Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Epic Application Analyst - ClinDoc/Stork
$80K - $95K *
Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...
1 week ago
Cardiovascular Account Specialist - U.S. Sales, Philadelphia East, PA
$162K - $195K *
Shape the future of cardiovascular care by driving the launch of a novel cardiac myosin inhibitor. Collaborate with healthcare professionals and internal teams to establish strategic relationships and...
Yesterday
Director of Active Ingredient Supply (GCS)
$125K - $150K *
Transform supply chain operations by leading procurement, inventory management, and cash planning. Collaborate with cross-functional teams to ensure product delivery, regulatory compliance, and contin...
Yesterday
$80K *
Empower clients by managing complex care needs through remote case management, ensuring access to high-quality treatment and support. Collaborate with multidisciplinary teams to enhance client engagem...
2 weeks ago
Physical Therapist Home Health
$80K - $95K *
Elevate patient care by developing tailored rehabilitation plans, performing evaluations, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcomes and ensure...
2 weeks ago
Sr. Director, Regional Sales, Central - Intismeran
$196K - $353K *
Empower your career by leading a dynamic oncology sales team to drive regional strategy and execution. Collaborate with partners to launch innovative therapies, build key relationships, and shape the...
1 week ago
Director, Neurology - Thought Leader Liaison (Central)
$245K - $265K *
Optimize partnerships with Medical Experts to enhance neurology care. Drive strategic insights and educational initiatives while collaborating across teams to influence business decisions and improve...
2 weeks ago
$150K - $180K *
Shape the future of AI evaluation by leading rigorous methodologies, collaborating with engineers, and mentoring teams to ensure accurate assessments that drive product innovation and market standards...
3 days ago
Senior Compliance Program Manager, GRC
$120K - $140K *
Drive compliance excellence as a Senior Compliance Program Manager, overseeing complex initiatives across enterprise and federal environments. Collaborate with cross-functional teams to ensure audit r...
2 weeks ago
$120K - $140K *
Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...
2 weeks ago
$72K - $107K *
Join a team that's dedicated to enhancing resident development through effective program management, collaboration with clinical leaders, and innovative professional development sessions to ensure a s...
Today
Managing Consultant - Coding and Middle Revenue Cycle - Healthcare
$120K - $165K *
Lead transformative consulting engagements to enhance healthcare coding and middle revenue cycle processes, driving operational efficiency, compliance, and financial performance across diverse project...
1 month ago
VP, Payer Sales - National Accounts
$160K - $172K *
Elevate your career by driving growth in national health plan accounts. Leverage your expertise to build relationships, negotiate complex deals, and exceed revenue targets while collaborating with cro...
2 weeks ago
Optometrist - Doctor of Optometry (Employee)
$150K - $200K *
Join a dynamic team to conduct comprehensive eye exams and diagnose ocular conditions using innovative technology. Educate patients on eye care and develop personalized treatment plans in a hybrid wor...
1 week ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Empower patients by delivering exceptional eye care solutions. Conduct comprehensive exams, diagnose conditions, and create personalized treatment plans in a dynamic, patient-centered environment that...
1 week ago
Optometrist - Doctor of Optometry (Employee)
$200K *
Join a team that's dedicated to delivering exceptional eye care solutions while thriving in a dynamic, patient-centered environment. Utilize innovative technology to conduct comprehensive exams and cr...
1 week ago
$165K - $215K *
Shape the future of value-based payments by leading product strategy, overseeing team development, and driving market innovations within a collaborative, cross-functional environment...
4 weeks ago
Head of National Strategic Accounts
$250K - $300K *
Champion strategic growth by leading the charge to secure complex health system accounts. Drive transformative deals with hands-on coaching, leveraging deep relationships and expertise to elevate team...
Reposted 2 weeks ago
Senior Accountant, Primary Care
$78K - $107K *
Drive financial integrity by managing complex accounting tasks, preparing reports, and influencing departmental strategy. Collaborate with teams to ensure compliance and accuracy while providing valua...
Reposted today
Senior Director Payer Contracting
$150K - $180K *
Join us to lead payer contracting strategies, negotiate complex agreements, and enhance reimbursement performance across diverse healthcare models while managing a high-performing team in a dynamic, r...
3 weeks ago
$125K - $170K *
Lead the charge in managing complex contracts for a major program, ensuring compliance and strategic alignment. Collaborate with teams to develop proposals, negotiate terms, and maintain strong relati...
1 week ago
Third-Party Security Risk Analyst
$58K - $110K *
Take ownership of third-party risk management by assessing vendors, documenting risks, and ensuring compliance. Collaborate with cross-functional teams to enhance security measures and support audits...
Yesterday
$110K - $130K *
Manage and lead field-based medical teams, ensuring client delivery and team performance while fostering scientific engagement and program growth. Collaborate with cross-functional teams to achieve st...
3 weeks ago
Executive Director, Technology
$175K - $215K *
Elevate the technology function by leading engineering, delivery, and operations. Collaborate closely with leadership to shape technical strategy, ship code weekly, and ensure high standards in a dyna...
2 weeks ago
Business Development Director I, Early Drug Development
$80K - $120K *
Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.