Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Executive Medical Director (Retina Program)
$350K - $398K *
Drive impactful clinical trials in ophthalmology with leadership in study design, execution, and biomarker strategy. Collaborate cross-functionally to ensure timely delivery and regulatory compliance...
Reposted 3 weeks ago
$102K - $120K *
Join a team that's transforming healthcare analytics by bridging complex data with strategic insights. Leverage your SQL expertise and analytics engineering skills to empower stakeholders and drive va...
4 weeks ago
Director, Cost of Care Solutions
$129K - $162K *
Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...
Reposted 1 week ago
$96K - $144K *
Lead the charge in delivering exceptional customer service and technical support at assigned medical equipment sites, ensuring compliance with contracts and fostering strong client relationships throu...
2 weeks ago
$84K - $126K *
Empower decision-making by transforming data into intuitive models. Collaborate with stakeholders to ensure metrics are clear and trusted, while optimizing data for analytics and reporting across the...
Yesterday
Head of Customer Success, Payer & Employer
$137K - $205K *
Transform customer relationships by leading a team to enhance account management, drive product adoption, and ensure client success in the healthcare sector, fostering growth and retention across dive...
3 weeks ago
$110K - $130K *
Elevate your career by leading strategic IT solutions and driving software asset management excellence. Collaborate with stakeholders, mentor peers, and influence outcomes through innovative analysis...
1 week ago
Vice President Enterprise Sales - Florida
$205K - $380K *
Engage as a strategic leader in enterprise sales, driving growth by securing key healthcare partnerships and executing market strategies. Collaborate with cross-functional teams to enhance customer va...
4 weeks ago
Senior Consultant - Regulatory
$110K - $130K *
Shape client success by leading complex consulting projects, integrating diverse workstreams into actionable insights, and driving high-quality deliverables while fostering team growth and managing st...
Reposted 3 days ago
$100K - $122K *
Unlock potential by leading a dynamic accounting team, managing full-cycle accounting processes, ensuring compliance, and driving process improvements in a fast-paced environment. Collaborate with fin...
3 weeks ago
Adult Nutrition Acute Care Specialist - Dallas-Fort Worth
$61K - $122K *
Join a team that's driving impactful sales strategies for leading nutrition brands. You will engage with healthcare professionals and expand market share through clinical insights and strong relations...
Reposted 2 weeks ago
Hematology/Oncology Specialist - Houston TX
$170K - $210K *
Unlock potential by driving strategic initiatives in oncology sales, fostering relationships with key stakeholders, and ensuring patient access to innovative therapies while achieving business goals t...
2 days ago
Director, Regional Marketing Americas
$160K - $180K *
Drive impactful regional marketing strategies that enhance customer engagement and pipeline growth across the Americas. Collaborate with global teams to create tailored campaigns and support sales ini...
Yesterday
$195K - $277K *
Drive innovative clinical oncology studies by designing protocols, collaborating with teams, and ensuring compliance with regulations. Leverage expertise to analyze data, support publications, and mai...
3 weeks ago
$184K - $254K *
Shape the future of corporate strategy by leading cross-functional teams to develop enterprise-wide strategic plans, drive growth initiatives, and influence senior leadership decisions through data-dr...
2 days ago
Senior Consultant, Healthcare Finance (Healthcare & Medicaid Finance and Analysis)
$95K - $130K *
Unlock potential by driving healthcare finance consulting excellence. Collaborate with project teams to enhance service delivery through financial modeling, data analytics, and quality improvement ini...
1 week ago
$127K - $165K *
Unlock potential by leading regulatory strategies for innovative medical devices. Collaborate with teams to ensure compliance, execute FDA submissions, manage project timelines, and establish processe...
Reposted 6 days ago
Healthcare Merchant Payment Solutions Consultant- Mid-Market
$126K - $154K *
Empower healthcare organizations by optimizing payment solutions and driving growth. This remote role involves building executive relationships and addressing complex revenue cycle challenges within m...
1 week ago
Senior Software Engineer, Portal Application
$125K - $157K *
Join our dynamic team to design and enhance a web portal application, improving user experience and functionality. Collaborate with engineers and product managers to deliver impactful solutions that s...
3 days ago
$125K - $160K *
Join a dynamic team as a Sr. Health Benefit Plan Consulting Attorney, leveraging your expertise in healthcare law to navigate complex regulatory issues, support consulting services, and drive complian...
Yesterday
Regional Sales Director - Midwest
$180K - $215K *
Develop and lead regional strategies to drive product launch success, ensuring alignment with corporate goals. Build a high-performing team, foster customer relationships, and execute data-driven deci...
1 week ago
$80K - $95K *
Partner with us to enhance clinical IT solutions as an Epic Analyst II, providing critical support, training, and implementation for Epic EHR systems. Collaborate with teams to optimize workflows and...
2 weeks ago
Sr. Sustainability Engineer - Radiopharmaceutical Manufacturing
$110K - $130K *
Innovate your career with a key role supporting the global launch and technical operations of radiopharmaceuticals, driving compliance, quality initiatives, and collaboration with CDMOs while leading...
Reposted 1 week ago
Group Account Director (Medical Affairs)
$165K - $185K *
Join a team that's shaping strategic direction and driving growth across multi-account projects in medical affairs. In this senior leadership role, you'll enhance client relationships, develop teams...
Reposted 1 week ago
Clinical Sales Specialist, Pulmonary
$110K - $130K *
Unlock your potential by driving sales of innovative pulmonary solutions. Collaborate with diverse stakeholders to enhance patient care and achieve sales targets in a dynamic healthcare environment. J...
Reposted 4 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.