposted 1 week ago
Senior Manager, Actuarial AI & Enterprise Performance
$157K - $205K *
Elevate your career by leading strategic operations within Medicare Advantage, leveraging analytics and AI to drive performance, align cross-functional initiatives, and provide actionable insights tha...
Reposted today
Remote Medical Director, Inpatient Medicare
$215K - $408K *
Explore innovative medical management strategies while leading quality improvement initiatives and collaborating with clinical teams to enhance patient care and operational efficiency...
Today
$90K - $110K *
Advance your career by delivering critical cost estimates for federal programs. Collaborate with a dynamic team to enhance national security through effective budgeting and analysis of advanced commun...
1 week ago
$127K - $224K *
Drive impactful product modeling and marketing measurement as a Staff Data Scientist. Own the lifecycle of ML models, collaborate with PMs, and communicate insights effectively to enhance user experie...
Today
Senior Manager, State and Local Government Relations (Western US)
$150K - $268K *
Drive state and local government relations across 25 states, managing legislative efforts and stakeholder engagement to advance business goals. Collaborate with internal teams and external partners to...
2 weeks ago
$190K - $305K *
Join a team that's shaping healthcare by providing legal guidance on regulatory matters, employee benefits, and AI initiatives. As a senior contributor, you'll lead complex reviews, manage risks, and...
Today
Lead Consultant CDH Implementation
$105K - $149K *
Transform complex Consumer-Directed Health implementations for major employers. Lead strategy, execution, and client engagement while serving as a subject-matter expert to ensure operational excellenc...
1 week ago
VP, Sales - Health Services and Technology
$180K - $220K *
Engage with healthcare services and technology leaders to drive new business growth. Leverage a robust support system to build relationships, execute territory plans, and expand existing accounts whil...
2 weeks ago
Senior Compliance Analyst (Compliance Oversight Activities) - Remote
$74K - $118K *
Elevate compliance standards by leading oversight initiatives, managing complex projects, and collaborating across teams to ensure regulatory adherence and effective governance in a dynamic environmen...
1 week ago
$80K - $95K *
Lead the integration of departmental services, ensuring quality care and compliance. Develop policies, train staff, and enhance performance while collaborating across departments to meet patient and o...
4 weeks ago
$104K - $166K *
Join a team that's dedicated to enhancing cybersecurity operations. As a Senior SOC Analyst, you'll monitor threats, analyze network traffic, and lead incident response efforts while mentoring junior...
1 week ago
$70K - $180K *
Drive impactful healthcare technology solutions through data-driven strategies, optimize customer engagements with compelling insights, and foster long-term partnerships for strategic growth...
Reposted 1 week ago
Business Analyst - MDM & Data Governance
$95K - $115K *
Unlock potential by bridging business and technical teams to define and implement master data management and governance solutions, ensuring data quality and compliance across the organization...
4 weeks ago
Senior Quality Operations Specialist, CAP & Monitoring
$74K - $98K *
Elevate quality operations by leading corrective action plans (CAPs) for regulatory compliance. Collaborate with cross-functional teams to drive accountability, resolve barriers, and ensure sustained...
4 weeks ago
Clinical Performance Advisor - RN
$80K - $100K *
Unlock potential by leading clinical performance initiatives and enhancing patient care. Collaborate with healthcare teams to improve quality, manage operations, and support staff development in a dyn...
3 weeks ago
$93K - $167K *
Reimagine mental health care as a Psychologist Reviewer, ensuring appropriate utilization of services and clinical guidelines while collaborating with Behavioral Health providers and enhancing care ma...
Reposted 2 weeks ago
Commercial Real Estate Underwriting Analyst
$78K - $110K *
Contribute to high-quality pre and post-closing services in real estate underwriting. Collaborate with teams to analyze market data, assist in credit presentations, and ensure compliance with loan ter...
4 days ago
Director, Enterprise Enablement
$150K - $180K *
Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...
Reposted 1 week ago
Interventional Clinical Consultant-East
$110K - $130K *
Serve as a clinical and technical leader, influencing decision-makers and supporting product innovation in interventional healthcare. Engage with key stakeholders and showcase advanced solutions to en...
6 days ago
$77K - $115K *
Join a team that's driving innovation in IT solutions by leveraging your expertise in systems analysis and functional design. Collaborate with cross-functional teams to enhance business processes and...
3 weeks ago
Account Manager- Client Success
$80K - $85K *
Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...
1 week ago
$120K - $140K *
Accelerate progress at the forefront of specialty care, delivering impactful Pulmonology services. Collaborate with interdisciplinary teams to provide high-quality, patient-centered care in skilled nu...
Reposted 3 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.