Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Business Development Director I, Early Drug Development
$80K - $120K *
Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...
Reposted 1 week ago
$110K - $130K *
Join us to lead the development and execution of clinical study designs, ensuring effective project management and collaboration across teams. Your expertise will drive the success of clinical trials...
2 weeks ago
$99K - $164K *
Join a team that's dedicated to enhancing client relationships through strategic management and satisfaction. You'll oversee client communications, identify growth opportunities, and ensure service ex...
Today
$110K - $130K *
Unlock potential by leading cross-functional initiatives to enhance caregiver enrollment technology. Drive strategy, optimize user experiences, and leverage data analytics to achieve growth in a dynam...
Yesterday
$150K - $180K *
Pioneer innovative strategies as a Medical Science Liaison, engaging with key opinion leaders and driving platform adoption. Collaborate across teams to translate clinical needs into actionable insigh...
2 weeks ago
$80K - $95K *
Lead advanced troubleshooting and repair of medical equipment, ensuring customer satisfaction through service excellence. Collaborate with teams, mentor junior engineers, and drive initiatives to enha...
2 weeks ago
$72K - $100K *
Join our dynamic team as a Sr. Credit Analyst, owning the underwriting cycle from application review to decision-making. Leverage your analytical skills to enhance credit processes and contribute to a...
2 weeks ago
Google Cloud & Gemini Enterprise Administrator
$110K - $130K *
Champion the administration of Google Cloud and Gemini Enterprise environments, ensuring secure, scalable configurations. Collaborate with IT and business teams to optimize cloud services and support...
3 weeks ago
Field Clinical Applications Specialist
$90K - $110K *
Elevate your career by providing expert support in molecular diagnostics, driving product implementation, and fostering strong relationships with clinical laboratories to ensure successful adoption an...
2 weeks ago
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
Senior Advisor, Clinical Pharmacology
$153K - $268K *
Join our team to provide expert clinical pharmacology insights, driving dose selection and study design for innovative therapies. Collaborate with cross-functional teams to translate complex data into...
1 week ago
Manager Regulatory Intelligence
$120K - $180K *
Shape the future of regulatory intelligence by leading cross-functional teams, managing global surveillance workstreams, and translating complex regulations into actionable insights for stakeholders a...
1 week ago
Regional Sales Director - Richmond
$180K - $215K *
Lead the charge in driving regional sales success through strategic execution, team leadership, and cross-functional collaboration. Foster strong customer relationships and ensure alignment with corpo...
1 week ago
Payment Integrity Program Manager
$73K - $120K *
Drive the success of inpatient Payment Integrity programs by overseeing audits, ensuring compliance, and enhancing quality across teams and vendors. Collaborate with stakeholders to optimize processes...
3 weeks ago
Head of Clinical Quality and Regulatory
$208K - $220K *
Drive enterprise leadership in clinical quality and regulatory readiness, ensuring consistent standards and governance across regions. Collaborate with stakeholders to translate quality insights into...
1 week ago
$170K - $200K *
Empower a high-growth organization by leading operations strategy, enhancing client satisfaction, and driving efficiency through AI and automation. Collaborate with senior leadership to ensure financi...
2 days ago
Senior Oncology Account Manager, Cincinnati
$150K - $230K *
Transform your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative s...
1 week ago
Vice President, Revenue Integrity - DRG & DRGV (REMOTE)
$150K - $180K *
Drive your career with a leadership role focused on Revenue Integrity, overseeing strategic direction, performance metrics, and team development to enhance operational efficiency and client satisfacti...
2 days ago
$150K - $180K *
Transform clinical research practices by guiding study design and analysis. Collaborate with cross-functional teams to deliver key insights and evidence that drive product innovation in the healthcare...
Reposted 5 days ago
Director, Project Management; Healthcare RCM Transformation
$120K - $140K *
Drive your career forward by leading a dynamic PMO team, overseeing complex projects in healthcare technology. Collaborate cross-functionally to ensure strategic alignment and successful execution of...
2 weeks ago
DRG Quality Analyst IV - Healthcare
$85K - $110K *
Optimize clinical DRG audits by ensuring accuracy and consistency in coding. Mentor auditors, recommend process improvements, and conduct quality reviews to enhance performance and compliance in a rem...
1 week ago
$250K - $286K *
Shape the future of sales by leading a dynamic team to drive new business, refine strategies, and enhance customer experiences in a fast-paced SaaS environment, while mentoring leaders and achieving a...
3 weeks ago
Director, Copay & Affordability
$199K - $269K *
Shape patient affordability strategies by leading a dynamic team focused on co-pay programs and innovative solutions. Collaborate cross-functionally to enhance operations, optimize performance, and dr...
Reposted 3 days ago
Associate/Sr. Associate, Academic Partnering, Asset Acquisition
$130K - $150K *
Advance innovative therapeutic programs targeting genetically driven diseases through strategic sourcing, relationship building, and cross-functional collaboration, ensuring a patient-first approach i...
Yesterday
$200K - $232K *
Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.